论文信息 - Synthesis of N-Protected o-Hydroxyl-phenyl—α-Aminophosphonic Monoester

Synthesis of N-Protected o-Hydroxyl-phenyl—α-Aminophosphonic Monoester

A series of N-protected O-hydroxylphenyl α-aminophosphonic monoesters were synthesized via three-component Mannich-type reactions of phosphoramides, aldehydes (ketones) and 2-chlorobenzo [1,3,2] dioxaphospholes under solvent free and catalyst-free conditions, followed by hydrolysis. It is an efficient and green method to the synthesis of N-phosphoramino O-hydroxyphenyl 1-aminoalkylphosphonic monoesters with high yields.

Jianfeng Zhang | Zhiwei Miao | Ruyu Chen | Zhanwei Cui

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