Simultaneous estimation of attenuation and structure parameters of aggregated red blood cells from backscatter measurements.

The analysis of the ultrasonic frequency-dependent backscatter coefficient of aggregating red blood cells reveals information about blood structural properties. The difficulty in applying this technique in vivo is due to the frequency-dependent attenuation caused by intervening tissue layers that distorts the spectral content of backscattering properties from blood microstructures. An optimization method is proposed to simultaneously estimate tissue attenuation and blood structure factor. With in vitro experiments, the method gave satisfactory estimates with relative errors below 22% for attenuations between 0.101 and 0.317 dBcmMHz, signal-to-noise ratios>28 dB and kR<2.7 (k being the wave number and R the aggregate radius).

[1]  R. L. Romijn,et al.  Ultrasound attenuation and texture analysis of diffuse liver disease: methods and preliminary results. , 1991, Physics in medicine and biology.

[2]  Timothy A Bigelow,et al.  Estimation of total attenuation and scatterer size from backscattered ultrasound waveforms. , 2005, The Journal of the Acoustical Society of America.

[3]  M A Srinivasan,et al.  High-frequency ultrasonic attenuation and backscatter coefficients of in vivo normal human dermis and subcutaneous fat. , 2001, Ultrasound in medicine & biology.

[4]  R. Kuc,et al.  Estimating the Acoustic Attenuation Coefficient Slope for Liver from Reflected Ultrasound Signals , 1979, IEEE Transactions on Sonics and Ultrasonics.

[5]  G. Berger,et al.  Absolute backscatter coefficient over a wide range of frequencies in a tissue-mimicking phantom containing two populations of scatterers , 1996, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[6]  V. Twersky,et al.  Low-Frequency Scattering by Correlated Distributions of Randomly Oriented Particles , 1987 .

[7]  P He,et al.  Application of stochastic analysis to ultrasonic echoes--estimation of attenuation and tissue heterogeneity from peaks of echo envelope. , 1986, The Journal of the Acoustical Society of America.

[8]  Guy Cloutier,et al.  Experimental ultrasound characterization of red blood cell aggregation using the structure factor size estimator. , 2007, The Journal of the Acoustical Society of America.

[9]  K. Shung,et al.  An approach for measuring ultrasonic backscattering from biological tissues with focused transducers , 1997, IEEE Transactions on Biomedical Engineering.

[10]  G. Cloutier,et al.  P6C-11 In Vitro Study of Frequency-Dependent Blood Echogenicity Under Pulsatile Flow , 2007, 2007 IEEE Ultrasonics Symposium Proceedings.

[11]  K. Shung,et al.  On the Ultrasound Scattering from Blood as a Function of Hematocrit , 1982, IEEE Transactions on Sonics and Ultrasonics.