Safety and efficacy of intravenous thrombolysis in stroke patients on prior antiplatelet therapy in the WAKE-UP trial

C. Gerloff | T. Neumann-Haefelin | M. Endres | M. Hennerici | C. Hobohm | A. Leger | Y. Samson | E. Warburton | T. Truelsen | F. Fazekas | D. Calvet | P. Nederkoorn | S. Crozier | C. Oppenheim | J. Arenillas | P. Tyrell | S. Pedraza | L. Ostergaard | U. Ziemann | F. Heinen | R. Ganeshan | C. Rosso | P. Eisele | P. Amarenco | C. Opherk | F. Buggle | I. Ford | V. Thijs | N. Nighoghossian | M. Wolf | K. Muir | O. Singer | J. Hoppe | A. Lauer | J. Fiebach | C. Majoie | D. Hemelsoet | J. Puig | J. Röther | E. López‐Cancio | M. Gomis | L. Dorado | N. P. de la Ossa | V. Guiraud | B. Hanseeuw | T. Moulin | B. Cheng | G. Thomalla | R. Dziewas | N. Morel | F. Moreton | E. Jüttler | I. Sibon | S. Rosenbaum | M. Ebinger | M. Rozanski | R. Brouns | T. Krause | S. Stösser | E. Touzé | S. Nagel | R. Perry | A. Alonso | M. Griebe | Robbert-Jan van Hooff | A. De Smedt | A. Gaenslen | F. Wollenweber | J. Fiehler | C. Gumbinger | P. Ringleb | M. Seidel | M. Zuber | Verena Panitz | J. Minnerup | C. Kleinschnitz | C. Weimar | Lucie A van den Berg | W. Schonewille | J. Purrucker | A. Mueller | Y. Vandermeeren | T. Magnus | D. Michalski | C. Hametner | K. Häusler | R. Fleischmann | Julian Schröder | O. Menn | C. Hoyer | A. Peeters | J. Marstrand | N. Hjort | M. Lorenz | A. Harloff | N. Sprigg | B. Modrau | P. Laloux | P. Desfontaines | A. Viguier | C. Simonsen | F. Boutitie | B. Cheripelli | Tae-Hee Cho | I. Galinovic | A. Golsari | P. Roy | Anke Wouters | R. Lemmens | L. Ispierto | B. Swinnen | T. Bobinger | C. Mellerio | G. Turc | S. Schwarting | R. Veltkamp | H. Iversen | T. Harbo | W. Pfeilschifter | V. Puetz | B. Kallmünzer | C. Lamy | L. Derex | M. Ebner | S. Poli | T. Kessler | G. Cloud | A. Schwarz | S. Deltour | I. Smets | M. Klein | P. Kraft | J. Lückl | C. Choe | M. Yger | L. Bonnet | Mareva Ciatipis | A. Machet | C. Roffe | B. Bouamra | J. Demeestere | G. Weise | S. Mundiyanapurath | P. Renou | A. Møller | L. Breuer | A. Dixit | Julia Meier | P. Mulero | E. Cortijo | D. Bindila | V. Wolff | A. Alegiani | K. Vestergaard | P. Meden | A. Pichler | R. Dittrich | Ignaz Gunreben | J. Tembl | Anthony C. Pereira | M. Ritter | O. Geraghty | S. Cakmak | J. Mutzenbach | A. Bayer-Karpinska | Craig J. Smith | S. Godon-Hardy | H. Neugebauer | Kosmas Macha | S. Gerner | J. Appleton | H. Christensen | Francesca Russo | E. Palomeras | Cecile van Eendenburg | S. Felix | Hans-Werner Pledl | C. Foerch | P. Vanacker | P. Vanderdonckt | R. Geran | M. Almendrote | G. Lucente | D. Vilas | L. Kellert | J. Becerra | K. Dani | N. Raposo | A. Calleja | M. Rodríguez‐Yáñez | M. Hernández | M. Rutgers | C. Lovelock | T. Gattringer | L. Legrand | Lillian Choy | N. Kurka | A. Seiler | T. Zonneveld | P. Bourgeois | R. Kollmar | R. Bathe-Peters | S. Moeller | D. Kalladka | E. Vancaester | J. Sembill | D. Madžar | J. Bardutzky | Xuya Huang | D. Broughton | B. Moynihan | T. Sauer | M. Jiménez | V. Žegarac | T. Reiff | H. Amiri | C. Esperón | C. Beck | D. Damgaard | M. Poulsen | F. Baronnet-Chauvet | J. Birchenall | E. Bodiguel | V. Domigo | Ludovic Morin | N. Berhoune | T. Ritzenthaler | A. Bonnet | J. Cogez | S. Schieber | M. Koehrmann | K. Filipski | N. de Klippel | J. Weber | Boris Raul Acosta | K. Aegidius | C. Albiker | K. Althaus | B. Anders | A. Aniculaesei | C. Bähr | Olga Belchí Guillamon | A. Benoit | K. Blanc-Lasserre | M. Gonzales | U. Bodechtel | Urszula Bojaryn | L. Breynaert | S. Brugirard | B. Bruneel | David Carrera | Hsin-Chieh Chen | L. Dobbels | C. Druart | K. H. Dupont | A. Dusart | Myriam Edjali-Goujon | A. Elhfnawy | Ana Etexberria | N. Evans | S. Fandler | A. Filipov | Elena Meseguer Gancedo | A. Garrido | Jos Göhler | D. Górriz | V. Gramse | L. Grau | C. Guerrero | Damla Guerzoglu | S. Guettier | F. Haertig | Andreas Hansen | Jakob Hansen | P. Harmel | V. Held | S. Hellwig | J. Herm | S. Hermans | J. Vicente | Cristina Hobeanu | E. Höfner | K. Hohenbichler | Eva Hornberger | N. Ipsen | I. Isern | L. L. Jeppesen | Jan Jungehülsing | Arindam Kar | U. Khan | Matti Klockziem | Michael Knops | L. Koehler | Heinz Kohlfürst | B. Kristensen | Jan M. Kröber | A. Ladoux | E. Landrault | C. Lebely | Jonathan Leempoel | Lin Li | Anna-Mareike Löbbe | F. London | S. Louw | M. Sánchez | Alain Luna | Daniel Mackenrodt | A. Männer | V. Maqueda | Alicia Martinez | A. Marzina | Laura Mechthouff | G. Meersman | N. Meyer | P. Michels | L. Michelsen | Mónica Millán Torné | O. Naggara | Arumugam Nallasivan | I. Navalpotro | A. Nave | S. Oberndorfer | L. Oppel | Johannes Orthgiess | P. Paindeville | B. Patel | D. Peeters | A. Pellisé | J. Pelz | S. Peysson | A. Pierskalla | Katrin Pomrehn | L. Prats | Silvia Presas | E. Prohaska | Josep Puig Alcántara | V. Quenardelle | Sankaranarayanan Ramachandran | Soulliard Raphaelle | M. Remmers | Martin Ribitsch | H. Richter | G. Rodier | C. Rodriguez-Régent | M. Roennefarth | S. Sagnier | Josep Sánchez | J. Schäfer | J. Schill | D. Schlak | L. Schlemm | Sein Schmidt | A. Schulz | J. Schurig | C. Schwarzbach | Joaquín Serena Leal | Ashita Shetty | Aravinth Sivagnanaratham | P. Soors | Maximilian Spruegel | David Stark | S. Steinert | Markus Stuermlinger | R. Tamazyan | Mikel Terceno Izaga | G. Turine | S. Tütüncü | X. Ustrell | W. Vadot | A. Vallet | Pauline Vallet | F. Vanhee | Dieke Voget | Claudia E. Weber | Mirko Wegscheider | Karin Weinstich | C. Weise | Christiaan Willems | K. Winder | M. Wittayer | M. Wolf | Christian Wollboldt | B. Yalo | N. Younan | L. Yperzeele | P. Zeiner | Alina Königsberg | B. Frey | Sophie A. van den Berg | Götz Christian Amir Anna Bastian Christoph Chi-un Dieke Thomalla Gerloff Golsari Alegiani Cheng Beck | Isabelle van Sloten | Noelia Ruiz de Morales | Paul von Weitzel | Christina Back | J. DeKeyser | Beatrijs De Coene | C. De Maeseneire | Isabel de Hollander | S. el Tawil | S. Gutiérrez | Maria del Mar Castellanos Rodrigo | Jörg von Schrader | T. Neumann‐Haefelin | Bart Swinnen | K. Blanc‐Lasserre | Serdar Tütüncü | M. Rodríguez-Yáñez | Katharina Filipski | María Hernández | Ivana Galinovic | Robin Lemmens | A. Luna | P. Vallet | Sophie A van den Berg | A. Wouters | D. Gorriz

[1]  Francis Deng.  Heidelberg Bleeding Classification , 2021, Radiopaedia.org.

[2]  A. Alexandrov,et al.  Safety and efficacy of dual antiplatelet pretreatment in patients with ischemic stroke treated with IV thrombolysis , 2020, Neurology.

[3]  A. Alexandrov,et al.  Safety and efficacy of dual antiplatelet pretreatment in ischemic stroke patients treated with IV thrombolysis: A systematic review and meta-analysis. , 2020, Neurology.

[4]  Correction to: Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. , 2019, Stroke.

[5]  W. Powers,et al.  Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. , 2019, Stroke.

[6]  M. Hill,et al.  Current practice and future directions in the diagnosis and acute treatment of ischaemic stroke , 2018, The Lancet.

[7]  C. Gerloff,et al.  MRI‐Guided Thrombolysis for Stroke with Unknown Time of Onset , 2018, The New England journal of medicine.

[8]  S. Tomašević-Todorović,et al.  The Impact of Comorbidity on Rehabilitation Outcome After Ischemic Stroke , 2018, Acta clinica Croatica.

[9]  A. Alexandrov,et al.  Antiplatelet pretreatment and outcomes in intravenous thrombolysis for stroke: a systematic review and meta-analysis , 2017, Journal of Neurology.

[10]  M. Woodward,et al.  Low- Versus Standard-Dose Alteplase in Patients on Prior Antiplatelet Therapy: The ENCHANTED Trial (Enhanced Control of Hypertension and Thrombolysis Stroke Study) , 2017, Stroke.

[11]  J. Tao,et al.  Intravenous Thrombolysis for Acute Ischemic Stroke in Patients Receiving Antiplatelet Therapy: A Systematic Review and Meta‐analysis of 19 Studies , 2016, Journal of the American Heart Association.

[12]  P. Gorelick,et al.  Comparative Effectiveness of Prestroke Aspirin on Stroke Severity and Outcome , 2016, Annals of neurology.

[13]  Eric E. Smith,et al.  Risks and Benefits Associated With Prestroke Antiplatelet Therapy Among Patients With Acute Ischemic Stroke Treated With Intravenous Tissue Plasminogen Activator. , 2016, JAMA neurology.

[14]  A. Demchuk,et al.  The Heidelberg Bleeding Classification: Classification of Bleeding Events After Ischemic Stroke and Reperfusion Therapy. , 2015, Stroke.

[15]  H. Kamal,et al.  Safety of Intravenous Thrombolysis for Acute Ischemic Stroke in Patients with Preexisting Intracranial Neoplasms: A Case Series , 2015, International journal of stroke : official journal of the International Stroke Society.

[16]  D. Zheng,et al.  Prior Antiplatelet Agent Use and Outcomes after Intravenous Thrombolysis with Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke: A Meta-Analysis of Cohort Studies and Randomized Controlled Trials , 2015, International journal of stroke : official journal of the International Stroke Society.

[17]  Peter Sandercock,et al.  Risk Factors for Intracranial Hemorrhage in Acute Ischemic Stroke Patients Treated With Recombinant Tissue Plasminogen Activator: A Systematic Review and Meta-Analysis of 55 Studies , 2012, Stroke.

[18]  Yvo B Roos,et al.  Early administration of aspirin in patients treated with alteplase for acute ischaemic stroke: a randomised controlled trial , 2012, The Lancet.

[19]  Gary A. Ford,et al.  Predicting the Risk of Symptomatic Intracerebral Hemorrhage in Ischemic Stroke Treated With Intravenous Alteplase: Safe Implementation of Treatments in Stroke (SITS) Symptomatic Intracerebral Hemorrhage Risk Score , 2012, Stroke.

[20]  Ivana Galinovic,et al.  DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational study , 2011, The Lancet Neurology.

[21]  L. Soinne,et al.  Safety of Intravenous Thrombolysis for Acute Ischemic Stroke in Patients Receiving Antiplatelet Therapy at Stroke Onset , 2010, Stroke.

[22]  A. Hakim,et al.  Pre Admission Antithrombotics are Associated with Improved Outcomes following Ischaemic Stroke: A Cohort from the Registry of the Canadian Stroke Network , 2009, International journal of stroke : official journal of the International Stroke Society.

[23]  J. Geddes,et al.  What is a randomised controlled trial? , 2009, Epidemiologia e Psichiatria Sociale.

[24]  P. Schellinger,et al.  Two Tales: Hemorrhagic Transformation but Not Parenchymal Hemorrhage After Thrombolysis Is Related to Severity and Duration of Ischemia: MRI Study of Acute Stroke Patients Treated With Intravenous Tissue Plasminogen Activator Within 6 Hours , 2007, Stroke.

[25]  David B Matchar,et al.  Charlson Index Comorbidity Adjustment for Ischemic Stroke Outcome Studies , 2004, Stroke.

[26]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..

[27]  G. L. Paul.  Outcome studies. , 1991, Hospital & community psychiatry.