Insulin signalling and the regulation of glucose and lipid metabolism

[1]  Daniel A. Pollard,et al.  Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α , 2000, Nature Genetics.

[2]  G. Shulman,et al.  Prevention of fat-induced insulin resistance by salicylate. , 2001, The Journal of clinical investigation.

[3]  A. Klip,et al.  Glucose Transport and Glucose Transporters in Muscle and Their Metabolic Regulation , 1990, Diabetes Care.

[4]  Guillaume Adelmant,et al.  Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 , 2001, Nature.

[5]  G. Thomas,et al.  TOR signalling and control of cell growth. , 1997, Current opinion in cell biology.

[6]  R. Klein,et al.  Role of brain insulin receptor in control of body weight and reproduction. , 2006, Science.

[7]  A. Nairn,et al.  The Regulation of Glycogen Synthase by Protein Phosphatase 1 in 3T3-L1 Adipocytes , 1997, The Journal of Biological Chemistry.

[8]  C. Kahn,et al.  Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene , 1994, Nature.

[9]  Roy Taylor,et al.  Effects of an Engineered Human Anti–TNF-α Antibody (CDP571) on Insulin Sensitivity and Glycemic Control in Patients With NIDDM , 1996, Diabetes.

[10]  G. Shulman,et al.  On Diabetes: Insulin Resistance Cellular Mechanisms of Insulin Resistance , 2022 .

[11]  W. Müller,et al.  Origin of insulin receptor-like tyrosine kinases in marine sponges. , 1999, The Biological bulletin.

[12]  R. Unger,et al.  Liporegulation in Diet-induced Obesity , 2001, The Journal of Biological Chemistry.

[13]  Ziegler Sf,et al.  Molecular Cloning and Characterization of a Novel Receptor Protein Tyrosine Kinase From Human Placenta , 1993 .

[14]  H. Lodish,et al.  Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[15]  B. Kay,et al.  A Role for CAP, a Novel, Multifunctional Src Homology 3 Domain-containing Protein in Formation of Actin Stress Fibers and Focal Adhesions* , 1998, The Journal of Biological Chemistry.

[16]  S. Lietzke,et al.  Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains. , 2000, Molecular cell.

[17]  P. Cohen,et al.  Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B , 1995, Nature.

[18]  T. Yagi,et al.  Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 , 1994, Nature.

[19]  D. Accili,et al.  Targeted Gene Mutations Define the Roles of Insulin and IGF-I Receptors in Mouse Embryonic Development , 1999, Journal of pediatric endocrinology & metabolism : JPEM.

[20]  Makoto Kanzaki,et al.  Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10 , 2001, Nature.

[21]  U. Smith,et al.  Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle. , 2001, Biochemical and biophysical research communications.

[22]  K. Siddle,et al.  Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase. , 1995, The Biochemical journal.

[23]  P. Cuatrecasas,et al.  Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin (*) , 1995, The Journal of Biological Chemistry.

[24]  S. Schreiber,et al.  Kinase phosphorylation: Keeping it all in the family , 1999, Current Biology.

[25]  N. Sonenberg,et al.  The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila , 2001, Nature Cell Biology.

[26]  A. Stenbit,et al.  Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4 , 1995, Nature.

[27]  H. Ishihara,et al.  Role of the Src Homology 2 (SH2) Domain and C-Terminus Tyrosine Phosphorylation Sites of SH2-Containing Inositol Phosphatase (SHIP) in the Regulation of Insulin-Induced Mitogenesis1. , 1999, Endocrinology.

[28]  Nancy Y. Ip,et al.  ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF , 1991, Cell.

[29]  S. Ziegler,et al.  Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta. , 1993, Oncogene.

[30]  G. Ruvkun,et al.  The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. , 1998, Molecular cell.

[31]  Steven L. Cohen,et al.  Weight-reducing effects of the plasma protein encoded by the obese gene. , 1995, Science.

[32]  Jullie W Pan,et al.  Regional differences in intramyocellular lipids in humans observed by in vivo 1H-MR spectroscopic imaging. , 2001, Journal of applied physiology.

[33]  Y. Kido,et al.  Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. , 2000, The Journal of clinical investigation.

[34]  C. Kahn,et al.  Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. , 2000, Molecular cell.

[35]  C. Kahn,et al.  Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. , 1997, The Journal of clinical investigation.

[36]  G. Shulman,et al.  Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. , 2000, The Journal of clinical investigation.

[37]  B. Spiegelman,et al.  IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance , 1996, Science.

[38]  R. Farese,et al.  Protein Kinase C-ζ as a Downstream Effector of Phosphatidylinositol 3-Kinase during Insulin Stimulation in Rat Adipocytes , 1997, The Journal of Biological Chemistry.

[39]  A. Gingras,et al.  The target of rapamycin (TOR) proteins , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[40]  A. Saltiel,et al.  Signaling pathways in insulin action: molecular targets of insulin resistance. , 2000, The Journal of clinical investigation.

[41]  K. Ueki,et al.  Insulin Receptor Substrate 3 (IRS-3) and IRS-4 Impair IRS-1- and IRS-2-Mediated Signaling , 2001, Molecular and Cellular Biology.

[42]  J. Leszyk,et al.  Perinuclear Localization and Insulin Responsiveness of GLUT4 Requires Cytoskeletal Integrity in 3T3-L1 Adipocytes* , 2000, The Journal of Biological Chemistry.

[43]  R. Hammer,et al.  Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. , 2000, Molecular cell.

[44]  K. Kaestner,et al.  Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ) , 2001 .

[45]  Y. Matsuzawa,et al.  Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase , 1999, Nature Genetics.

[46]  M. White,et al.  Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase , 1996, Molecular and cellular biology.

[47]  R. O’Brien,et al.  New connections in the regulation of PEPCK gene expression by insulin. , 1996, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[48]  A. Kessler,et al.  Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase. , 2001, American journal of physiology. Endocrinology and metabolism.

[49]  C. Dina,et al.  Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. , 2000, American journal of human genetics.

[50]  J. Klein,et al.  Essential Role of Insulin Receptor Substrate 1 in Differentiation of Brown Adipocytes , 2001, Molecular and Cellular Biology.

[51]  D. Accili,et al.  Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway* , 1999, The Journal of Biological Chemistry.

[52]  A. Craparo,et al.  14-3-3 (ε) Interacts with the Insulin-like Growth Factor I Receptor and Insulin Receptor Substrate I in a Phosphoserine-dependent Manner* , 1997, The Journal of Biological Chemistry.

[53]  B. Spiegelman,et al.  ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose , 1999, Molecular and Cellular Biology.

[54]  I. Shimomura,et al.  Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[55]  J. Pessin,et al.  Molecular Basis of Insulin-stimulated GLUT4 Vesicle Trafficking , 1999, The Journal of Biological Chemistry.

[56]  M. Stern.  Strategies and prospects for finding insulin resistance genes. , 2000, The Journal of clinical investigation.

[57]  R. Hammer,et al.  Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy , 1999, Nature.

[58]  M. Magnuson,et al.  Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase* , 1999, The Journal of Biological Chemistry.

[59]  C. Kahn,et al.  Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes , 1999, Cell.

[60]  Michael Karin,et al.  Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ , 2001, Science.

[61]  C. Wernstedt,et al.  Identification of Novel Phosphorylation Sites in Hormone-sensitive Lipase That Are Phosphorylated in Response to Isoproterenol and Govern Activation Properties in Vitro * , 1998, The Journal of Biological Chemistry.

[62]  C. Kahn,et al.  Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. , 2000, The Journal of clinical investigation.

[63]  D. Leroith,et al.  Printed in U.S.A. Copyright © 2001 by The Endocrine Society Minireview: Tissue-Specific Versus Generalized Gene Targeting of the igf1 and igf1r Genes and Their Roles in Insulin-Like Growth Factor Physiology , 2022 .

[64]  D. Alessi,et al.  Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. , 1999, The Biochemical journal.

[65]  Simeon I. Taylor,et al.  Syndromes Associated with Insulin Resistance and Acanthosis Nigricans , 1998, Journal of basic and clinical physiology and pharmacology.

[66]  T. Kodama,et al.  Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease. , 1997, The Journal of clinical investigation.

[67]  H. Ishihara,et al.  Role of the Src homology 2 (SH2) domain and C-terminus tyrosine phosphorylation sites of SH2-containing inositol phosphatase (SHIP) in the regulation of insulin-induced mitogenesis. , 1999, Endocrinology.

[68]  M. White,et al.  The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase , 1995, Molecular and cellular biology.

[69]  A. Saltiel,et al.  Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes. , 1997, The Biochemical journal.

[70]  M. White,et al.  IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[71]  L. Cantley,et al.  Structural Organization and Alternative Splicing of the Murine Phosphoinositide 3-Kinase p85α Gene , 1996 .

[72]  C. Kahn,et al.  The Insulin Receptor - A Critical Link in Glucose Homeostasis and Insulin Action , 1998, Journal of basic and clinical physiology and pharmacology.

[73]  P. Cohen,et al.  Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα , 1997, Current Biology.

[74]  S. Schurmans,et al.  The lipid phosphatase SHIP2 controls insulin sensitivity , 2001, Nature.

[75]  G. Shulman,et al.  Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[76]  D. Hanahan,et al.  Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. , 1999, The Journal of clinical investigation.

[77]  G. Lienhard,et al.  Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis. , 2000, American journal of physiology. Endocrinology and metabolism.

[78]  A. Saltiel,et al.  The sorbin homology domain: A motif for the targeting of proteins to lipid rafts , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[79]  C. Kahn,et al.  Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance , 2000, Nature Medicine.

[80]  L. Cantley,et al.  Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene. , 1996, Genomics.

[81]  G. Shulman,et al.  Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver , 2001, Nature.

[82]  C. Kahn,et al.  Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain , 1996, Molecular and cellular biology.

[83]  C. Kahn,et al.  Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. , 2000, The Journal of clinical investigation.

[84]  Margaret S. Wu,et al.  Targeted Disruption of the Tumor Necrosis Factor-α Gene: Metabolic Consequences in Obese and Nonobese Mice , 1997, Diabetes.

[85]  G. Shulman,et al.  Disruption of IRS-2 causes type 2 diabetes in mice , 1998, Nature.

[86]  Y. Terauchi,et al.  The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity , 2001, Nature Medicine.

[87]  B. Kennedy,et al.  Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. , 1999, Science.

[88]  C. Kahn,et al.  Erratum: Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene (Nature (1994) 372 (186-190)) , 1994 .

[89]  M. Kanzaki,et al.  CAP defines a second signalling pathway required for insulin-stimulated glucose transport , 2000, Nature.

[90]  C. Kahn,et al.  Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles , 1997, Cell.

[91]  D. Granner,et al.  Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. , 1992, Annual review of physiology.

[92]  P. Scherer,et al.  The adipocyte-secreted protein Acrp30 enhances hepatic insulin action , 2001, Nature Medicine.

[93]  C. Kahn,et al.  A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. , 1998, Molecular cell.

[94]  W Ogawa,et al.  Insulin-Induced Phosphorylation and Activation of Cyclic Nucleotide Phosphodiesterase 3B by the Serine-Threonine Kinase Akt , 1999, Molecular and Cellular Biology.

[95]  M. Lazar,et al.  A family of tissue-specific resistin-like molecules. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[96]  M. Kanzaki,et al.  Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation , 2001, The Journal of cell biology.

[97]  A. Kessler,et al.  Diversification of cardiac insulin signaling involves the p85α/β subunits of phosphatidylinositol 3-kinase , 2001 .

[98]  A. Saltiel,et al.  The Activation of Glycogen Synthase by Insulin Switches from Kinase Inhibition to Phosphatase Activation during Adipogenesis in 3T3-L1 Cells* , 1998, The Journal of Biological Chemistry.

[99]  M. Kanzaki,et al.  Insulin-stimulated GLUT 4 translocation requires the CAP-dependent activation of TC 10 , 2001 .

[100]  C. Newgard,et al.  Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1. , 2000, Diabetes.

[101]  R. Bergman.  New concepts in extracellular signaling for insulin action: the single gateway hypothesis. , 1997, Recent progress in hormone research.

[102]  R. Bergman,et al.  Free Fatty Acids and Pathogenesis of Type 2 Diabetes Mellitus , 2000, Trends in Endocrinology & Metabolism.

[103]  J. H. Johnson,et al.  Thiazolidinediones and insulin resistance: peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene. , 1998, Proceedings of the National Academy of Sciences of the United States of America.