Decay of Maternally Derived Antibodies and Seroconversion to Respiratory Viral Infection in Pig Herds

This study investigated the decay of maternally derived antibodies to pseudorabies virus (PRV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine circovirus type 2 (PCV2) and swine influenza virus (SIV) in the pig herds in Taiwan. Additionally, the serological profiles of these viral pathogens were examined in a cross-sectional study of six pig populations. The observed half lives of maternally derived serum neutralization antibodies against PRV and PRRSV were 2.0 and 3.0 weeks, respectively. The estimated times to seronegativity to PRV and PRRSV were 12.2 and 10.4 weeks, respectively. At one week of age, over 80% of pigs were positive for PCV2 and hemagglutinin 1 (H1) SIV antibodies, but antibody decreased to undetectable levels at 11 and 5 weeks of age, respectively. Except for SIV infection, which probably exhibited sporadic, mild to moderate outbreaks, the most common sequence of seroconversion to the viral respiratory infections in the six pig herds appear to be in an order of PCV2, followed by PRRSV and PRV. The results of this study provide basic data needed to design effective vaccination programs and intervention strategies for controlling swine respiratory diseases.

[1]  J. Segalés,et al.  Sow porcine circovirus type 2 (PCV2) status effect on litter mortality in postweaning multisystemic wasting syndrome (PMWS). , 2007, Research in veterinary science.

[2]  J. Segalés,et al.  Detection of porcine reproductive and respiratory syndrome virus, porcine circovirus type 2, swine influenza virus and Aujeszky's disease virus in cases of porcine proliferative and necrotizing pneumonia (PNP) in Spain. , 2007, Veterinary microbiology.

[3]  E. Thacker.  Lung inflammatory responses. , 2006, Veterinary research.

[4]  G. Appleyard,et al.  Detection of Porcine circovirus type 2 viremia and seroconversion in naturally infected pigs in a farrow-to-finish barn. , 2006, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.

[5]  S. Yu,et al.  Experimental Reproduction of Postweaning Multisystemic Wasting Syndrome in Pigs by Dual Infection with Mycoplasma hyopneumoniae and Porcine Circovirus Type 2 , 2004, Veterinary pathology.

[6]  Ji Man Kim,et al.  Association of porcine circovirus 2 with porcine respiratory disease complex. , 2003, Veterinary journal.

[7]  M. Pan,et al.  New H1N2 and H3N1 influenza viruses in Taiwanese pig herds. , 2003, The Veterinary record.

[8]  S. Goyal,et al.  Retrospective analysis of etiologic agents associated with respiratory diseases in pigs. , 2003, The Canadian veterinary journal = La revue veterinaire canadienne.

[9]  R. Larochelle,et al.  Comparative serologic and virologic study of commercial swine herds with and without postweaning multisystemic wasting syndrome. , 2003, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.

[10]  F. Osorio,et al.  Gradual development of the interferon-gamma response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination. , 2003, Virology.

[11]  P. Heinen,et al.  Estimating the incidence of influenza-virus infections in Dutch weaned piglets using blood samples from a cross-sectional study. , 2003, Veterinary microbiology.

[12]  P. Halbur,et al.  Experimental Reproduction of Severe Disease in CD/CD Pigs Concurrently Infected with Type 2 Porcine Circovirus and Porcine Reproductive and Respiratory Syndrome Virus , 2001, Veterinary pathology.

[13]  K. Stärk.  Epidemiological investigation of the influence of environmental risk factors on respiratory diseases in swine--a literature review. , 2000, Veterinary journal.

[14]  P. Yang,et al.  Persistence of porcine reproductive and respiratory syndrome virus in intensive farrow-to-finish pig herds. , 1997, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.

[15]  C. Choi,et al.  Immunity to PRRSV: Double-edged sword , 1997, Veterinary Microbiology.

[16]  J. Harding.  Post-weaning multisystemic wasting syndrome (PMWS): preliminary epidemiology and clinical presentation. , 1997 .

[17]  R. Kitching,et al.  The interference by maternally-derived antibody with active immunization of farm animals against foot-and-mouth disease , 1995, British Veterinary Journal.

[18]  M. Pensaert,et al.  Pattern of infection with the porcine reproductive and respiratory syndrome virus on swine farms in Belgium. , 1995, Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B.

[19]  E. Ryu.  Aujeszky's disease pseudorabies , 1975 .