Valine, the branched-chain amino acid, suppresses hepatitis C virus RNA replication but promotes infectious particle formation.

[1]  Haruo Watanabe,et al.  In vivo adaptation of hepatitis C virus in chimpanzees for efficient virus production and evasion of apoptosis , 2011, Hepatology.

[2]  M. Honda,et al.  Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C. , 2011, Gastroenterology.

[3]  N. Kato,et al.  Interferon-α-induced mTOR activation is an anti-hepatitis C virus signal via the phosphatidylinositol 3-kinase-Akt-independent pathway , 2009, Journal of Gastroenterology.

[4]  T. Wakita,et al.  Hepatitis C virus JFH‐1 strain infection in chimpanzees is associated with low pathogenicity and emergence of an adaptive mutation , 2008, Hepatology.

[5]  Y. Inoue,et al.  Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway. , 2007, Biochemical and biophysical research communications.

[6]  S. Lemon,et al.  p21-activated Kinase 1 Is Activated through the Mammalian Target of Rapamycin/p70 S6 Kinase Pathway and Regulates the Replication of Hepatitis C Virus in Human Hepatoma Cells* , 2007, Journal of Biological Chemistry.

[7]  J. Dubuisson,et al.  CD81 Expression Is Important for the Permissiveness of Huh7 Cell Clones for Heterogeneous Hepatitis C Virus Infection , 2007, Journal of Virology.

[8]  S. Lemon,et al.  Compensatory Mutations in E1, p7, NS2, and NS3 Enhance Yields of Cell Culture-Infectious Intergenotypic Chimeric Hepatitis C Virus , 2006, Journal of Virology.

[9]  K. Shimotohno,et al.  Enhancement of internal ribosome entry site-mediated translation and replication of hepatitis C virus by PD98059. , 2005, Virology.

[10]  L. Beretta,et al.  Activation of the N-Ras–PI3K–Akt-mTOR Pathway by Hepatitis C Virus: Control of Cell Survival and Viral Replication , 2005, Journal of Virology.

[11]  R. Bartenschlager,et al.  Production of infectious hepatitis C virus in tissue culture from a cloned viral genome , 2005, Nature Medicine.

[12]  T. Ohshima,et al.  Suppression of hepatitis C virus replicon by TGF-beta. , 2005, Virology.

[13]  Mauro Piacentini,et al.  Conventional Protein Kinase C Inhibition Prevents Alpha Interferon-Mediated Hepatitis C Virus Replicon Clearance by Impairing STAT Activation , 2004, Journal of Virology.

[14]  N. Hayashi,et al.  Involvement of p38 signaling pathway in interferon-alpha-mediated antiviral activity toward hepatitis C virus. , 2004, Biochemical and biophysical research communications.

[15]  Masahiko Kato,et al.  Oral Supplementation with Branched-Chain Amino Acids Improves Survival Rate of Rats with Carbon Tetrachloride-Induced Liver Cirrhosis , 1998, Digestive Diseases and Sciences.

[16]  Y. Eto,et al.  Branched-chain amino acids promote albumin synthesis in rat primary hepatocytes through the mTOR signal transduction system. , 2003, Biochemical and biophysical research communications.

[17]  I. Sonaka,et al.  Leucine promotes glucose uptake in skeletal muscles of rats. , 2002, Biochemical and biophysical research communications.

[18]  S. Lemon,et al.  Selectable Subgenomic and Genome-Length Dicistronic RNAs Derived from an Infectious Molecular Clone of the HCV-N Strain of Hepatitis C Virus Replicate Efficiently in Cultured Huh7 Cells , 2002, Journal of Virology.

[19]  S. Kimball,et al.  Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. , 2000, The Journal of nutrition.

[20]  J. Fischer,et al.  Plasma amino acids in patients with hepatic encephalopathy. Effects of amino acid infusions. , 1974, American journal of surgery.