Efficacy of mesotherapy with tranexamic acid and ascorbic acid with and without glutathione in treatment of melasma: A split face comparative trial

Melasma is a prevalent annoying skin hyperpigmentation disorder that commonly involves reproductive‐aged females. Variety of treatments with controversial results has been recommended. The aim of the current study was to evaluate combination therapy of tranexamic acid (TA) and vitamin C with and without glutathione with mesotherapy technique for treatment of melasma.

[1]  D. Goldberg,et al.  Energy-based device treatment of melasma: An update and review of the literature , 2017, Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology.

[2]  Nashwa N Elfar,et al.  Efficacy of Intradermal Injection of Tranexamic Acid, Topical Silymarin and Glycolic Acid Peeling in Treatment of Melasma: A Comparative Study , 2015 .

[3]  E. Hashizume,et al.  Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women , 2014, Clinical, cosmetic and investigational dermatology.

[4]  B. Ebrahimi,et al.  Topical tranexamic acid as a promising treatment for melasma , 2014, Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences.

[5]  L. Budamakuntla,et al.  A Randomised, Open-label, Comparative Study of Tranexamic Acid Microinjections and Tranexamic Acid with Microneedling in Patients with Melasma , 2013, Journal of cutaneous and aesthetic surgery.

[6]  E. Hui,et al.  Tranexamic acid: an important adjuvant in the treatment of melasma , 2013, Journal of cosmetic dermatology.

[7]  F. Iraji,et al.  Comparison between the efficacy of 10% zinc sulfate solution with 4% hydroquinone cream on improvement of melasma , 2012, Advanced biomedical research.

[8]  P. Asawanonda,et al.  Glutathione as an oral whitening agent: A randomized, double-blind, placebo-controlled study , 2012, The Journal of dermatological treatment.

[9]  P. Grimes Management of hyperpigmentation in darker racial ethnic groups. , 2009, Seminars in cutaneous medicine and surgery.

[10]  S. Feldman,et al.  Melasma and its impact on health‐related quality of life in Hispanic women , 2007, The Journal of dermatological treatment.

[11]  Francisco Solano,et al.  Hypopigmenting agents: an updated review on biological, chemical and clinical aspects. , 2006, Pigment cell research.

[12]  J. Ortonne,et al.  Guidelines for clinical trials in melasma , 2006, The British journal of dermatology.

[13]  Hyunsu Bae,et al.  Survey and mechanism of skin depigmenting and lightening agents , 2006, Phytotherapy research : PTR.

[14]  Mi-Yeon Kim,et al.  Localized Intradermal Microinjection of Tranexamic Acid for Treatment of Melasma in Asian Patients: A Preliminary Clinical Trial , 2006, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[15]  H. Maibach,et al.  Glutathione as a depigmenting agent: an overview , 2005, International journal of cosmetic science.

[16]  B. Moncada,et al.  A double‐blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma , 2004, International journal of dermatology.

[17]  M. Kavya MELASMA: A CLINICO-EPIDEMIOLOGICAL STUDY , 2014 .

[18]  M. Sriharsha,et al.  Gluthathione as a Whitening Agent in the Treatment of Melanos is on Face , 2014 .

[19]  Susan C. Taylor,et al.  Reliability assessment and validation of the Melasma Area and Severity Index (MASI) and a new modified MASI scoring method. , 2011, Journal of the American Academy of Dermatology.