Complement C5a receptor and polymorphonuclear neutrophils- accomplices in atherosclerotic lesion formation

[1]  D. Gabrilovich The Neutrophils:New Outlook for Old Cells , 2013 .

[2]  I. Chapple,et al.  Extracellular deoxyribonuclease production by periodontal bacteria. , 2012, Journal of periodontal research.

[3]  R. Lande,et al.  Role of defensins and cathelicidin LL37 in auto-immune and auto-inflammatory diseases. , 2012, Current pharmaceutical biotechnology.

[4]  M. Sieńczyk,et al.  Human neutrophil elastase phosphonic inhibitors with improved potency of action. , 2012, Journal of medicinal chemistry.

[5]  C. Weber,et al.  Lack of Neutrophil-Derived CRAMP Reduces Atherosclerosis in Mice , 2012, Circulation research.

[6]  K. Peter,et al.  HMGB1 signals danger in acute coronary syndrome: emergence of a new risk marker for cardiovascular death? , 2012, Atherosclerosis.

[7]  A. Blom,et al.  Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease , 2012, The Journal of Immunology.

[8]  M. Noverr,et al.  Cytokines in the host response to Candida vaginitis: Identifying a role for non-classical immune mediators, S100 alarmins. , 2012, Cytokine.

[9]  A. Zychlinsky,et al.  Neutrophil function: from mechanisms to disease. , 2012, Annual review of immunology.

[10]  Oliver Soehnlein,et al.  Multiple roles for neutrophils in atherosclerosis. , 2012, Circulation research.

[11]  C. Weber,et al.  Presence of luminal neutrophil extracellular traps in atherosclerosis , 2012, Thrombosis and Haemostasis.

[12]  Ash A. Alizadeh,et al.  Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies , 2012, Arthritis Research & Therapy.

[13]  K. Bornfeldt,et al.  S100A8 and S100A9 in cardiovascular biology and disease. , 2012, Arteriosclerosis, thrombosis, and vascular biology.

[14]  A. Zychlinsky,et al.  Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy , 2011, PloS one.

[15]  E. Pamer,et al.  Monocyte recruitment during infection and inflammation , 2011, Nature Reviews Immunology.

[16]  C. Weber,et al.  Atherosclerosis: current pathogenesis and therapeutic options , 2011, Nature Medicine.

[17]  P. Kubes,et al.  The neutrophil in vascular inflammation , 2011, Nature Medicine.

[18]  P. Hundelshausen,et al.  Platelets in atherosclerosis , 2011, Thrombosis and Haemostasis.

[19]  O. Soehnlein,et al.  Neutrophilic granulocytes – promiscuous accelerators of atherosclerosis , 2011, Thrombosis and Haemostasis.

[20]  T. Gries,et al.  Neutrophil-Derived Cathelicidin Protects from Neointimal Hyperplasia , 2011, Science Translational Medicine.

[21]  Carolyn L. Geczy,et al.  Inflammation-associated S100 proteins: new mechanisms that regulate function , 2011, Amino Acids.

[22]  G. Srikrishna S100A8 and S100A9: New Insights into Their Roles in Malignancy , 2011, Journal of Innate Immunity.

[23]  Scott H. Randell,et al.  Neutrophil Extracellular Trap (NET)-Mediated Killing of Pseudomonas aeruginosa: Evidence of Acquired Resistance within the CF Airway, Independent of CFTR , 2011, PloS one.

[24]  G. Schmitz,et al.  Oxidized LDL-induced endolysosomal phospholipidosis and enzymatically modified LDL-induced foam cell formation determine specific lipid species modulation in human macrophages. , 2011, Chemistry and physics of lipids.

[25]  M. Raftery,et al.  Oxidative modifications of DAMPs suppress inflammation: the case for S100A8 and S100A9. , 2011, Antioxidants & redox signaling.

[26]  D. Pisetsky Cell death in the pathogenesis of immune-mediated diseases: the role of HMGB1 and DAMP-PAMP complexes. , 2011, Swiss medical weekly.

[27]  Alberto Mantovani,et al.  Neutrophils in the activation and regulation of innate and adaptive immunity , 2011, Nature Reviews Immunology.

[28]  Kutty Selva Nandakumar,et al.  Inhibiting the C5-C5a receptor axis. , 2011, Molecular immunology.

[29]  A. Zernecke,et al.  Complement C5a inhibition reduces atherosclerosis in ApoE–/– mice , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[30]  H. Itabe,et al.  The Dynamics of Oxidized LDL during Atherogenesis , 2011, Journal of lipids.

[31]  B. Amulic,et al.  Neutrophil extracellular traps , 2011, Current Biology.

[32]  W. Grizzle,et al.  LL‐37 as a therapeutic target for late stage prostate cancer , 2011, The Prostate.

[33]  Hartmut Jaeschke,et al.  Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products. , 2011, Life sciences.

[34]  B. Lambrecht,et al.  Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation. , 2011, Trends in immunology.

[35]  P. Vandenabeele,et al.  Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality , 2011, Cell Death and Differentiation.

[36]  J. Wojta,et al.  Complement in atherosclerosis: friend or foe? , 2011, Journal of thrombosis and haemostasis : JTH.

[37]  G. Hansson,et al.  The immune system in atherosclerosis , 2011, Nature Immunology.

[38]  M. Lamkanfi Emerging inflammasome effector mechanisms , 2011, Nature Reviews Immunology.

[39]  Paul C. Evans,et al.  The role of blood flow in determining the sites of atherosclerotic plaques , 2011, F1000 medicine reports.

[40]  K. Peter,et al.  High-Mobility Group Box Protein 1 Neutralization Reduces Development of Diet-Induced Atherosclerosis in Apolipoprotein E–Deficient Mice , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[41]  W. Rom,et al.  Neutrophils Activate Alveolar Macrophages by Producing Caspase-6–Mediated Cleavage of IL-1 Receptor-Associated Kinase-M , 2011, The Journal of Immunology.

[42]  J. Badimón,et al.  The complement component C5a is present in human coronary lesions in vivo and induces the expression of MMP‐1 and MMP‐9 in human macrophages in vitro , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[43]  E. Carlson,et al.  Human Biology and Health , 2009, The Quarterly Review of Biology.

[44]  P. Ward Role of C5 Activation Products in Sepsis , 2010, TheScientificWorldJournal.

[45]  P. Marrack,et al.  Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo. , 2010, Blood.

[46]  W. Kahr Complement halts angiogenesis gone wild. , 2010, Blood.

[47]  N. Borregaard,et al.  Neutrophils, from marrow to microbes. , 2010, Immunity.

[48]  Oliver Soehnlein,et al.  Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis , 2010, Circulation.

[49]  Abdul Hakkim,et al.  Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps , 2010, The Journal of cell biology.

[50]  Silvano Sozzani,et al.  Nomenclature of monocytes and dendritic cells in blood. , 2010, Blood.

[51]  J. Casanova,et al.  Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors , 2010, Immunity.

[52]  C. Czuprynski,et al.  Mannheimia haemolytica and Its Leukotoxin Cause Neutrophil Extracellular Trap Formation by Bovine Neutrophils , 2010, Infection and Immunity.

[53]  H. L. Wright,et al.  Neutrophil function in inflammation and inflammatory diseases. , 2010, Rheumatology.

[54]  J. Wiesner,et al.  Antimicrobial peptides: The ancient arm of the human immune system , 2010, Virulence.

[55]  J. Hartwig,et al.  Extracellular DNA traps promote thrombosis , 2010, Proceedings of the National Academy of Sciences.

[56]  A. Zernecke,et al.  C5a Receptor Targeting in Neointima Formation After Arterial Injury in Atherosclerosis-Prone Mice , 2010, Circulation.

[57]  W. Ruf,et al.  Neutrophils release brakes of coagulation , 2010, Nature Medicine.

[58]  K. Preissner,et al.  Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases , 2010, Nature Medicine.

[59]  O. Soehnlein,et al.  Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice. , 2010, The American journal of pathology.

[60]  O. Soehnlein,et al.  Phagocyte partnership during the onset and resolution of inflammation , 2010, Nature Reviews Immunology.

[61]  A. Corsini,et al.  Role of polymorphonuclear neutrophils in atherosclerosis: current state and future perspectives. , 2010, Atherosclerosis.

[62]  K. Hartshorn,et al.  Review: Defensins and cathelicidins in lung immunity , 2010, Innate immunity.

[63]  M. Gobbi,et al.  Regulation of leukocyte recruitment by the long pentraxin PTX3 , 2010, Nature Immunology.

[64]  S. Zhu,et al.  Silencing of C5a receptor gene with siRNA for protection from Gram-negative bacterial lipopolysaccharide-induced vascular permeability. , 2010, Molecular immunology.

[65]  A. Zychlinsky,et al.  Neutrophil Extracellular Traps: How to Generate and Visualize Them , 2010, Journal of visualized experiments : JoVE.

[66]  Markus G. Manz,et al.  Development of Monocytes, Macrophages, and Dendritic Cells , 2010, Science.

[67]  C. Garlanda,et al.  The long pentraxin PTX3: a modulator of the immunoinflammatory response in atherosclerosis and cardiovascular diseases. , 2010, Trends in cardiovascular medicine.

[68]  A. Iwasaki,et al.  Regulation of Adaptive Immunity by the Innate Immune System , 2010, Science.

[69]  C. Hermosilla,et al.  Neutrophil extracellular trap formation as innate immune reactions against the apicomplexan parasite Eimeria bovis. , 2010, Veterinary immunology and immunopathology.

[70]  K. Leszczynska,et al.  Cathelicidin LL-37: A Multitask Antimicrobial Peptide , 2010, Archivum Immunologiae et Therapiae Experimentalis.

[71]  C. Mackay,et al.  The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction* , 2009, The Journal of Biological Chemistry.

[72]  P. Steel,et al.  The chemistry and biology of LL-37. , 2009, Natural product reports.

[73]  G. de la Rosa,et al.  Alarmins link neutrophils and dendritic cells. , 2009, Trends in immunology.

[74]  M. Fishbein,et al.  Natural antibodies and complement modulate intimal thickening after arterial injury. , 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

[75]  A. Zychlinsky,et al.  NETs: a new strategy for using old weapons. , 2009, Trends in immunology.

[76]  M. Hristov,et al.  Functional alterations of myeloid cell subsets in hyperlipidaemia: relevance for atherosclerosis , 2009, Journal of cellular and molecular medicine.

[77]  C. Weber,et al.  Neutrophil granule proteins tune monocytic cell function. , 2009, Trends in immunology.

[78]  K. Ley,et al.  Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability. , 2009, Trends in immunology.

[79]  W. Nacken,et al.  Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans , 2009, PLoS pathogens.

[80]  Takashi Ito,et al.  Nucleophosmin may act as an alarmin: implications for severe sepsis , 2009, Journal of leukocyte biology.

[81]  J. Cinatl,et al.  The clinical value of neutrophil extracellular traps , 2009, Medical Microbiology and Immunology.

[82]  N. McElvaney,et al.  LL-37 Complexation with Glycosaminoglycans in Cystic Fibrosis Lungs Inhibits Antimicrobial Activity, Which Can Be Restored by Hypertonic Saline1 , 2009, The Journal of Immunology.

[83]  Marc Parmentier,et al.  International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family , 2009, Pharmacological Reviews.

[84]  J. Haeggström,et al.  Leukotriene B4‐ induced changes in vascular permeability are mediated by neutrophil release of heparin‐binding protein (HBP/CAP37/azurocidin) , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[85]  Z. Werb,et al.  Netting neutrophils in autoimmune small-vessel vasculitis , 2009, Nature Medicine.

[86]  J. Ostojić,et al.  Chicken heterophil extracellular traps (HETs): novel defense mechanism of chicken heterophils. , 2009, Veterinary immunology and immunopathology.

[87]  Graham M Lord,et al.  In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses , 2009, Proceedings of the National Academy of Sciences.

[88]  A. Pivarcsi,et al.  The human antimicrobial peptide LL-37 suppresses apoptosis in keratinocytes. , 2009, The Journal of investigative dermatology.

[89]  K. Ley,et al.  Immune and inflammatory mechanisms of atherosclerosis (*). , 2009, Annual review of immunology.

[90]  L. Zakharova Evolution of adaptive immunity , 2009, Biology Bulletin.

[91]  R. Gallo,et al.  AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. , 2009, Trends in immunology.

[92]  P. Monk,et al.  The human complement fragment receptor, C5L2, is a recycling decoy receptor , 2009, Molecular immunology.

[93]  Richard A. Juneau,et al.  Survival of Bacterial Biofilms within Neutrophil Extracellular Traps Promotes Nontypeable Haemophilus influenzae Persistence in the Chinchilla Model for Otitis Media , 2009, Journal of Innate Immunity.

[94]  C. Weber,et al.  Myeloid cells in atherosclerosis: initiators and decision shapers , 2009, Seminars in Immunopathology.

[95]  H. Herwald,et al.  Activation of the Human Contact System on Neutrophil Extracellular Traps , 2009, Journal of Innate Immunity.

[96]  P. Ward Functions of C5a receptors , 2009, Journal of Molecular Medicine.

[97]  C. Allis,et al.  Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation , 2009, The Journal of cell biology.

[98]  R. Hancock,et al.  The roles of cathelicidin LL-37 in immune defences and novel clinical applications , 2009, Current opinion in hematology.

[99]  P. Monk,et al.  The Complement Factor C5a Contributes to Pathology in a Rat Model of Amyotrophic Lateral Sclerosis1 , 2008, The Journal of Immunology.

[100]  R. Koenen,et al.  The chemokine system as therapeutic target in cardiovascular disease , 2008 .

[101]  K. Schnatbaum,et al.  Complement 5a receptor inhibition improves renal allograft survival. , 2008, Journal of the American Society of Nephrology : JASN.

[102]  J. Edwards,et al.  Exploring the full spectrum of macrophage activation , 2008, Nature Reviews Immunology.

[103]  Christian Weber,et al.  Chemokines in Atherosclerosis , Thrombosis , and Vascular Biology Series Editor : Christian Weber Chemokines in Atherosclerosis An Update , 2008 .

[104]  K. Ley,et al.  Homeostatic Regulation of Blood Neutrophil Counts , 2008, The Journal of Immunology.

[105]  P. Libby,et al.  The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models , 2008, Nature Reviews Immunology.

[106]  Motohiko Suzuki,et al.  Gene silencing of complement C5a receptor using siRNA for preventing ischemia/reperfusion injury. , 2008, The American journal of pathology.

[107]  O. Soehnlein,et al.  Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages. , 2008, The Journal of clinical investigation.

[108]  J. Boyle,et al.  The role of complement in atherosclerosis , 2008, Current opinion in lipidology.

[109]  Arthur S Slutsky,et al.  Human neutrophil peptides: a novel potential mediator of inflammatory cardiovascular diseases. , 2008, American journal of physiology. Heart and circulatory physiology.

[110]  C. Mackay,et al.  Moving targets: cell migration inhibitors as new anti-inflammatory therapies , 2008, Nature Immunology.

[111]  A. Zernecke,et al.  Neutrophil secretion products pave the way for inflammatory monocytes. , 2008, Blood.

[112]  M. Capogrossi,et al.  HMGB1-stimulated human primary cardiac fibroblasts exert a paracrine action on human and murine cardiac stem cells. , 2008, Journal of molecular and cellular cardiology.

[113]  Manfred Rohde,et al.  Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation. , 2008, Blood.

[114]  J. Sallenave,et al.  Neutrophil elastase (NE) and NE inhibitors: canonical and noncanonical functions in lung chronic inflammatory diseases (cystic fibrosis and chronic obstructive pulmonary disease). , 2008, Journal of aerosol medicine and pulmonary drug delivery.

[115]  C. Mackay,et al.  Functional roles for C5a receptors in sepsis , 2008, Nature Medicine.

[116]  M. Radic,et al.  Histone Deimination As a Response to Inflammatory Stimuli in Neutrophils1 , 2008, The Journal of Immunology.

[117]  John D. Lambris,et al.  Complement evasion by human pathogens , 2008, Nature Reviews Microbiology.

[118]  C. Mackay,et al.  Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2 , 2008, Immunology and cell biology.

[119]  O. Soehnlein,et al.  Neutrophil secretion products regulate anti‐bacterial activity in monocytes and macrophages , 2007, Clinical and experimental immunology.

[120]  S. Gordon The macrophage: Past, present and future , 2007, European journal of immunology.

[121]  John D Lambris,et al.  Complement-targeted therapeutics , 2007, Nature Biotechnology.

[122]  I. Mellman,et al.  Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide , 2007, Nature.

[123]  P. Monk,et al.  Function, structure and therapeutic potential of complement C5a receptors , 2007, British journal of pharmacology.

[124]  M. Lotze,et al.  Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox. , 2007, Trends in immunology.

[125]  John D Lambris,et al.  The role of complement in inflammatory diseases from behind the scenes into the spotlight. , 2007, The American journal of pathology.

[126]  N. Borregaard,et al.  Neutrophil granules: a library of innate immunity proteins. , 2007, Trends in immunology.

[127]  Volker Brinkmann,et al.  Beneficial suicide: why neutrophils die to make NETs , 2007, Nature Reviews Microbiology.

[128]  G. Qin,et al.  C5aR-mediated myocardial ischemia/reperfusion injury. , 2007, Biochemical and biophysical research communications.

[129]  P. Boor,et al.  Complement C5 mediates experimental tubulointerstitial fibrosis. , 2007, Journal of the American Society of Nephrology : JASN.

[130]  S. Meri,et al.  Function and regulation of the complement system in cardiovascular diseases. , 2007, Frontiers in bioscience : a journal and virtual library.

[131]  Stephen R. Clark,et al.  Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood , 2007, Nature Medicine.

[132]  C. McKerlie,et al.  C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a , 2007, Nature.

[133]  S. Normark,et al.  Neutrophil extracellular traps: casting the NET over pathogenesis. , 2007, Current opinion in microbiology.

[134]  D. Schrijvers,et al.  Phagocytosis in atherosclerosis: Molecular mechanisms and implications for plaque progression and stability. , 2007, Cardiovascular research.

[135]  O. Wagner,et al.  Complement Component C5a Predicts Restenosis after Superficial Femoral Artery Balloon Angioplasty , 2007, Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists.

[136]  V. Wahn,et al.  Novel cell death program leads to neutrophil extracellular traps. , 2007, The Journal of cell biology.

[137]  M. Bianchi DAMPs, PAMPs and alarmins: all we need to know about danger , 2007, Journal of leukocyte biology.

[138]  D. Link,et al.  Regulation of neutrophil homeostasis , 2007, Current opinion in hematology.

[139]  A. Maseri,et al.  Smooth muscle cells in human atherosclerotic plaques secrete and proliferate in response to high mobility group box 1 protein , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[140]  S. Colgan,et al.  ATP Release From Activated Neutrophils Occurs via Connexin 43 and Modulates Adenosine-Dependent Endothelial Cell Function , 2006, Circulation research.

[141]  A. Zychlinsky,et al.  How do microbes evade neutrophil killing? , 2006, Cellular microbiology.

[142]  Ayyalusamy Ramamoorthy,et al.  LL-37, the only human member of the cathelicidin family of antimicrobial peptides. , 2006, Biochimica et biophysica acta.

[143]  M. Parseghian,et al.  Beyond the walls of the nucleus: the role of histones in cellular signaling and innate immunity. , 2006, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[144]  K. Mandal,et al.  Involvement of the Antimicrobial Peptide LL-37 in Human Atherosclerosis , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[145]  Christine T. N. Pham,et al.  Neutrophil serine proteases: specific regulators of inflammation , 2006, Nature Reviews Immunology.

[146]  G. Laurent,et al.  Neutrophil elastase: mediator of extracellular matrix destruction and accumulation. , 2006, Proceedings of the American Thoracic Society.

[147]  John D Lambris,et al.  Generation of C5a in the absence of C3: a new complement activation pathway , 2006, Nature Medicine.

[148]  Haichao Wang,et al.  Role of HMGB1 in cardiovascular diseases. , 2006, Current opinion in pharmacology.

[149]  Arturo Zychlinsky,et al.  An Endonuclease Allows Streptococcus pneumoniae to Escape from Neutrophil Extracellular Traps , 2006, Current Biology.

[150]  Pixu Liu,et al.  An Anti-inflammatory Function for the Complement Anaphylatoxin C5a-binding Protein, C5L2* , 2005, Journal of Biological Chemistry.

[151]  S. Gordon,et al.  Monocyte and macrophage heterogeneity , 2005, Nature Reviews Immunology.

[152]  K. Ley,et al.  Macrophage differentiation to foam cells. , 2005, Current pharmaceutical design.

[153]  Jonas Larsson,et al.  The role of Smad signaling in hematopoiesis , 2005, Oncogene.

[154]  S. Tomlins,et al.  Evidence for a functional role of the second C5a receptor C5L2 , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[155]  F. Yarovinsky,et al.  Mouse Cathelin-Related Antimicrobial Peptide Chemoattracts Leukocytes Using Formyl Peptide Receptor-Like 1/Mouse Formyl Peptide Receptor-Like 2 as the Receptor and Acts as an Immune Adjuvant1 , 2005, The Journal of Immunology.

[156]  S. Klebanoff Myeloperoxidase: friend and foe , 2005, Journal of leukocyte biology.

[157]  C. Reardon,et al.  The unusual suspects: an overview of the minor leukocyte populations in atherosclerosis , 2005 .

[158]  J. Borlak,et al.  Complement C3 is required for the progression of cutaneous lesions and neutrophil attraction in Leishmania major infection , 2005, Medical Microbiology and Immunology.

[159]  P. Hiemstra,et al.  Interactions between neutrophil‐derived antimicrobial peptides and airway epithelial cells , 2005, Journal of leukocyte biology.

[160]  D. Davidson,et al.  Impact of LL‐37 on anti‐infective immunity , 2005, Journal of leukocyte biology.

[161]  P. Monk,et al.  Changes in the Novel Orphan, C5a Receptor (C5L2), during Experimental Sepsis and Sepsis in Humans1 , 2005, The Journal of Immunology.

[162]  M. Flajnik,et al.  Evolution of innate and adaptive immunity: can we draw a line? , 2004, Trends in immunology.

[163]  B. Beutler,et al.  The interface between innate and adaptive immunity , 2004, Nature Immunology.

[164]  L. Romani Immunity to fungal infections , 2004, Nature Reviews Immunology.

[165]  S. Akira,et al.  Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[166]  E. Eklund,et al.  The Human Antimicrobial Peptide LL-37 Transfers Extracellular DNA Plasmid to the Nuclear Compartment of Mammalian Cells via Lipid Rafts and Proteoglycan-dependent Endocytosis* , 2004, Journal of Biological Chemistry.

[167]  M. Wewers,et al.  A Novel P2X7 Receptor Activator, the Human Cathelicidin-Derived Peptide LL37, Induces IL-1β Processing and Release1 , 2004, The Journal of Immunology.

[168]  A. Zychlinsky,et al.  Neutrophil Extracellular Traps Kill Bacteria , 2004, Science.

[169]  W. Busse,et al.  Oxidized low-density lipoprotein activates migration and degranulation of human granulocytes. , 2003, American journal of respiratory cell and molecular biology.

[170]  N. Borregaard,et al.  Neutrophil granules and secretory vesicles in inflammation. , 2003, Microbes and infection.

[171]  C. Lewis,et al.  Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy. , 2003, The American journal of pathology.

[172]  C. Ardavı́n Origin, precursors and differentiation of mouse dendritic cells , 2003, Nature Reviews Immunology.

[173]  S. Zahler,et al.  An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. , 2003, The Journal of clinical investigation.

[174]  Li Wu,et al.  The Lymphoid Past of Mouse Plasmacytoid Cells and Thymic Dendritic Cells1 , 2003, The Journal of Immunology.

[175]  P. Rouleau,et al.  Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion 1 , 2003, The Journal of Immunology.

[176]  M. Ståhle-Bäckdahl,et al.  The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium. , 2003, The Journal of investigative dermatology.

[177]  Carl Nathan,et al.  Points of control in inflammation , 2002, Nature.

[178]  P. Libby Inflammation in atherosclerosis , 2002, Nature.

[179]  R. Schmidt,et al.  C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease. , 2002, The Journal of clinical investigation.

[180]  Kazuo Haze,et al.  Neutrophil Infiltration of Culprit Lesions in Acute Coronary Syndromes , 2002, Circulation.

[181]  J. Younger,et al.  Generation of C5a by phagocytic cells. , 2002, The American journal of pathology.

[182]  Ruediger C. Braun-Dullaeus,et al.  Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies , 2002, Nature Medicine.

[183]  R. Hancock,et al.  The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses1 , 2002, The Journal of Immunology.

[184]  H. Koyama,et al.  Fibrillar Collagen Regulation of Plasminogen Activator Inhibitor-1 Is Involved in Altered Smooth Muscle Cell Migration , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[185]  J. V. Sarma,et al.  Complement-Induced Impairment of Innate Immunity During Sepsis1 , 2002, The Journal of Immunology.

[186]  A. Dunn,et al.  Evaluation of role of G-CSF in the production, survival, and release of neutrophils from bone marrow into circulation. , 2002, Blood.

[187]  P. Nelson,et al.  The effect of endothelial cell overexpression of plasminogen activator inhibitor-1 on smooth muscle cell migration. , 2002, Journal of vascular surgery.

[188]  R. Bleackley,et al.  Cytotoxic T lymphocytes: all roads lead to death , 2002, Nature Reviews Immunology.

[189]  Y. Katsura Redefinition of lymphoid progenitors , 2002, Nature Reviews Immunology.

[190]  S. Marullo,et al.  Recruitment of Activated G Protein-coupled Receptors to Pre-existing Clathrin-coated Pits in Living Cells* , 2002, The Journal of Biological Chemistry.

[191]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[192]  Takaaki Ohtake,et al.  Innate antimicrobial peptide protects the skin from invasive bacterial infection , 2001, Nature.

[193]  G. Downey,et al.  Leukocyte elastase: physiological functions and role in acute lung injury. , 2001, American journal of respiratory and critical care medicine.

[194]  K. Ley,et al.  Adhesion molecules and atherogenesis. , 2001, Acta physiologica Scandinavica.

[195]  O. Chertov,et al.  Participation of mammalian defensins and cathelicidins in anti‐microbial immunity: receptors and activities of human defensins and cathelicidin (LL‐37) , 2001, Journal of leukocyte biology.

[196]  M. Walport Complement. First of two parts. , 2001, The New England journal of medicine.

[197]  K. Ley,et al.  RANTES Deposition by Platelets Triggers Monocyte Arrest on Inflamed and Atherosclerotic Endothelium , 2001, Circulation.

[198]  Christopher K. Glass,et al.  Atherosclerosis The Road Ahead , 2001, Cell.

[199]  C. Sorg,et al.  Transendothelial migration of 27E10+ human monocytes. , 2000, International immunology.

[200]  Ji Ming Wang,et al.  Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells , 2000, The Journal of experimental medicine.

[201]  O. Chertov,et al.  Leukocyte granule proteins mobilize innate host defenses and adaptive immune responses , 2000, Immunological reviews.

[202]  S. Shapiro,et al.  Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase. , 2000, Science.

[203]  M. Enomoto,et al.  A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells. , 2000, Molecular immunology.

[204]  S. Meri,et al.  Complement activation after oxidative stress: role of the lectin complement pathway. , 2000, The American journal of pathology.

[205]  H. Rus,et al.  Complement activation and atherosclerosis. , 1999, Molecular immunology.

[206]  P. Monk,et al.  Receptor activation by human C5a des Arg74 but not intact C5a is dependent on an interaction between Glu199 of the receptor and Lys68 of the ligand. , 1999, Biochemistry.

[207]  W. Gong,et al.  A Seven-transmembrane, G Protein–coupled Receptor, FPRL1, Mediates the Chemotactic Activity of Serum Amyloid A for Human Phagocytic Cells , 1999, The Journal of experimental medicine.

[208]  V. Fadok,et al.  CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3). , 1998, Journal of immunology.

[209]  John D Lambris,et al.  Complement diversity: a mechanism for generating immune diversity? , 1998, Immunology today.

[210]  Ronald McCarthy,et al.  Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis , 1998, Nature Medicine.

[211]  D. Klatzmann,et al.  Heterogeneity of mouse spleen dendritic cells: in vivo phagocytic activity, expression of macrophage markers, and subpopulation turnover. , 1998, Journal of immunology.

[212]  N. Borregaard Development of Neutrophil Granule Diversity , 1997, Annals of the New York Academy of Sciences.

[213]  Wiklund Ra,et al.  First of two parts , 1997 .

[214]  U. Höpken,et al.  Impaired Inflammatory Responses in the Reverse Arthus Reaction Through Genetic Deletion of the C5a Receptor , 1997, The Journal of experimental medicine.

[215]  C. Kozak,et al.  Identification of CRAMP, a Cathelin-related Antimicrobial Peptide Expressed in the Embryonic and Adult Mouse* , 1997, The Journal of Biological Chemistry.

[216]  G. Habicht,et al.  Immunity and the invertebrates. , 1996, Scientific American.

[217]  S. Wright,et al.  Human leukocyte elastase is an endogenous ligand for the integrin CR3 (CD11b/CD18, Mac-1, alpha M beta 2) and modulates polymorphonuclear leukocyte adhesion , 1996, The Journal of experimental medicine.

[218]  W. Nauseef,et al.  Isolation and Functional Analysis of Neutrophils , 1996, Current protocols in immunology.

[219]  C. Owen,et al.  Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases , 1995, The Journal of cell biology.

[220]  W D Wagner,et al.  A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. , 1995, Arteriosclerosis, thrombosis, and vascular biology.

[221]  W D Wagner,et al.  A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. , 1995, Circulation.

[222]  E. Topol,et al.  Cell adhesion molecules in coronary artery disease. , 1994, Journal of the American College of Cardiology.

[223]  N. Van Rooijen,et al.  Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. , 1994, Journal of immunological methods.

[224]  M. Oppermann,et al.  Plasma clearance of the human C5a anaphylatoxin by binding to leucocyte C5a receptors. , 1994, Immunology.

[225]  W D Wagner,et al.  A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

[226]  B. Lucchesi,et al.  The complement system in myocardial ischaemia/reperfusion injury. , 1994, Cardiovascular research.

[227]  S. Edwards Biochemistry and Physiology of the Neutrophil , 1994 .

[228]  J. Demartino,et al.  Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[229]  F. Boulay,et al.  Evidence that the extracellular N‐terminal domain of C5aR contains amino‐acid residues crucial for C5a binding , 1993, European journal of haematology.

[230]  M. Ferguson,et al.  Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis. , 1993, The Journal of clinical investigation.

[231]  L. Stanton,et al.  CD36 is a receptor for oxidized low density lipoprotein. , 1993, The Journal of biological chemistry.

[232]  R. Ross The pathogenesis of atherosclerosis: a perspective for the 1990s , 1993, Nature.

[233]  E. Rubin,et al.  Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells , 1992, Cell.

[234]  L. Kjeldsen,et al.  Subcellular localization and release of human neutrophil gelatinase, confirming the existence of separate gelatinase-containing granules. , 1992, The Biochemical journal.

[235]  N. Maeda,et al.  Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[236]  A. Denman Cellular and Molecular Immunology , 1992 .

[237]  W. Carter,et al.  B Lymphocyte Fibronectin Receptors: Expression and Utilization , 1991, Scandinavian journal of immunology.

[238]  I. Singer,et al.  Adhesomes: specific granules containing receptors for laminin, C3bi/fibrinogen, fibronectin, and vitronectin in human polymorphonuclear leukocytes and monocytes , 1989, The Journal of cell biology.

[239]  T. Carew,et al.  Initiation of atherosclerotic lesions in cholesterol-fed rabbits. II. Selective retention of LDL vs. selective increases in LDL permeability in susceptible sites of arteries. , 1989, Arteriosclerosis.

[240]  H. Perez,et al.  Chemotactic responses of human peripheral blood monocytes to the complement-derived peptides C5a and C5a des Arg. , 1985, Journal of immunology.

[241]  Gallin Ji Neutrophil specific granules: a fuse that ignites the inflammatory response. , 1984 .

[242]  R. Schreiber The chemistry and biology of complement receptors , 1984, Springer Seminars in Immunopathology.

[243]  R. Wiggins,et al.  Chemotactic activity generated from the fifth component of complement by plasma kallikrein of the rabbit , 1981, The Journal of experimental medicine.

[244]  L. Harker,et al.  Neutrophil kinetics in man. , 1976, The Journal of clinical investigation.

[245]  J. Kersey,et al.  T and B lymphocytes in humans. A review. , 1975, The American journal of pathology.

[246]  F. Rosen,et al.  Pathways to the complement system. , 1972, The New England journal of medicine.

[247]  H. Müller-Eberhard,et al.  Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase. , 1970, The Journal of clinical investigation.

[248]  George E. Cartwright,et al.  Analytical Review: The Kinetics of Granulopoiesis in Normal Man , 1964 .

[249]  M. Gadjeva,et al.  The Complement System , 2014, Methods in Molecular Biology.

[250]  S. Gorr Antimicrobial peptides in periodontal innate defense. , 2012, Frontiers of oral biology.

[251]  V. Schroeder,et al.  Das Komplementsystem , 2012, Hämostaseologie.

[252]  G. Maurer,et al.  Coronary late lumen loss of drug eluting stents is associated with increased serum levels of the complement components C3a and C5a. , 2010, Atherosclerosis.

[253]  Patrizia Agostinis,et al.  Immunogenic cell death, DAMPs and anticancer therapeutics: an emerging amalgamation. , 2010, Biochimica et biophysica acta.

[254]  C. Benjamim,et al.  Characterization of neutrophil extracellular traps in cats naturally infected with feline leukemia virus. , 2010, The Journal of general virology.

[255]  M. Frank,et al.  Therapeutic potential of complement modulation , 2010, Nature Reviews Drug Discovery.

[256]  Ping Yang,et al.  HMGB1, an innate alarmin, in the pathogenesis of type 1 diabetes. , 2009, International journal of clinical and experimental pathology.

[257]  A. Zychlinsky,et al.  Fungal and bacterial killing by neutrophils. , 2009, Methods in molecular biology.

[258]  S. Boudaly Activation of dendritic cells by polymorphonuclear neutrophils. , 2009, Frontiers in bioscience.

[259]  O. Soehnlein,et al.  ApoE(-/-)/lysozyme M(EGFP/EGFP) mice as a versatile model to study monocyte and neutrophil trafficking in atherosclerosis. , 2009, Atherosclerosis.

[260]  V. Witko-Sarsat,et al.  The role of neutrophils and monocytes in innate immunity. , 2008, Contributions to microbiology.

[261]  P. Gasque,et al.  Receptors for the anaphylatoxins C3a and C5a are expressed in human atherosclerotic coronary plaques. , 2007, Atherosclerosis.

[262]  G. de la Rosa,et al.  Alarmins initiate host defense. , 2007, Advances in experimental medicine and biology.

[263]  J. Ostojić,et al.  Fish cast NETs: neutrophil extracellular traps are released from fish neutrophils. , 2007, Developmental and comparative immunology.

[264]  A. Klos,et al.  C5L2--an anti-inflammatory molecule or a receptor for acylation stimulating protein (C3a-desArg)? , 2007, Advances in experimental medicine and biology.

[265]  I. Nagaoka,et al.  Human defensins and cathelicidins in the skin: beyond direct antimicrobial properties. , 2006, Critical reviews in immunology.

[266]  S Gordon,et al.  Macrophage receptors and immune recognition. , 2005, Annual review of immunology.

[267]  P. Ward,et al.  Role of C5a in inflammatory responses. , 2005, Annual review of immunology.

[268]  John Q. Davies,et al.  Isolation and culture of murine macrophages. , 2005, Methods in molecular biology.

[269]  H. Rus,et al.  The role of complement activation in atherosclerosis , 2004, Immunologic research.

[270]  F. Mollinedo Human neutrophil granules and exocytosis molecular control , 2022 .

[271]  S. Gordon Alternative activation of macrophages , 2003, Nature Reviews Immunology.

[272]  H. Itabe Oxidized low-density lipoproteins: what is understood and what remains to be clarified. , 2003, Biological & pharmaceutical bulletin.

[273]  C. Janeway,et al.  Innate immune recognition. , 2002, Annual review of immunology.

[274]  P. Carmeliet,et al.  PR39, a peptide regulator of angiogenesis , 2000, Nature Medicine.

[275]  S. Akira,et al.  Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. , 1999, Immunity.

[276]  C. Pepine The effects of angiotensin-converting enzyme inhibition on endothelial dysfunction: potential role in myocardial ischemia. , 1998, The American journal of cardiology.

[277]  P. Ehrlich Granules of the Human Neutrophilic Polymorphonuclear Leukocyte , 1997 .

[278]  C. Gerard,et al.  C5A anaphylatoxin and its seven transmembrane-segment receptor. , 1994, Annual review of immunology.

[279]  H. Rus,et al.  Quantitative determinations of immunoglobulins and complement components in human aortic atherosclerotic wall. , 1985, Medecine interne.

[280]  J. Gallin Neutrophil specific granules: a fuse that ignites the inflammatory response. , 1984, Clinical research.

[281]  M M WINTROBE,et al.  THE KINETICS OF GRANULOPOIESIS IN NORMAL MAN. , 1964, Blood.