Model Cell Differentiation from a Human Cell Line Progenitor to Dendritic + Pathways in CD 34 Evidence for Distinct Intracellular Signaling

[1]  G.,et al.  Annexin V for Flow Cytometric Detection of Phosphatidylserine Expression on B Cells Undergoing Apoptosis , 2000 .

[2]  D. Harlan,et al.  Phorbol esters induce differentiation of human CD34+ hemopoietic progenitors to dendritic cells: evidence for protein kinase C-mediated signaling. , 1998, Journal of immunology.

[3]  R. Steinman,et al.  Dendritic cells and the control of immunity , 1998, Nature.

[4]  J. Jaffrezou,et al.  Restoration of TNF‐α‐induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P‐glycoprotein blocker PSC833 , 1998 .

[5]  C. Anasetti,et al.  Expression of CD86 on human marrow CD34(+) cells identifies immunocompetent committed precursors of macrophages and dendritic cells. , 1998, Blood.

[6]  N. Bhardwaj,et al.  A monocyte conditioned medium is more effective than defined cytokines in mediating the terminal maturation of human dendritic cells. , 1997, Blood.

[7]  D. Hart,et al.  Dendritic cells: unique leukocyte populations which control the primary immune response. , 1997, Blood.

[8]  B. Czerniecki,et al.  Calcium ionophore-treated peripheral blood monocytes and dendritic cells rapidly display characteristics of activated dendritic cells. , 1997, Journal of immunology.

[9]  G. Thomas,et al.  Nuclear localization of RelB is associated with effective antigen-presenting cell function. , 1997, Journal of immunology.

[10]  T. Mcclanahan,et al.  A dendritic-cell-derived C–C chemokine that preferentially attracts naive T cells , 1997, Nature.

[11]  B. Hock,et al.  Isolation of human blood dendritic cells using the CMRF-44 monoclonal antibody: implications for studies on antigen-presenting cell function and immunotherapy. , 1997, Blood.

[12]  K. Kliche,et al.  Use of leukemic dendritic cells for the generation of antileukemic cellular cytotoxicity against Philadelphia chromosome-positive chronic myelogenous leukemia. , 1997, Blood.

[13]  Francesca Granucci,et al.  Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures , 1997, The Journal of experimental medicine.

[14]  J. Banchereau,et al.  CD40 Ligation on Human Cord Blood CD34+Hematopoietic Progenitors Induces Their Proliferation and Differentiation into Functional Dendritic Cells , 1997, The Journal of experimental medicine.

[15]  C. Monks,et al.  Selective modulation of protein kinase C-Θ during T-cell activation , 1997, Nature.

[16]  R A Mufson,et al.  The role of serine/threonine phosphorylation in hematopoietic cytokine receptor signal transduction , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[17]  R. Testi,et al.  Ceramide Inhibits Antigen Uptake and Presentation by Dendritic Cells , 1996, The Journal of experimental medicine.

[18]  N. Olashaw Inducible activation of RelB in fibroblasts. , 1996, The Journal of biological chemistry.

[19]  I. Komuro,et al.  Generation of CD1+RelB+ dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes. , 1996, Blood.

[20]  M. Raphael,et al.  Differential nuclear localization of p50, p52, and RelB proteins in human accessory cells of the immune response in situ , 1996, European journal of immunology.

[21]  M. Record,et al.  Opposite effects of tumor necrosis factor alpha on the sphingomyelin-ceramide pathway in two myeloid leukemia cell lines: role of transverse sphingomyelin distribution in the plasma membrane. , 1996, Blood.

[22]  R. Steinman,et al.  Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post-colony-forming unit intermediate. , 1996, Blood.

[23]  M. Rosenzwajg,et al.  Human dendritic cell differentiation pathway from CD34+ hematopoietic precursor cells. , 1996, Blood.

[24]  C. Dunbar,et al.  Retroviral transduction of CD34-enriched hematopoietic progenitor cells under serum-free conditions. , 1996, Human gene therapy.

[25]  D. Fabbro,et al.  Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2. , 1995, European journal of biochemistry.

[26]  A. Galy,et al.  Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset. , 1995, Immunity.

[27]  C Danieli,et al.  Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products , 1995, The Journal of experimental medicine.

[28]  M. Moore,et al.  Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34+ bone marrow precursors cultured with c-kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-alpha. , 1995, Journal of immunology.

[29]  M. Kazanietz,et al.  Characterization of the cysteine-rich region of the Caenorhabditis elegans protein Unc-13 as a high affinity phorbol ester receptor. Analysis of ligand-binding interactions, lipid cofactor requirements, and inhibitor sensitivity. , 1995, The Journal of biological chemistry.

[30]  Liangji Zhou,et al.  Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. , 1995, Journal of immunology.

[31]  Y. Nishizuka Protein kinase C and lipid signaling for sustained cellular responses , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[32]  D. H. Robinson,et al.  Porcine brain microvascular endothelial cells support the in vitro expansion of human primitive hematopoietic bone marrow progenitor cells with a high replating potential: requirement for cell-to-cell interactions and colony-stimulating factors. , 1995, Blood.

[33]  D. Lo,et al.  Expression of relB is required for the development of thymic medulla and dendritic cells , 1995, Nature.

[34]  H. Schwarz,et al.  Dendritic cell progenitor is transformed by a conditional v-Rel estrogen receptor fusion protein v-ReIER , 1995, Cell.

[35]  F. Weih,et al.  Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family , 1995, Cell.

[36]  J. Banchereau,et al.  Characterization of human CD34+ derived dendritic/Langerhans cells (D-Lc). , 1995, Advances in experimental medicine and biology.

[37]  M. Krönke,et al.  The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin‐1 signal transduction , 1994, Journal of leukocyte biology.

[38]  B. Kistler,et al.  Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells. , 1994, The EMBO journal.

[39]  J. Bluestone,et al.  The B7 and CD28 receptor families. , 1994, Immunology today.

[40]  R. Steinman,et al.  Proliferating dendritic cell progenitors in human blood , 1994, The Journal of experimental medicine.

[41]  L. Manzel,et al.  Activation of beta-isozyme of protein kinase C (PKC beta) is necessary and sufficient for phorbol ester-induced differentiation of HL-60 promyelocytes. Studies with PKC beta-defective PET mutant. , 1994, The Journal of biological chemistry.

[42]  U. Sieben,et al.  STRUCTURE, REGULATION AND FUNCTION OF NF-1d3 , 1994 .

[43]  L. Davis,et al.  Comparative accessory cell function of human peripheral blood dendritic cells and monocytes. , 1993, Journal of immunology.

[44]  D. Carrasco,et al.  Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cells. , 1993, Development.

[45]  C. Monfries,et al.  A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin. , 1993, The Journal of biological chemistry.

[46]  R. Steinman,et al.  Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[47]  R. Steinman,et al.  Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor , 1992, The Journal of experimental medicine.

[48]  J. Banchereau,et al.  GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells , 1992, Nature.

[49]  S. Brenner,et al.  The Caenorhabditis elegans unc-13 gene product is a phospholipid-dependent high-affinity phorbol ester receptor. , 1992, The Biochemical journal.

[50]  J. Tikerpae,et al.  Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow. , 1992, Journal of immunology.

[51]  M. Mehlig,et al.  Dendritic cells from mouse bone marrow: in vitro differentiation using low doses of recombinant granulocyte-macrophage colony-stimulating factor. , 1992, Journal of immunological methods.

[52]  S. Carsons,et al.  TNF in combination with GM‐CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages , 1992, Journal of leukocyte biology.

[53]  S. Arruda,et al.  IL-4 receptor signal transduction in human monocytes is associated with protein kinase C translocation. , 1992, Journal of immunology.

[54]  P. Dobrzanski,et al.  RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B , 1992, Molecular and cellular biology.

[55]  M. Harnett,et al.  IL-4 promotes anti-Ig-mediated protein kinase C translocation and reverses phorbol ester-mediated protein kinase C down-regulation in murine B cells. , 1991, Journal of immunology.

[56]  C. Thompson,et al.  The genomic organization of the CD28 gene. Implications for the regulation of CD28 mRNA expression and heterogeneity. , 1990, Journal of immunology.

[57]  E. Engleman,et al.  Granulocyte-macrophage colony-stimulating factor promotes differentiation and survival of human peripheral blood dendritic cells in vitro. , 1990, The Journal of clinical investigation.

[58]  R. Callard,et al.  Interleukin 4 activates human B lymphocytes via transient inositol lipid hydrolysis and delayed cyclic adenosine monophosphate generation , 1990, European journal of immunology.

[59]  C. Thompson,et al.  T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression , 1987, Molecular and cellular biology.

[60]  H. Koeffler,et al.  Effects of phorbol ester on translocation and down-regulation of protein kinase C and phosphorylation of endogenous proteins in human acute myeloid leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a. , 1987, Cancer research.

[61]  R. Steinman,et al.  Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells , 1987, The Journal of experimental medicine.

[62]  H. Koeffler,et al.  Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a. , 1987, Cancer research.

[63]  M. Greaves,et al.  Divergent molecular phenotypes of KG1 and KG1a myeloid cell lines. , 1986, Blood.

[64]  H. Koeffler,et al.  Specific binding of [3H]phorbol dibutyrate to phorbol diester-responsive and -resistant clones of a human myeloid leukemia (KG-1) line 1. , 1983, Cancer research.

[65]  G. Rovera,et al.  Induction of differentiation of human myeloid leukemias: surface changes probed with monoclonal antibodies. , 1983, Blood.

[66]  H. Koeffler,et al.  Membrane differentiation in human myeloid cells: expression of unique profiles of cell surface glycoproteins in myeloid leukemic cell lines blocked at different stages of differentiation and maturation. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[67]  H. Koeffler,et al.  Phorbol ester effect on differentiation of human myeloid leukemia cell lines blocked at different stages of maturation. , 1981, Cancer research.

[68]  H. Koeffler,et al.  Induction by Phorbol Esters of Macrophage Differentiation in Human Leukaemia Cell Lines does not Require Cell Division , 1981, British journal of haematology.

[69]  H. Koeffler,et al.  An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1). , 1980, Blood.

[70]  H. Koeffler,et al.  Acute myelogenous leukemia: a human cell line responsive to colony-stimulating activity. , 1978, Science.