Inefficacy of internal mammary nodes dissection in breast cancer surgery

From January 1964 to January 1968, 737 patients with breast cancer were randomized at the Cancer Institute in Milan to undergo either Halsted mastectomy or Halsted mastectomy with internal mammary node dissection; 716 were considered evaluable. The series was part of an international cooperative study. The two groups of patients were comparable in age, menopausal status, quadrant distribution, and frequency of axillary metastases. No patients received postoperative radiotherapy or adjuvant treatments. At ten years, no difference was found in either in the length of disease‐free or overall survival in the two series. The overall survival was 60.7% in patients treated with Halsted mastectomy and 57.0% in patients treated with Halsted mastectomy plus internal mammary dissection. In no subgroups was a statistically significant difference found.

[1]  B. Fisher,et al.  The evolution of breast cancer surgery: past, present, and future. , 1978, Seminars in Oncology.

[2]  G. Bonadonna,et al.  Patterns of relapse and survival following radical mastectomy. Analysis of 716 consecutive patients , 1978, Cancer.

[3]  B. Fisher.  Biological and clinical considerations regarding the use of surgery and chemotherapy in the treatment of primary breast cancer , 1977, Cancer.

[4]  Eleanor Montague,et al.  Comparison of radical mastectomy with alternative treatments for primary breast cancer: A first report of results from a prospective randomized clinical trial , 1977 .

[5]  W. Donegan.  The influence of untreated internal mammary metastases upon the course of mammary cancer , 1977, Cancer.

[6]  G. Bonadonna,et al.  Combination chemotherapy as an adjuvant treatment in operable breast cancer. , 1976, The New England journal of medicine.

[7]  U. Veronesi,et al.  Radical mastectomy versus radical mastectomy plus internal mammary dissection. Five‐year results of an international cooperative study , 1976, Cancer.

[8]  J. Urban,et al.  Significance of internal mammary lymph node metastases in breast cancer. , 1971, The American journal of roentgenology, radium therapy, and nuclear medicine.

[9]  U. Veronesi,et al.  Extended mastectomy for cancer of the breast , 1967, Cancer.

[10]  N. Mantel.  Evaluation of survival data and two new rank order statistics arising in its consideration. , 1966, Cancer chemotherapy reports.

[11]  R. Handley,et al.  Invasion of Internal Mammary Lymph Nodes in Carcinoma of the Breast , 1954, British medical journal.