Chromatin Damage and Male Infertility

[1]  A. Agarwal,et al.  Selection of Nonapoptotic Spermatozoa As a New Tool for Enhancing Assisted Reproduction Outcomes: An In Vitro Model1 , 2006, Biology of reproduction.

[2]  Alberto Revelli,et al.  Intracytoplasmic sperm injection: a novel selection method for sperm with normal frequency of chromosomal aneuploidies. , 2005, Fertility and sterility.

[3]  P. Schlegel,et al.  Yet another test of sperm chromatin structure. , 2005, Fertility and sterility.

[4]  R. Aitken,et al.  Development of a novel electrophoretic system for the isolation of human spermatozoa. , 2005, Human reproduction.

[5]  E. Seli,et al.  Spermatozoal nuclear determinants of reproductive outcome: implications for ART. , 2005, Human reproduction update.

[6]  M. Spanô,et al.  The significance of sperm nuclear DNA strand breaks on reproductive outcome , 2005, Current opinion in obstetrics & gynecology.

[7]  S. Grunewald,et al.  SPERM CASPASES BECOME MORE ACTIVATED IN INFERTILITY PATIENTS THAN IN HEALTHY DONORS DURING CRYOPRESERVATION , 2005, Archives of andrology.

[8]  A. Zini,et al.  Sperm DNA integrity and male infertility. , 2005, Urology.

[9]  L. Rienzi,et al.  Efficient treatment of infertility due to sperm DNA damage by ICSI with testicular spermatozoa. , 2005, Human reproduction.

[10]  E. Seli,et al.  Extent of nuclear DNA damage in ejaculated spermatozoa impacts on blastocyst development after in vitro fertilization. , 2004, Fertility and sterility.

[11]  M. Afnan,et al.  Use of the egg-share model to investigate the paternal influence on fertilization and embryo development after in vitro fertilization and intracytoplasmic sperm injection. , 2004, Fertility and sterility.

[12]  A. Lenzi,et al.  Full-term pregnancies achieved with ICSI despite high levels of sperm chromatin damage. , 2004, Human reproduction.

[13]  M. Nijs,et al.  The presence of abnormal spermatozoa in the ejaculate: Did apoptosis fail? , 2004, Human fertility.

[14]  A. Giwercman,et al.  The predictive value of sperm chromatin structure assay (SCSA) parameters for the outcome of intrauterine insemination, IVF and ICSI. , 2004, Human reproduction.

[15]  R. Demir,et al.  Cellular maturity and apoptosis in human sperm: creatine kinase, caspase-3 and Bcl-XL levels in mature and diminished maturity sperm. , 2004, Molecular human reproduction.

[16]  M. Virro,et al.  Sperm chromatin structure assay (SCSA) parameters are related to fertilization, blastocyst development, and ongoing pregnancy in in vitro fertilization and intracytoplasmic sperm injection cycles. , 2004, Fertility and sterility.

[17]  G. Boissonneault,et al.  Transient DNA Strand Breaks During Mouse and Human Spermiogenesis: New Insights in Stage Specificity and Link to Chromatin Remodeling1 , 2004, Biology of reproduction.

[18]  Yona Barak,et al.  Pregnancy rates are higher with intracytoplasmic morphologically selected sperm injection than with conventional intracytoplasmic injection. , 2003, Fertility and sterility.

[19]  J. Brannian,et al.  Relationship between the outcomes of assisted reproductive techniques and sperm DNA fragmentation as measured by the sperm chromatin structure assay. , 2003, Fertility and sterility.

[20]  A. Agarwal,et al.  Role of sperm chromatin abnormalities and DNA damage in male infertility. , 2003, Human reproduction update.

[21]  A. Agarwal,et al.  Negative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility. , 2003, Fertility and sterility.

[22]  Ciler Celik Ozenci,et al.  Hyaluronic acid binding by human sperm indicates cellular maturity, viability, and unreacted acrosomal status. , 2003, Fertility and sterility.

[23]  J. Alvarez.  DNA fragmentation in human spermatozoa: significance in the diagnosis and treatment of infertility. , 2003, Minerva ginecologica.

[24]  J. Guérin,et al.  Sperm DNA fragmentation decreases the pregnancy rate in an assisted reproductive technique. , 2003, Human reproduction.

[25]  N. Tarozzi,et al.  Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodelling during spermatogenesis. , 2003, Reproductive biomedicine online.

[26]  S. Weng,et al.  Presence and significance of somatic cell apoptosis markers in human ejaculated spermatozoa. , 2003, Reproductive biomedicine online.

[27]  S. Korsmeyer,et al.  Bax-Dependent Spermatogonia Apoptosis Is Required for Testicular Development and Spermatogenesis1 , 2002, Biology of reproduction.

[28]  N. Tarozzi,et al.  Nature of DNA Damage in Ejaculated Human Spermatozoa and the Possible Involvement of Apoptosis1 , 2002, Biology of reproduction.

[29]  D. Brison,et al.  The spectrum of DNA damage in human sperm assessed by single cell gel electrophoresis (Comet assay) and its relationship to fertilization and embryo development. , 2002, Human reproduction.

[30]  A. Trounson,et al.  Selected genetic factors associated with male infertility. , 2002, Human reproduction update.

[31]  D. Evenson,et al.  Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. , 2002, Journal of andrology.

[32]  A Berkovitz,et al.  Selection of spermatozoa with normal nuclei to improve the pregnancy rate with intracytoplasmic sperm injection. , 2001, The New England journal of medicine.

[33]  M Afnan,et al.  Interrelationships between seminal parameters and sperm nuclear DNA damage before and after density gradient centrifugation: implications for assisted conception. , 2001, Human reproduction.

[34]  A. Agarwal,et al.  Characterization of subsets of human spermatozoa at different stages of maturation: implications in the diagnosis and treatment of male infertility. , 2001, Human reproduction.

[35]  A. Barnes,et al.  Sperm chromatin structure assay parameters as predictors of failed pregnancy following assisted reproductive techniques. , 2000, Human reproduction.

[36]  S. Oehninger,et al.  Analysis of DNA fragmentation, plasma membrane translocation of phosphatidylserine and oxidative stress in human spermatozoa. , 2000, Human reproduction.

[37]  M. Mandrioli,et al.  The use of two density gradient centrifugation techniques and the swim-up method to separate spermatozoa with chromatin and nuclear DNA anomalies. , 2000, Human reproduction.

[38]  R. Aitken,et al.  DNA integrity in human spermatozoa: relationships with semen quality. , 2000, Journal of andrology.

[39]  Jens Peter Bonde,et al.  Sperm chromatin damage impairs human fertility , 2000 .

[40]  D. Evenson,et al.  Sperm chromatin structure assay is useful for fertility assessment. , 2000, Methods in cell science : an official journal of the Society for In Vitro Biology.

[41]  D. Sakkas,et al.  Abnormal sperm parameters in humans are indicative of an abortive apoptotic mechanism linked to the Fas-mediated pathway. , 1999, Experimental cell research.

[42]  N. Mcclure,et al.  A comparison of DNA damage in testicular and proximal epididymal spermatozoa in obstructive azoospermia. , 1999, Molecular human reproduction.

[43]  E. Clegg,et al.  Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic. , 1999, Human reproduction.

[44]  C. Gagnon,et al.  The male gamete : from basic science to clinical applications , 1999 .

[45]  D. Sakkas,et al.  Origin of DNA damage in ejaculated human spermatozoa. , 1999, Reviews of reproduction.

[46]  Irene Garcia,et al.  An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis , 1997, The EMBO journal.

[47]  V. McKelvey-Martin,et al.  A comparison of baseline and induced DNA damage in human spermatozoa from fertile and infertile men, using a modified comet assay. , 1996, Molecular human reproduction.

[48]  T. Furuchi,et al.  Inhibition of testicular germ cell apoptosis and differentiation in mice misexpressing Bcl-2 in spermatogonia. , 1996, Development.

[49]  D. Sakkas,et al.  Relationship between the presence of endogenous nicks and sperm chromatin packaging in maturing and fertilizing mouse spermatozoa. , 1995, Biology of reproduction.

[50]  F. Longo,et al.  Nicking of rat spermatid and spermatozoa DNA: possible involvement of DNA topoisomerase II. , 1993, Developmental biology.

[51]  F. Longo,et al.  Chromatin structure-function alterations during mammalian spermatogenesis: DNA nicking and repair in elongating spermatids. , 1993, European journal of histochemistry : EJH.

[52]  F. Longo,et al.  Localization of DNase I‐hypersensitive regions during rat spermatogenesis: Stage‐dependent patterns and unique sensitivity of elongating spermatids , 1992, Molecular reproduction and development.

[53]  D. S. Coffey,et al.  DNA packaging and organization in mammalian spermatozoa: comparison with somatic cells. , 1991, Biology of reproduction.

[54]  P. Caron,et al.  The role of DNA topoisomerases in recombination and genome stability: A double-edged sword? , 1990, Cell.

[55]  M. Melamed,et al.  Relation of mammalian sperm chromatin heterogeneity to fertility. , 1980, Science.