Studies of the quenching phenomenon in delayed contact hypersensitivity reactions

Studies in guinea pig and man have shown that eugenol can quench non‐specifically contact urticarial responses, whereas limonene seems largely ineffective In a comprehensive series of studies, there was little evidence of quenching of delayed contact hypersensitivity reactions to cinnamic aldehyde or citral, including in ‘pre‐quenched’ material supplied by a perfume flavour company, and in a similar mixture prepared in this laboratory, in the guinea pig model. In addition, there was no evidence of the quenching by eugenol of allergic reactions to cinnamic aldehyde in a panel of human subjects with a proven history of cinnamic‐aldehyde‐induced allergic contact dermatitis. Overall, the results lend little credibility to earlier literature reports of quenching phenomena in delayed contact hypersensitivity responses.

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