Contribution of renal biopsy data in predicting outcome in lupus nephritis. Analysis of 116 patients.

We reassessed renal biopsy specimens from 116 patients with systemic lupus erythematosus and clinical manifestations of lupus nephritis to determine the contributions of the World Health Organization classification system, the activity and chronicity indexes of the National Institutes of Health scoring system, and various clinical parameters at the time of biopsy to predicting disease outcome. Multivariate analysis showed that only a chronicity index greater than 3 was predictive for decreased renal survival, while age greater than 31 years at biopsy and a chronicity index greater than 3 were associated with decreased patient survival. Clinical tests of renal function were not reliable in discriminating between active lesions and chronic renal damage.

[1]  J. Esdaile,et al.  The relationship of socioeconomic status to subsequent health status in systemic lupus erythematosus. , 1988, Arthritis and rheumatism.

[2]  D. Estes,et al.  THE NATURAL HISTORY OF SYSTEMIC LUPUS ERYTHEMATOSUS BY PROSPECTIVE ANALYSIS , 1971, Medicine.

[3]  Q. Whiting-O'Keefe,et al.  Recognition of information in renal biopsies of patients with lupus nephritis. , 1982, Annals of internal medicine.

[4]  D. Wallace,et al.  Lupus nephritis: Experience with 230 patients in a private practice from 1950 to 1980 , 1982 .

[5]  N. Vaziri,et al.  Chronic hemodialysis in end-stage lupus nephritis: changes of clinical and serological activities. , 1984, Artificial organs.

[6]  K. Lynn,et al.  Lupus nephritis: a 13-year experience. , 1986, The New Zealand medical journal.

[7]  I. Stamenkovic,et al.  Renal biopsy in SLE irrespective of clinical findings: long-term follow-up. , 1986, Clinical nephrology.

[8]  J F Fries,et al.  The 1982 revised criteria for the classification of systemic lupus erythematosus. , 1982, Arthritis and rheumatism.

[9]  D. Oakes Comparison of models for survival data. , 1983, Statistics in medicine.

[10]  J. Klippel,et al.  Prognostic factors in lupus nephritis. Contribution of renal histologic data. , 1983, The American journal of medicine.

[11]  M. Delezé,et al.  Cardiovascular Manifestations in Systemic Lupus Erythematosus. Prospective Study of 100 Patients , 1985, Angiology.

[12]  W. P. Reed,et al.  Host defenses and immunologic alterations associated with chronic hemodialysis. , 1980, Annals of internal medicine.

[13]  J. Fries,et al.  A multicenter study of outcome in systemic lupus erythematosus. I. Entry variables as predictors of prognosis. , 1982, Arthritis and rheumatism.

[14]  J. Balfe,et al.  Correlation of renal histology with outcome in children with lupus nephritis. , 1986, Kidney international.

[15]  A. Steinberg,et al.  Systemic Lupus Erythematosus: Evolving Concepts , 1979 .

[16]  E. Lewis,et al.  The prognosis of segmental glomerulonephritis in systemic lupus erythematosus. , 1987, Kidney international.

[17]  N. Ordóñez,et al.  LUPUS NEPHROPATHY WITHOUT CLINICAL RENAL INVOLVEMENT , 1977, Medicine.

[18]  D. Baldwin,et al.  Lupus nephritis: Clinical course as related to morphologic forms and their transitions , 1977 .

[19]  A. Steinberg,et al.  NIH conference. Lupus nephritis. , 1987, Annals of internal medicine.

[20]  W. Roberts,et al.  The heart in systemic lupus erythematosus and the changes induced in it by corticosteroid therapy: A study of 36 necropsy patients , 1975 .

[21]  M. Liang,et al.  Marginal benefit of renal biopsy in systemic lupus erythematosus. , 1978, Archives of internal medicine.