Finite-element modeling of the hemodynamics of stented aneurysms.

BACKGROUND Computational fluid dynamics (CFD) simulations are used to analyze the wall shear stress distribution and flow streamlines near the throat of a stented basilar side-wall aneurysm. Previous studies of stented aneurysm flows used low mesh resolution, did not include mesh convergence analyses, and depended upon conformal meshing techniques that apply only to very artificial stent geometries. METHOD OF APPROACH We utilize general-purpose computer assisted design and unstructured mesh generation tools that apply in principle to stents and vasculature of arbitrary complexity. A mesh convergence analysis for stented steady flow is performed, varying node spacing near the stent. Physiologically realistic pulsatile simulations are then performed using the converged mesh. RESULTS Artifact-free resolution of the wall shear stress field on stent wires requires a node spacing of approximately 1/3 wire radius. Large-scale flow features tied to the velocity field are, however, captured at coarser resolution (nodes spaced by about one wire radius or more). CONCLUSIONS Results are consistent with previous work, but our methods yield more detailed insights into the complex flow dynamics. However, routine applications of CFD to anatomically realistic cases still depend upon further development of dedicated algorithms, most crucially to handle geometry definition and mesh generation for complicated stent deployments.

[1]  J. LaDisa,et al.  Three-Dimensional Computational Fluid Dynamics Modeling of Alterations in Coronary Wall Shear Stress Produced by Stent Implantation , 2003, Annals of Biomedical Engineering.

[2]  M. Gounis,et al.  The physics of endoluminal stenting in the treatment of cerebrovascular aneurysms , 2002, Neurological research.

[3]  D. Steinman,et al.  MESH RESOLUTION REQUIREMENTS FOR THE NUMERICAL SIMULATION OF FLOW THROUGH STENTED ANEURYSMS , 2002 .

[4]  J Laudan,et al.  Three-Dimensional Pulsatile Flow Simulation before and after Endovascular Coil Embolization of a Terminal Cerebral Aneurysm , 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[5]  Chee Kai Chua,et al.  Rapid Prototyping Applications in Medicine. Part 1: NURBS-Based Volume Modelling , 2001 .

[6]  C. R. Ethier,et al.  Requirements for mesh resolution in 3D computational hemodynamics. , 2001, Journal of biomechanical engineering.

[7]  C. Kerber,et al.  Analysis of slipstream flow in a wide-necked basilar artery aneurysm: evaluation of potential treatment regimens. , 2001, AJNR. American journal of neuroradiology.

[8]  C. R. Ethier,et al.  Steady flow separation patterns in a 45 degree junction , 2000, Journal of Fluid Mechanics.

[9]  J. Wardlaw,et al.  The detection and management of unruptured intracranial aneurysms. , 2000, Brain : a journal of neurology.

[10]  A. Wakhloo,et al.  Modeling of flow in a straight stented and nonstented side wall aneurysm model. , 1997, Journal of biomechanical engineering.

[11]  Einar M. Rønquist,et al.  An Operator-integration-factor splitting method for time-dependent problems: Application to incompressible fluid flow , 1990 .

[12]  Of references. , 1966, JAMA.