Hemodynamic Evaluation of Basilar and Vertebral Artery Angioplasty

OBJECTIVE The postangioplasty evaluation of a stenotic vessel is often conducted by studying serial angiograms to determine the anatomic reduction in stenosis. In flow-limiting stenosis, the hemodynamic change that accompanies these anatomic changes is of great importance in evaluating the success of the angioplasty. The purpose of this article is to demonstrate the usefulness of phase contrast magnetic resonance angiography (PCMRA) in evaluating the hemodynamic changes that occur after angioplasty of the basilar and vertebral arteries. METHODS Between January 1998 and February 2000, PCMRA was performed for the hemodynamic evaluation of 130 patients who presented at our institution. Twenty-six patients were evaluated for vertebrobasilar insufficiency, and flow rates of their vertebral and basilar arteries were determined. In five patients, angioplasty was done on the basilar or vertebral arteries, and PCMRA was performed to determine flow rates before and after the procedure. RESULTS Of the five patients undergoing angioplasty, the average percentage of stenosis was 81%. The average increase in basilar artery flow rate was 46 ml/min (P < 0.05) after angioplasty. Two of these patients are described. One patient demonstrated the comparison of flow rates in the vertebral and basilar arteries after angioplasty. The second patient showed follow-up flow rates measured after angioplasty and up to 4 months later to predict restenosis. CONCLUSION The use of flow rate data before and after angioplasty is helpful not only to evaluate the treatment immediately after the procedure but also to evaluate the effectiveness of the treatment during a long period. PCMRA provides a noninvasive method for measuring arterial flow rates with far-reaching implications in neurosurgery.

[1]  M. P. Judkins,et al.  Transluminal Treatment of Arteriosclerotic Obstruction: Description of a New Technic and a Preliminary Report of Its Application , 1964, Circulation.

[2]  P. Purdy,et al.  The use of stents in the management of neurovascular disease: a review of historical and present status. , 2000, Neurosurgery.

[3]  M. Dake,et al.  Vertebral artery stenting following percutaneous transluminal angioplasty. Technical note. , 1996, Journal of neurosurgery.

[4]  C. Derouesné,et al.  Arterial occlusions in the vertebro-basilar system. A study of 44 patients with post-mortem data. , 1973, Brain : a journal of neurology.

[5]  B. Weksler,et al.  Anticoagulation in cerebral ischemia. , 1983, Stroke.

[6]  H. Bourquain,et al.  Cerebrovascular reserve before and after vertebral artery angioplasty. , 1999, AJNR. American journal of neuroradiology.

[7]  R. Adams,et al.  Occlusion of the basilar artery; a clinical and pathological study. , 1946, Brain : a journal of neurology.

[8]  R. Higashida,et al.  Transluminal angioplasty for atherosclerotic disease of the vertebral and basilar arteries. , 1993, Journal of neurosurgery.

[9]  T. Itakura,et al.  Percutaneous transluminal angioplasty for intracranial arteriosclerotic lesions , 1998, Neuroradiology.

[10]  N. Pelc,et al.  Blood flow in major cerebral arteries measured by phase-contrast cine MR. , 1994, AJNR. American journal of neuroradiology.

[11]  J. Ausman,et al.  Vertebrobasilar insufficiency. A review. , 1985, Archives of neurology.

[12]  R. Higashida,et al.  Intravascular stent and endovascular coil placement for a ruptured fusiform aneurysm of the basilar artery. Case report and review of the literature. , 1997, Journal of neurosurgery.

[13]  R. Edelman,et al.  Quantification of blood flow with dynamic MR imaging and presaturation bolus tracking. , 1989, Radiology.

[14]  N J Pelc,et al.  Arterial and venous blood flow: noninvasive quantitation with MR imaging. , 1992, Radiology.

[15]  P. Purdy,et al.  Percutaneous transluminal angioplasty and stenting of midbasilar stenoses: three technical case reports and literature review. , 1999, Neurosurgery.

[16]  D N Firmin,et al.  Blood flow imaging by cine magnetic resonance. , 1986, Journal of computer assisted tomography.

[17]  L. Guterman,et al.  Angioplasty for basilar artery atherosclerosis. Case report. , 1992, Journal of neurosurgery.

[18]  T. Sundt,et al.  Transluminal angioplasty for basilar artery stenosis. , 1980, Mayo Clinic proceedings.

[19]  G. Lanzino,et al.  Angioplasty and stenting of basilar artery stenosis: technical case report. , 1999, Neurosurgery.

[20]  M. Dujovny,et al.  Posterior circulation revascularization. , 1982, Clinical neurosurgery.

[21]  J. F. Herrick,et al.  The effect on the blood flow of decreasing the lumen of a blood vessel , 1938 .

[22]  A. Grüntzig TRANSLUMINAL DILATATION OF CORONARY-ARTERY STENOSIS , 1978, The Lancet.

[23]  C. Derdeyn,et al.  Reversal of Focal Misery Perfusion after Intracranial Angioplasty: Case Report , 2001, Neurosurgery.

[24]  W. Moore,et al.  Effect of flow rate and vessel calibre on critical arterial stenosis. , 1979, The Journal of surgical research.

[25]  B Hillen,et al.  Localizing role of hemodynamics in atherosclerosis in several human vertebrobasilar junction geometries. , 1998, Arteriosclerosis, thrombosis, and vascular biology.

[26]  M. Pessin,et al.  Posterior cerebral artery stenosis , 1987, Annals of neurology.

[27]  P. Gorelick,et al.  Basilar artery stenosis , 1987, Neurology.

[28]  N J Pelc,et al.  Magnetic Resonance Imaging of Blood Flow with a Phase Subtraction Technique: In Vitro and In Vivo Validation , 1993, Investigative radiology.

[29]  N J Pelc,et al.  Determination of cerebral blood flow with a phase-contrast cine MR imaging technique: evaluation of normal subjects and patients with arteriovenous malformations. , 1992, Radiology.

[30]  D. Firmin,et al.  Measurement of Flow with NMR Imaging Using a Gradient Pulse and Phase Difference Technique , 1984, Journal of computer assisted tomography.

[31]  R. Cohen,et al.  Microsurgical endarterectomy of the intracranial vertebral artery for vertebrobasilar transient ischemic attacks. , 1981, Neurosurgery.

[32]  N Alperin,et al.  Improved phase-contrast flow quantification by three-dimensional vessel localization. , 2000, Magnetic resonance imaging.

[33]  J. Easton What have we learned from recent antiplatelet trials? , 1998, Neurology.

[34]  R. Higashida,et al.  Tandem intracranial stent deployment for treatment of an iatrogenic, flow-limiting, basilar artery dissection: technical case report. , 1999, Neurosurgery.

[35]  G. Nesbit,et al.  Safety and efficacy of percutaneous transluminal angioplasty for intracranial atherosclerotic stenosis. , 1995, Stroke.

[36]  M O'Donnell,et al.  NMR blood flow imaging using multiecho, phase contrast sequences. , 1985, Medical physics.

[37]  J. Ausman,et al.  Anastomosis of occipital artery to anterior inferior cerebellar artery for vertebrobasilar junction stenosis. , 1981, Surgical neurology.

[38]  W. Mali,et al.  Effect of age on cerebral blood flow: measurement with ungated two-dimensional phase-contrast MR angiography in 250 adults. , 1998, Radiology.

[39]  George W. Williams,et al.  Basilar and distal vertebral artery stenosis: long-term follow-up. , 1986, Stroke.

[40]  Orchard Tj Letter: Mobile coronary care. , 1974 .

[41]  R. Higashida,et al.  Endovascular stenting of an acutely thrombosed basilar artery: technical case report and review of the literature. , 1999, Neurosurgery.

[42]  C. Fisher,et al.  Atherosclerosis of the Carotid and Vertebral Arteries—Extracranial and Intracranial , 1965 .

[43]  S. Ohta,et al.  Successful percutaneous transluminal angioplasty for basilar artery stenosis: technical case report. , 1996, Neurosurgery.

[44]  D. Krieger,et al.  Stent-assisted angioplasty of intracranial vertebrobasilar atherosclerosis: an initial experience. , 2000, Journal of neurosurgery.