Ultra-flexible and brain-conformable micro-electrocorticography device with low impedance PEDOT-carbon nanotube coated microelectrodes

Electrocorticography, thanks to its low degree of invasiveness, has received in recent years an increasing attention for chronic brain-machine interface applications. To be up to the task, electrocorticography electrode arrays can benefit from several improvements. Better recording abilities can be obtained through smaller, low impedance and high density electrodes, while conformability can provide superior adhesion to the cortex surface and lower biological impact. In this work we present an ultra-flexible and brain-conformable polyimide-based micro-ECoG array with low-impedance poly(3,4-ethylenedioxythiophene) (PEDOT)-carbon nanotube coated microelectrodes. A first in vivo validation of our device is performed on rat somatosensory cortex.

[1]  P ? ? ? ? ? ? ? % ? ? ? ? , 1991 .

[2]  Charles M. Lieber,et al.  Nanomaterials for Neural Interfaces , 2009 .

[3]  David C. Martin,et al.  Chronic neural recordings using silicon microelectrode arrays electrochemically deposited with a poly(3,4-ethylenedioxythiophene) (PEDOT) film , 2006, Journal of neural engineering.

[4]  John B. Shoven,et al.  I , Edinburgh Medical and Surgical Journal.

[5]  A. S. Spinelli,et al.  A power-efficient analog integrated circuit for amplification and detection of neural signals , 2008, 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[6]  Brian Litt,et al.  Proceedings of the Second International Workshop on Advances in Electrocorticography , 2011, Epilepsy & Behavior.

[7]  David T. Bundy,et al.  Microscale recording from human motor cortex: implications for minimally invasive electrocorticographic brain-computer interfaces. , 2009, Neurosurgical focus.

[8]  Bradley Greger,et al.  Human neocortical electrical activity recorded on nonpenetrating microwire arrays: applicability for neuroprostheses. , 2009, Neurosurgical focus.

[9]  Ehsan Arabzadeh,et al.  Correlated physiological and perceptual effects of noise in a tactile stimulus , 2010, Proceedings of the National Academy of Sciences.

[10]  R. Oostenveld,et al.  A MEMS-based flexible multichannel ECoG-electrode array , 2009, Journal of neural engineering.

[11]  P. Cochat,et al.  Et al , 2008, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.

[12]  Mohammad Reza Abidian,et al.  Multifunctional Nanobiomaterials for Neural Interfaces , 2009 .

[13]  Justin C. Williams,et al.  A Micro-Electrocorticography Platform and Deployment Strategies for Chronic BCI Applications , 2011, Clinical EEG and neuroscience.

[14]  J. Fawcett,et al.  Assessment of the biocompatibility of photosensitive polyimide for implantable medical device use. , 2009, Journal of biomedical materials research. Part A.

[15]  Robert Oostenveld,et al.  Proceedings of the First International Workshop on Advances in Electrocorticography , 2010, Epilepsy & Behavior.

[16]  Brian Litt,et al.  Proceedings of the Third International Workshop on Advances in Electrocorticography , 2010, Epilepsy & Behavior.

[17]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[18]  P. Leleux,et al.  Highly Conformable Conducting Polymer Electrodes for In Vivo Recordings , 2011, Advanced materials.

[20]  Luciano Fadiga,et al.  Biologically compatible neural interface to safely couple nanocoated electrodes to the surface of the brain. , 2013, ACS nano.

[21]  Luca Maiolo,et al.  Low-temperature polysilicon thin film transistors on polyimide substrates for electronics on plastic , 2008 .

[22]  Luciano Fadiga,et al.  A low-power integrated circuit for analog spike detection and sorting in neural prosthesis systems , 2008, 2008 IEEE Biomedical Circuits and Systems Conference.

[23]  M. Stelzle,et al.  PEDOT–CNT Composite Microelectrodes for Recording and Electrostimulation Applications: Fabrication, Morphology, and Electrical Properties , 2012, Front. Neuroeng..

[24]  B. A. Hollenberg,et al.  A MEMS fabricated flexible electrode array for recording surface field potentials , 2006, Journal of Neuroscience Methods.