Streptococcus parasanguinis: An emerging pathogen causing neonatal endocarditis: A case report

Background. The microbial infection of the endocardium, popularly known as Infective Endocarditis (IE), is typically classified on the basis of anatomy, valve nativity and its associated microbiology. As per the associated microbiology, Staphylococcus aureus is the most common microorganism responsible for the cause of IE. Even though, the Streptococcus group accounts for a smaller percentage of IE, however this doesn’t give us the liberty of ignoring the high mortality and morbidity associated with this pathogen. Case presentation. We report an unusual case of neonatal sepsis, complicated with endocarditis, caused by penicillin resistant Streptococcus parasanguinis . The neonate however died of the same despite all efforts. The said baby was given birth by a mother with gestational diabetes mellitus. Conclusion. High index of clinical suspicion and prompt diagnosis are the most important factors of patient management, especially in cases of life threatening neonatal infections. In such conditions a coordinated interdepartmental approach is very much needed.

[1]  M. Hannan,et al.  The 2023 Duke-ISCVID Criteria for Infective Endocarditis: Updating the Modified Duke Criteria. , 2023, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[2]  R. Rajani,et al.  Infective endocarditis: A contemporary update. , 2020, Clinical medicine.

[3]  D. Ley,et al.  Neonatal clinical blood sampling led to major blood loss and was associated with bronchopulmonary dysplasia , 2019, Acta paediatrica.

[4]  M. P. van der Linden,et al.  Viridans and bovis group streptococci that cause infective endocarditis in two regions with contrasting epidemiology. , 2014, International journal of medical microbiology : IJMM.

[5]  W. Coulter,et al.  Population structure and characterization of viridans group streptococci (VGS) isolated from the upper respiratory tract of patients in the community , 2013, The Ulster medical journal.

[6]  Ashish Gupta,et al.  Infective endocarditis in an Indian setup: Are we entering the ‘modern’ era? , 2013, Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine.

[7]  P. Simpson,et al.  Structural insight into the role of Streptococcus parasanguinis Fap1 within oral biofilm formation. , 2012, Biochemical and biophysical research communications.

[8]  H. Ali,et al.  Streptococcus parasanguis Peritonitis: Report of a Case and Review of the Literature , 2011, Peritoneal Dialysis International.

[9]  S. Fujitani,et al.  Penicillin G-resistant viridans group streptococcal endocarditis and interpretation of the American Heart Association's Guidelines for the Treatment of Infective Endocarditis. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[10]  F. Scannapieco,et al.  Oral biofilms, periodontitis, and pulmonary infections. , 2007, Oral diseases.

[11]  Tetsurou Yamamoto,et al.  Molecular Monitoring of the Developmental Bacterial Community in the Gastrointestinal Tract of Japanese Infants , 2005, Bioscience, biotechnology, and biochemistry.

[12]  F. Scannapieco,et al.  Associations between periodontal disease and risk for atherosclerosis, cardiovascular disease, and stroke. A systematic review. , 2003, Annals of periodontology.