Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
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Liu Liu | Hacer Karatas | Liu Liu | M. Lei | D. Bernard | Shaomeng Wang | Haibin Zhou | Haibin Zhou | Ming Lei | Denzil Bernard | Shaomeng Wang | Jing Huang | Hacer Karatas | Alexandro Navarro | Jing Huang | Alexandro Navarro
[1] Thomas A Milne,et al. Interaction of MLL amino terminal sequences with menin is required for transformation. , 2005, Cancer research.
[2] É. Marsault,et al. Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery. , 2011, Journal of medicinal chemistry.
[3] Maksymilian Chruszcz,et al. Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. , 2012, Blood.
[4] M. Krzywinski,et al. New insights to the MLL recombinome of acute leukemias , 2009, Leukemia.
[5] Shaomeng Wang,et al. Analysis of Flexibility and Hotspots in Bcl-xL and Mcl-1 Proteins for the Design of Selective Small-Molecule Inhibitors. , 2012, ACS medicinal chemistry letters.
[6] Jolanta Grembecka,et al. Molecular Basis of the Mixed Lineage Leukemia-Menin Interaction , 2010, The Journal of Biological Chemistry.
[7] Xueliang Fang,et al. Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization. , 2004, Analytical biochemistry.
[8] Ya-Xiong Chen,et al. The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[9] Shaomeng Wang,et al. Hydrophobic Binding Hot Spots of Bcl-xL Protein-Protein Interfaces by Cosolvent Molecular Dynamics Simulation. , 2011, ACS medicinal chemistry letters.
[10] Shaomeng Wang,et al. Computational analysis of protein hotspots. , 2010, ACS medicinal chemistry letters.
[11] P. Kollman,et al. How well does a restrained electrostatic potential (RESP) model perform in calculating conformational energies of organic and biological molecules? , 2000 .
[12] Matthew Meyerson,et al. The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis , 2005, Cell.
[13] Helen E Blackwell,et al. Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis. , 1998, Angewandte Chemie.
[14] Scott A. Armstrong,et al. MLL translocations, histone modifications and leukaemia stem-cell development , 2007, Nature Reviews Cancer.
[15] Jolanta Grembecka,et al. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. , 2012, Nature chemical biology.
[16] Stephen P. Hale,et al. The exploration of macrocycles for drug discovery — an underexploited structural class , 2008, Nature Reviews Drug Discovery.
[17] T. Rabbitts,et al. Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis. , 2004, Genes & development.
[18] M. Lei,et al. The same pocket in menin binds both MLL and JUND but has opposite effects on transcription , 2012, Nature.