Heterotopic Ossification Revisited: A 21-Year Surgical Experience

Heterotopic ossification (HO) is an infrequently encountered complication of a burn. A retrospective review was undertaken to evaluate our treatment and results. Forty-two patients were identified with HO during 21 yrs. Mean age was 38 yrs. Mean total body surface area and third-degree burn were 55% and 37%, respectively. The elbow was the most frequent site (>90%), and 44% were bilateral. The next most common sites were shoulder, hip, knee, and forearm. Greater than 90% of patients had ventilator support and intensive care unit length of stay 58 and 79 days, respectively. HO was first suspected by decreased range of motion, painful and/or swollen joint, or a nerve deficit. Conventional radiographs were used to confirm the clinical diagnosis. The majority of burns overlying joints with HO were associated with prolonged wound closure because of depth, wound infection, or graft loss. Mean day of diagnosis was 71 days (range, 21–134). Excision of HO was undertaken only when range of motion compromised activities of daily living. Surgery successfully improved range of motion in all cases. The mean elbow arc of motion before and after surgery was 52 degrees and 119 degrees (range, 30–180 degrees), respectively. Seventy percent of elbows were ankylosed. A continuous passive motion device was instituted immediately postoperatively. Local postoperative complications included hematoma, wound dehiscence, infection, and nerve deficit. Maintaining range of motion was difficult for 75% of patients. Symptomatic recurrence of HO occurred in four elbows and one forearm. Because the cause(s) are unknown, prevention is impossible; once diagnosed, medical treatment is problematic and spontaneous resolution is infrequent. Surgery continues to be the recommended treatment when activities of daily living or life style are affected.

[1]  S. Patterson,et al.  Early excision of heterotopic bone in the forearm. , 2000, The Journal of hand surgery.

[2]  M. Ritter,et al.  Prophylactic indomethacin for the prevention of heterotopic bone formation following total hip arthroplasty. , 1985, Clinical orthopaedics and related research.

[3]  王满宜,et al.  Heterotopic ossification , 2004 .

[4]  A. Rico,et al.  Elbow anchylosis due to postburn heterotopic ossification. , 1996, The Journal of burn care & rehabilitation.

[5]  W. Healy,et al.  Heterotopic bone formation after hip surgery: prevention with single-dose postoperative hip irradiation. , 1988, Radiology.

[6]  J. Mountz,et al.  The predictive value of creatine phosphokinase and alkaline phosphatase in identification of heterotopic ossification in patients after spinal cord injury. , 2003, Archives of physical medicine and rehabilitation.

[7]  D. R. Fisher,et al.  Magnetic resonance imaging of myositis ossificans: analysis of seven cases , 2004, Skeletal Radiology.

[8]  V. Pellegrini,et al.  Preoperative Irradiation for Prevention of Heterotopic Ossification following Total Hip Arthroplasty* , 1996, The Journal of bone and joint surgery. American volume.

[9]  A. Chen,et al.  Surgical approaches for nonneurogenic elbow heterotopic ossification with ulnar neuropathy. , 2002, The Journal of trauma.

[10]  D. Zaleske,et al.  Heterotopic ossification around the elbow following burns in children: results after excision. , 2003, The Journal of bone and joint surgery. American volume.

[11]  L Dunn,et al.  A systematic survey of 13 randomized trials of non-steroidal anti-inflammatory drugs for the prevention of heterotopic bone formation after major hip surgery , 2000, Acta orthopaedica Scandinavica.

[12]  J. Ioannidis,et al.  Radiotherapy vs. nonsteroidal anti-inflammatory drugs for the prevention of heterotopic ossification after major hip procedures: a meta-analysis of randomized trials. , 2004, International journal of radiation oncology, biology, physics.

[13]  D. Garland Early excision of heterotopic ossification about the elbow followed by radiation therapy. , 1998, The Journal of bone and joint surgery. American volume.

[14]  D. Heimbach,et al.  Efficacy of continuous passive motion (CPM) devices with hand burns. , 1988, The Journal of burn care & rehabilitation.

[15]  H. Bruck,et al.  Radiographic changes in burns of the upper extremity. , 1972, Radiology.

[16]  S. S. Kristensen,et al.  The use of indomethacin to prevent the formation of heterotopic bone after total hip replacement. A randomized, double-blind clinical trial. , 1988, The Journal of bone and joint surgery. American volume.

[17]  G. Vanderstraeten,et al.  Heterotopic ossification: a review. , 2005, Journal of rehabilitation medicine.

[18]  K. Kiyomatsu,et al.  [Heterotopic bone formation]. , 1996, Ryoikibetsu shokogun shirizu.

[19]  E. Kirkman,et al.  Heterotopic calcification following burns: a prospective study. , 1972, The Journal of trauma.

[20]  Dia Shehab,et al.  Heterotopic ossification. , 2002, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[21]  G. Noël,et al.  [Prevention of heterotopic ossification about the hip: final results of two randomized trials in 410 patients using either preoperative or postoperative radiation therapy]. , 1998, Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique.

[22]  W. Peters Heterotopic ossification: can early surgery be performed, with a positive bone scan? , 1990, The Journal of burn care & rehabilitation.

[23]  P. Blachut,et al.  Range of motion and complications after postburn heterotopic bone excision about the elbow. , 1996, The Journal of trauma.

[24]  W. Mcmanus,et al.  Heterotopic bone formation in burned patients. , 1988, The Journal of trauma.

[25]  J. Hiebert,et al.  Postburn heterotopic ossification: insights for management decision making. , 1989, The Journal of trauma.

[26]  T. Rudd,et al.  Heterotopic bone formation: clinical, laboratory, and imaging correlation. , 1985, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[27]  J. Kolar,et al.  Periarticular soft-tissue changes as a late consequence of burns. , 1959, The Journal of bone and joint surgery. American volume.

[28]  L. Kinzl,et al.  Influence of etiology in heterotopic bone formation of the hip. , 2000, The Journal of trauma.

[29]  M. Hoffer,et al.  Excision of heterotopic ossification about elbows in patients with thermal injury. , 1978, The Journal of trauma.

[30]  M. Laere,et al.  Association between muscle trauma and heterotopic ossification in spinal cord injured patients: reflections on their causal relationship and the diagnostic value of ultrasonography , 1995, Paraplegia.

[31]  J. Galante,et al.  The efficacy of 500 CentiGray radiation in the prevention of heterotopic ossification after total hip arthroplasty: a prospective, randomized, pilot study. , 2003, The Journal of arthroplasty.

[32]  G. Germann,et al.  Manifestation of multifocal heterotopic ossifications with unusual locations as a complication after severe burn injury. , 1996, Burns : journal of the International Society for Burn Injuries.

[33]  S. L. Stover,et al.  Disodium etidronate in the prevention of postoperative recurrence of heterotopic ossification in spinal-cord injury patients. , 1976, The Journal of bone and joint surgery. American volume.

[34]  E. Evans,et al.  Bone and joint changes following burns; a roentgenographic study; preliminary report. , 1959, The Journal of bone and joint surgery. American volume.

[35]  C. Marn,et al.  Evaluation of ectopic bone by CT. , 1987, AJR. American journal of roentgenology.

[36]  M. Bosse,et al.  Heterotopic ossification as a complication of acetabular fracture. Prophylaxis with low-dose irradiation. , 1988, The Journal of bone and joint surgery. American volume.

[37]  J. T. Johnson Atypical myositis ossificans. , 1957, The Journal of bone and joint surgery. American volume.

[38]  R. Hotchkiss,et al.  Current therapy in the management of heterotopic ossification of the elbow: a review with case studies. , 1999, American journal of physical medicine & rehabilitation.

[39]  A. Richards,et al.  Heterotopic ossification after severe burns: a report of three cases and review of the literature. , 1997, Burns : journal of the International Society for Burn Injuries.

[40]  J. Neff,et al.  Heterotopic ossification: are range of motion exercises contraindicated? , 1986, The Journal of burn care & rehabilitation.

[41]  D. Jackson,et al.  BONE AND JOINT CHANGES FOLLOWING BURNS. , 1965, Clinical radiology.

[42]  E. Evans Orthopaedic measures in the treatment of severe burns. , 1966, The Journal of bone and joint surgery. American volume.

[43]  M. O'dell,et al.  Continuous passive motion in the management of heterotopic ossification in a brain injured patient. , 2001, American journal of physical medicine & rehabilitation.

[44]  J. Sylvester,et al.  The use of postoperative irradiation for the prevention of heterotopic bone formation after total hip replacement. , 1986, International journal of radiation oncology, biology, physics.