Distributed X-Ray Dosimetry With Optical Fibers by Optical Frequency Domain Interferometry

This article reports on the first demonstration of in situ, real-time dosimetry realized with an enhanced backscattering optical fiber, and a high-resolution optical backscattering reflectometry measurement. This work is devised to overcome the current problems in monitoring radiotherapy treatments, in particular, the difficult evaluation of not only the actual X-ray dose that is accumulated on the target volume but also the distribution profile of the ionizing radiation beam. Overall, the research aims at developing a dose sensor with the most demanding features of small form factor, spatial profiling, and remote interrogation. The experiments have been conducted by evaluating the spatial profile of radiation-induced spectral shift of the Rayleigh backscattering along an optical fiber exposed to X-rays. The sensing element is a section of specialty optical fiber whose Rayleigh backscattering signature changes under ionizing radiation. The specialty fiber is designed to exhibit an enhanced backscattering, in order to overcome the poor sensitivity to radiation of standard optical fibers that are normally, used in telecommunications. The enhanced sensitivity is achieved by doping the core with either aluminum or magnesium nanoparticles, and two different fibers have been fabricated and tested. The experimental results show the capability of real time detection of the radiation profile from high-dose rates (700 Gy/min) to low-dose rates (2 Gy/min). Moreover, different sensing mechanisms and responses to high- and low-dose rates are evidenced. A comparison with a quasi-distributed sensing system based on an array of fiber Bragg gratings (FBGs) is discussed, highlighting the superior performance of the backscattering approach in terms of sensitivity and spatial resolution, whereas the array of FBGs exhibits an advantage in terms of sampling speed.

[1]  Alessandro Mirigaldi,et al.  Temperature monitoring of tumor hyperthermal treatments with optical fibers: comparison of distributed and quasi-distributed techniques , 2020 .

[2]  Alessandro Mirigaldi,et al.  Preliminary investigation of radiation dose sensors based on aluminum-doped silicate optical fibers , 2020, 2020 IEEE International Symposium on Medical Measurements and Applications (MeMeA).

[3]  R. D. de Kruijff FLASH radiotherapy: ultra-high dose rates to spare healthy tissue , 2019, International journal of radiation biology.

[4]  Wilfried Blanc,et al.  Compositional Changes at the Early Stages of Nanoparticles Growth in Glasses , 2019, The Journal of Physical Chemistry C.

[5]  Kaushal Rege,et al.  Determination of topographical radiation dose profiles using gel nanosensors , 2019, Science Advances.

[6]  Youcef Ouerdane,et al.  Overview of radiation induced point defects in silica-based optical fibers , 2019, Reviews in Physics.

[7]  Thierry Robin,et al.  Qualification and Calibration of Single-Mode Phosphosilicate Optical Fiber for Dosimetry at CERN , 2019, Journal of Lightwave Technology.

[8]  Emiliano Schena,et al.  Multi-fiber distributed thermal profiling of minimally invasive thermal ablation with scattering-level multiplexing in MgO-doped fibers. , 2019, Biomedical optics express.

[9]  K. Harrington Ultrahigh Dose-rate Radiotherapy: Next Steps for FLASH-RT , 2018, Clinical Cancer Research.

[10]  Zhenyang Ding,et al.  Distributed Optical Fiber Sensors Based on Optical Frequency Domain Reflectometry: A review , 2018, Sensors.

[11]  Kevin P. Chen,et al.  High Spatial Resolution Radiation Detection Using Distributed Fiber Sensing Technique , 2017, IEEE Transactions on Nuclear Science.

[12]  A Nisbet,et al.  Comparison of methods for the measurement of radiation dose distributions in high dose rate (HDR) brachytherapy: Ge-doped optical fiber, EBT3 Gafchromic film, and PRESAGE® radiochromic plastic. , 2013, Medical physics.

[13]  Wilfried Blanc,et al.  Fabrication of Rare Earth‐Doped Transparent Glass Ceramic Optical Fibers by Modified Chemical Vapor Deposition , 2011, 1108.3195.

[14]  A. Micke,et al.  Multichannel film dosimetry with nonuniformity correction. , 2011, Medical physics.

[15]  B. Soller,et al.  High resolution optical frequency domain reflectometry for characterization of components and assemblies. , 2005, Optics express.

[16]  R. Kashyap Fiber Bragg Gratings , 1999 .

[17]  M. Froggatt,et al.  High-spatial-resolution distributed strain measurement in optical fiber with rayleigh scatter. , 1998, Applied optics.

[18]  L. Cognolato Chemical Vapour Deposition for Optical Fibre Technology , 1995 .

[19]  David N. Payne,et al.  Solution-doping technique for fabrication of rare-earth-doped optical fibres , 1987 .