Primary pulmonary hypertension, Castleman's disease and human herpesvirus‐8

Primary pulmonary hypertension (PPH) and Castleman's disease (CD) are rare conditions infrequently encountered in clinical practice. In this paper, two patients diagnosed with both of these diseases are reported. The authors speculate that rather than being a chance occurrence, these conditions are linked by a common angio-proliferative mechanism. Therefore, an association between infection with the human herpesvirus‐8 and the diseases of PPH and CD was sought. Evidence of human herpesvirus‐8 infection was found in the lung tissue and, specifically, in the plexiform lesions from one of the patients.

[1]  N. Voelkel,et al.  The pathobiology of pulmonary hypertension. Endothelium. , 2001, Clinics in chest medicine.

[2]  D. Resnick,et al.  Plasma Cell Dyscrasia with Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes: The POEMS Syndrome REPORT ON TWO CASES AND A REVIEW OF THE LITERATURE , 1980, Medicine.

[3]  P. Simmonds,et al.  Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen , 1996, The Lancet.

[4]  E. Cesarman,et al.  Polymerase chain reaction detection of Kaposi's sarcoma-associated herpesvirus-optimized protocols and their application to myeloma. , 2001, The Journal of molecular diagnostics : JMD.

[5]  J. Herrada,et al.  The Clinical Behavior of Localized and Multicentric Castleman Disease , 1998, Annals of Internal Medicine.

[6]  J. Shellito,et al.  Pulmonary Hypertension Associated With HIV Infection , 2001, Southern medical journal.

[7]  K. Kaibuchi,et al.  Elongation Factor-1α Is a Novel Substrate of Rho-Associated Kinase , 2000 .

[8]  N. Voelkel,et al.  Vascular Endothelial Growth Factor in Pulmonary Hypertension , 1996, Annals of the New York Academy of Sciences.

[9]  K. Kaibuchi,et al.  Elongation factor-1 alpha is a novel substrate of rho-associated kinase. , 2000, Biochemical and biophysical research communications.

[10]  S. Rich,et al.  Primary pulmonary hypertension: a vascular biology and translational research "Work in progress". , 2000, Circulation.

[11]  N. Voelkel,et al.  Primary pulmonary hypertension between inflammation and cancer. , 1998, Chest.

[12]  N. Voelkel,et al.  Microsatellite Instability of Endothelial Cell Growth and Apoptosis Genes Within Plexiform Lesions in Primary Pulmonary Hypertension , 2001, Circulation research.

[13]  Irene E. White,et al.  Quantitation of Cell-Free and Cell-Associated Kaposi's Sarcoma-Associated Herpesvirus DNA by Real-Time PCR , 2000, Journal of Clinical Microbiology.

[14]  P. Monini,et al.  Biology of Kaposi's sarcoma. , 2001, European journal of cancer.

[15]  G. Barbarini,et al.  Primary Pulmonary Hypertension in HIV Patients: A Systematic Review , 2001, Angiology.

[16]  A. Wald,et al.  Assessment of a Combined Testing Strategy for Detection of Antibodies to Human Herpesvirus 8 (HHV-8) in Persons with Kaposi's Sarcoma, Persons with Asymptomatic HHV-8 Infection, and Persons at Low Risk for HHV-8 Infection , 2002, Journal of Clinical Microbiology.

[17]  I. Maruyama,et al.  Increased Expression of Vascular Endothelial Growth Factor (VEGF) in Castleman's Disease: Proposed Pathomechanism of Vascular Proliferation in the Affected Lymph Node , 2000, Leukemia & lymphoma.

[18]  J. Dillner,et al.  Laboratory Diagnosis of Human Herpesvirus 8 Infection in Humans , 2002, European Journal of Clinical Microbiology and Infectious Diseases.

[19]  K. Shroyer,et al.  Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension. , 1998, The Journal of clinical investigation.

[20]  F. Authier,et al.  Pulmonary hypertension in POEMS syndrome: a new feature mediated by cytokines. , 1998, American journal of respiratory and critical care medicine.

[21]  M. Humbert,et al.  Imbalance between platelet vascular endothelial growth factor and platelet-derived growth factor in pulmonary hypertension. Effect of prostacyclin therapy. , 2000, American journal of respiratory and critical care medicine.

[22]  P. Gaulard,et al.  Human herpesvirus 8 infection in patients with POEMS syndrome-associated multicentric Castleman's disease. , 1999, Blood.

[23]  S. Winter,et al.  Elevated levels of tumor necrosis factor-beta, gamma-interferon, and IL-6 mRNA in Castleman's disease. , 1996, Medical and pediatric oncology.