Toward a noninvasive estimate of interstitial fluid pressure by dynamic contrast‐enhanced MRI in a rat model of cerebral tumor

This study demonstrates a DCE‐MRI estimate of tumor interstitial fluid pressure (TIFP) and hydraulic conductivity in a rat model of glioblastoma, with validation against an invasive wick‐in‐needle (WIN) technique. An elevated TIFP is considered a mark of aggressiveness, and a decreased TIFP a predictor of response to therapy.

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