Proof of principle: quality control of therapeutic cell preparations using senescence-associated DNA-methylation changes

[1]  W. Wagner,et al.  Proof of principle: quality control of therapeutic cell preparations using senescence-associated DNA-methylation changes , 2014, BMC Research Notes.

[2]  A. Chambery,et al.  Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells , 2013, Cell Death and Disease.

[3]  Andrew E. Teschendorff,et al.  Age-associated epigenetic drift: implications, and a case of epigenetic thrift? , 2013, Human molecular genetics.

[4]  William Wijns,et al.  Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics. , 2013, Journal of the American College of Cardiology.

[5]  T. Brümmendorf,et al.  Pluripotent stem cells escape from senescence-associated DNA methylation changes , 2013, Genome research.

[6]  W. Wagner,et al.  Epigenetic biomarker to determine replicative senescence of cultured cells. , 2013, Methods in molecular biology.

[7]  M. Rosemann,et al.  Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells , 2013, Cellular and Molecular Life Sciences.

[8]  M. Miloso,et al.  From cytogenomic to epigenomic profiles: monitoring the biologic behavior of in vitro cultured human bone marrow mesenchymal stem cells , 2012, Stem Cell Research & Therapy.

[9]  M. Zenke,et al.  Monitoring of cellular senescence by DNA‐methylation at specific CpG sites , 2012, Aging cell.

[10]  A. Ho,et al.  Population dynamics of mesenchymal stromal cells during culture expansion. , 2012, Cytotherapy.

[11]  W. Tsai,et al.  Decreased proliferation of aging tenocytes is associated with down‐regulation of cellular senescence‐inhibited gene and up‐regulation of p27 , 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[12]  Wolfgang Wagner,et al.  Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks , 2011, Aging.

[13]  G. Lepperdinger Inflammation and mesenchymal stem cell aging , 2011, Current opinion in immunology.

[14]  Wolfgang Wagner,et al.  Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions , 2010, Haematologica.

[15]  Carmen Koch,et al.  How to track cellular aging of mesenchymal stromal cells? , 2010, Aging.

[16]  Hélène Rouard,et al.  Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation. , 2010, Blood.

[17]  B. Korn,et al.  DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells , 2010, Aging cell.

[18]  F. D. D. Fagagna,et al.  SASPense and DDRama in cancer and ageing , 2009, Nature Cell Biology.

[19]  Regina Brunauer,et al.  Controversial issue: Is it safe to employ mesenchymal stem cells in cell-based therapies? , 2008, Experimental Gerontology.

[20]  V. Beneš,et al.  Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process , 2008, PloS one.

[21]  J. Campisi,et al.  Cellular senescence: when bad things happen to good cells , 2007, Nature Reviews Molecular Cell Biology.

[22]  R. Brunauer,et al.  Techniques in gerontology: Cell lines as standards for telomere length and telomerase activity assessment , 2006, Experimental Gerontology.

[23]  Ardeshir Ghavamzadeh,et al.  BMC Cell Biology BioMed Central Research article Aging of mesenchymal stem cell in vitro , 2005 .

[24]  I. Bellantuono,et al.  Study of Telomere Length Reveals Rapid Aging of Human Marrow Stromal Cells following In Vitro Expansion , 2004, Stem cells.

[25]  Qin M. Chen,et al.  Subcytotoxic H2O2 Stress Triggers a Release of Transforming Growth Factor-β1, Which Induces Biomarkers of Cellular Senescence of Human Diploid Fibroblasts* , 2001, The Journal of Biological Chemistry.

[26]  M. Mastrogiacomo,et al.  Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy. , 2000, Experimental hematology.

[27]  C Roskelley,et al.  A biomarker that identifies senescent human cells in culture and in aging skin in vivo. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[28]  C B Harley,et al.  Telomere length predicts replicative capacity of human fibroblasts. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[29]  L. Hayflick,et al.  The serial cultivation of human diploid cell strains. , 1961, Experimental cell research.