The structure of GFRα1 domain 3 reveals new insights into GDNF binding and RET activation

[1]  Cheng He,et al.  Identification of the Key Amino Acids of Glial Cell Line-derived Neurotrophic Factor Family Receptor α1 Involved in Its Biological Function* , 2004, Journal of Biological Chemistry.

[2]  S. Kjær,et al.  Identification of a Surface for Binding to the GDNF-GFRα1 Complex in the First Cadherin-like Domain of RET* , 2003, Journal of Biological Chemistry.

[3]  R. Mummery,et al.  The binding of human glial cell line-derived neurotrophic factor to heparin and heparan sulfate: importance of 2-O-sulfate groups and effect on its interaction with its receptor, GFRalpha1. , 2003, Glycobiology.

[4]  T. Jardetzky,et al.  Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF‐β ligand:receptor interactions , 2003, The EMBO journal.

[5]  Mart Saarma,et al.  The GDNF family: Signalling, biological functions and therapeutic value , 2002, Nature Reviews Neuroscience.

[6]  Shashank Deep,et al.  Crystal structure of the human TβR2 ectodomain–TGF-β3 complex , 2002, Nature Structural Biology.

[7]  A. Hinck,et al.  CRYSTAL STRUCTURE OF THE HUMAN TBR2 ECTODOMAIN-TGF-B3 COMPLEX , 2002 .

[8]  S. Kjær,et al.  Molecular Modeling of the Extracellular Domain of the RET Receptor Tyrosine Kinase Reveals Multiple Cadherin-like Domains and a Calcium-binding Site* , 2001, The Journal of Biological Chemistry.

[9]  M. Saarma,et al.  Human Glial Cell Line-derived Neurotrophic Factor Receptor α4 Is the Receptor for Persephin and Is Predominantly Expressed in Normal and Malignant Thyroid Medullary Cells* , 2001, The Journal of Biological Chemistry.

[10]  R. Scott,et al.  Determinants of Ligand Binding Specificity in the Glial Cell Line-derived Neurotrophic Factor Family Receptor αs* , 2001, The Journal of Biological Chemistry.

[11]  H. Gilbert,et al.  Hormone Binding by Protein Disulfide Isomerase, a High Capacity Hormone Reservoir of the Endoplasmic Reticulum* , 2001, The Journal of Biological Chemistry.

[12]  J. Leysen,et al.  Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions. , 2000, The Journal of biological chemistry.

[13]  M. Saarma,et al.  Expression and Alternative Splicing of Mouse Gfra4 Suggest Roles in Endocrine Cell Development , 2000, Molecular and Cellular Neuroscience.

[14]  T. Kirsch,et al.  Crystal structure of the BMP-2–BRIA ectodomain complex , 2000, Nature Structural Biology.

[15]  Hideki Enomoto,et al.  The GDNF family ligands and receptors — implications for neural development , 2000, Current Opinion in Neurobiology.

[16]  J. Widom,et al.  Producing selenomethionine-labeled proteins with a baculovirus expression vector system. , 1999, Structure.

[17]  J. Murray-Rust,et al.  Distinct structural elements in GDNF mediate binding to GFRα1 and activation of the GFRα1–c‐Ret receptor complex , 1999 .

[18]  M. Saarma,et al.  GDNF Family Neurotrophic Factor Signaling: Four Masters, One Servant? , 1999, Molecular and Cellular Neuroscience.

[19]  S. Choe,et al.  Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase. , 1999, Nature Structural Biology.

[20]  J. Milbrandt,et al.  Artemin, a Novel Member of the GDNF Ligand Family, Supports Peripheral and Central Neurons and Signals through the GFRα3–RET Receptor Complex , 1998, Neuron.

[21]  A. Davies,et al.  GFRα-4 and the tyrosine kinase Ret form a functional receptor complex for persephin , 1998, Current Biology.

[22]  R J Read,et al.  Crystallography & NMR system: A new software suite for macromolecular structure determination. , 1998, Acta crystallographica. Section D, Biological crystallography.

[23]  K. Keinänen,et al.  Characterization of the kainate-binding domain of the glutamate receptor GluR-6 subunit. , 1998, The Biochemical journal.

[24]  Jimi Adu,et al.  Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase , 1997, Nature.

[25]  Charles Eigenbrot,et al.  X-ray structure of glial cell-derived neurotrophic factor at 1.9 Å resolution and implications for receptor binding , 1997, Nature Structural Biology.

[26]  R M Esnouf,et al.  An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. , 1997, Journal of molecular graphics & modelling.

[27]  Z. Otwinowski,et al.  Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.

[28]  Z. Otwinowski,et al.  [20] Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.

[29]  E A Merritt,et al.  Raster3D: photorealistic molecular graphics. , 1997, Methods in enzymology.

[30]  A. Buj-Bello,et al.  Characterization of a multicomponent receptor for GDNF , 1996, Nature.

[31]  J. Louis,et al.  GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF , 1996, Cell.

[32]  S. Grzesiek,et al.  NMRPipe: A multidimensional spectral processing system based on UNIX pipes , 1995, Journal of biomolecular NMR.

[33]  J. Thompson,et al.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. , 1994, Nucleic acids research.

[34]  C. Sander,et al.  Protein structure comparison by alignment of distance matrices. , 1993, Journal of molecular biology.

[35]  J. Lile,et al.  GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. , 1993, Science.

[36]  J. Thornton,et al.  PROCHECK: a program to check the stereochemical quality of protein structures , 1993 .

[37]  K. Sharp,et al.  Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons , 1991, Proteins.

[38]  P. Kraulis A program to produce both detailed and schematic plots of protein structures , 1991 .

[39]  J. Zou,et al.  Improved methods for building protein models in electron density maps and the location of errors in these models. , 1991, Acta crystallographica. Section A, Foundations of crystallography.