A small molecule activator of AKT does not reduce ischemic injury of the rat heart
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[1] E. Shevach,et al. Foxp3‐mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells , 2015, Journal of leukocyte biology.
[2] M. Høydal,et al. Remote ischemic preconditioning preserves mitochondrial function and activates pro-survival protein kinase Akt in the left ventricle during cardiac surgery: a randomized trial. , 2014, International journal of cardiology.
[3] S. Zheng,et al. Doxycycline exerts multiple anti-allergy effects to attenuate murine allergic conjunctivitis and systemic anaphylaxis. , 2014, Biochemical pharmacology.
[4] T. Ouchi,et al. BRAT1 deficiency causes increased glucose metabolism and mitochondrial malfunction , 2014, BMC Cancer.
[5] R. Wanders,et al. Peripheral nervous system plasmalogens regulate Schwann cell differentiation and myelination. , 2014, The Journal of clinical investigation.
[6] Yu-Han Chen,et al. Protein kinase B (PKB/AKT1) formed signaling complexes with mitochondrial proteins and prevented glycolytic energy dysfunction in cultured cardiomyocytes during ischemia-reperfusion injury. , 2014, Endocrinology.
[7] G. Borm,et al. Aging attenuates the protective effect of ischemic preconditioning against endothelial ischemia-reperfusion injury in humans. , 2013, American journal of physiology. Heart and circulatory physiology.
[8] J. Mill,et al. Exercise training prior to myocardial infarction attenuates cardiac deterioration and cardiomyocyte dysfunction in rats , 2013, Clinics.
[9] D. Yellon,et al. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. , 2013, The Journal of clinical investigation.
[10] G. Porter,et al. Mitochondria as a Drug Target in Ischemic Heart Disease and Cardiomyopathy , 2012, Circulation research.
[11] Hong Ma,et al. Ischemic Postconditioning Mediates Cardioprotection Via PI3K/GSK-3&bgr;/&bgr;-Catenin Signaling Pathway in Ischemic Rat Myocardium , 2012, Shock.
[12] B. Hemmings,et al. The Akt1 isoform is an essential mediator of ischaemic preconditioning , 2012, Journal of cellular and molecular medicine.
[13] Jun Ren,et al. Ca+2/Calmodulin-Dependent Protein Kinase Mediates Glucose Toxicity-Induced Cardiomyocyte Contractile Dysfunction , 2012, Experimental diabetes research.
[14] E. Nagata,et al. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death , 2012, Proceedings of the National Academy of Sciences.
[15] D. Yellon,et al. Investigating the Signal Transduction Pathways Underlying Remote Ischemic Conditioning in the Porcine Heart , 2012, Cardiovascular Drugs and Therapy.
[16] M. Mocanu,et al. Retrograde heart perfusion: the Langendorff technique of isolated heart perfusion. , 2011, Journal of molecular and cellular cardiology.
[17] A. Degterev,et al. Small-molecule inhibitors of the PI3K signaling network. , 2011, Future medicinal chemistry.
[18] G. Lopaschuk,et al. Chronic Inhibition of Pyruvate Dehydrogenase in Heart Triggers an Adaptive Metabolic Response* , 2011, The Journal of Biological Chemistry.
[19] C. Terkelsen,et al. Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial , 2010, The Lancet.
[20] Pierre Croisille,et al. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. , 2008, The New England journal of medicine.
[21] M. Hayward,et al. Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial , 2007, The Lancet.
[22] M. Latronico,et al. Cardiac-specific overexpression of E40K active Akt prevents pressure overload-induced heart failure in mice by increasing angiogenesis and reducing apoptosis , 2007, Cell Death and Differentiation.
[23] J. Gwathmey,et al. STAT-3 activation is necessary for ischemic preconditioning in hypertrophied myocardium. , 2006, American journal of physiology. Heart and circulatory physiology.
[24] E. Abel,et al. Reduced Mitochondrial Oxidative Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity , 2005, Circulation.
[25] G. Finet,et al. Postconditioning the Human Heart , 2005, Circulation.
[26] M. Mocanu,et al. Preconditioning the diabetic heart: the importance of Akt phosphorylation. , 2005, Diabetes.
[27] D. Kass,et al. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. , 2005, The Journal of clinical investigation.
[28] S. Armstrong. Protein kinase activation and myocardial ischemia/reperfusion injury. , 2004, Cardiovascular research.
[29] G. Lopaschuk,et al. AMP-activated protein kinase (AMPK) control of fatty acid and glucose metabolism in the ischemic heart. , 2003, Progress in lipid research.
[30] G. Baxter. Role of adenosine in delayed preconditioning of myocardium. , 2002, Cardiovascular research.
[31] S. Cook,et al. Phenotypic Spectrum Caused by Transgenic Overexpression of Activated Akt in the Heart* , 2002, The Journal of Biological Chemistry.
[32] S. Cook,et al. Transcriptional Effects of Chronic Akt Activation in the Heart* , 2002, The Journal of Biological Chemistry.
[33] M. Mocanu,et al. PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning. , 2002, Journal of molecular and cellular cardiology.
[34] R. Hajjar,et al. Akt Activation Preserves Cardiac Function and Prevents Injury After Transient Cardiac Ischemia In Vivo , 2001, Circulation.
[35] R. London,et al. Preconditioning Enhanced Glucose Uptake Is Mediated by p38 MAP Kinase Not by Phosphatidylinositol 3-Kinase* , 2000, The Journal of Biological Chemistry.
[36] T. Yue,et al. Inhibition of extracellular signal-regulated kinase enhances Ischemia/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart. , 2000, Circulation research.
[37] R. Kitsis,et al. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. , 2000, Circulation.
[38] R. Virmani,et al. Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[39] D. Yellon,et al. Protein kinase C. Its role in ischemic preconditioning in the rat. , 1994, Circulation research.
[40] D. Yellon,et al. Preconditioning the human myocardium , 1993, The Lancet.
[41] T. Takala,et al. Effect of chronic exercise on glucose uptake and activities of glycolytic enzymes measured regionally in rat heart , 1989, Basic Research in Cardiology.
[42] J. Zweier,et al. Early ischaemic preconditioning requires Akt- and PKA-mediated activation of eNOS via serine1176 phosphorylation. , 2013, Cardiovascular research.
[43] www.elsevier.com/locate/cardiores Review C-reactive protein in atherosclerosis: A causal factor? , 2006 .
[44] L. Becker. Myocardial Reperfusion Injury , 2004, Journal of Thrombosis and Thrombolysis.
[45] E. Marbán,et al. The role of mitochondrial K(ATP) channels in cardioprotection. , 2000, Basic research in cardiology.