Clinical outcome in pediatric glial and embryonal brain tumors correlates with in vitro multi‐passageable neurosphere formation

Cultured brain tumors can form neurospheres harboring tumorigenic cells with self renewal and differentiation capacities. Renewable neurosphere formation has clinical predictive value in adult malignant gliomas, yet its prognostic role for pediatric brain tumors is unknown.

[1]  Susan M. Chang,et al.  Pediatric brain tumors: Current treatment strategies and future therapeutic approaches , 2009, Neurotherapeutics.

[2]  M. Kieran,et al.  Small molecule inhibitors in children with malignant gliomas , 2009, Pediatric blood & cancer.

[3]  L. Margraf,et al.  Predictors of tumor progression among children with gangliogliomas. Clinical article. , 2009, Journal of neurosurgery. Pediatrics.

[4]  S. Horvath,et al.  Neurosphere Formation Is an Independent Predictor of Clinical Outcome in Malignant Glioma , 2009, Stem cells.

[5]  I. Nakano,et al.  Cancer stem cells in pediatric brain tumors. , 2004, Current stem cell research & therapy.

[6]  N. Jersey..  Predictors of tumor progression among children with gangliogliomas , 2009 .

[7]  S. Orkin.  Oncology of infancy and childhood , 2009 .

[8]  L. Ricci-Vitiani,et al.  Cancer Stem Cell Analysis and Clinical Outcome in Patients with Glioblastoma Multiforme , 2008, Clinical Cancer Research.

[9]  T. Merchant,et al.  High‐grade astrocytoma in very young children , 2007, Pediatric blood & cancer.

[10]  B. Scheithauer,et al.  The 2007 WHO classification of tumours of the central nervous system , 2007, Acta Neuropathologica.

[11]  Yuri Kotliarov,et al.  Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. , 2006, Cancer cell.

[12]  R. Henkelman,et al.  Identification of human brain tumour initiating cells , 2004, Nature.

[13]  H. Budka,et al.  Ki-67 Immunolabeling Index Is an Accurate Predictor of Outcome in Patients With Intracranial Ependymoma , 2004, The American journal of surgical pathology.

[14]  D. Frappaz,et al.  Progression-free survival in children with optic pathway tumors: dependence on age and the quality of the response to chemotherapy--results of the first French prospective study for the French Society of Pediatric Oncology. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[15]  Daniel H. Geschwind,et al.  Cancerous stem cells can arise from pediatric brain tumors , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[16]  S. Torp.  Diagnostic and prognostic role of Ki67 immunostaining in human astrocytomas using four different antibodies. , 2002, Clinical neuropathology.

[17]  James M Boyett,et al.  Impact of Proliferation Index on Outcome in Childhood Malignant Gliomas: Results in a Multi-institutional Cohort , 2002, Neurosurgery.

[18]  G. Reifenberger,et al.  The WHO Classification of Tumors of the Nervous System , 2002, Journal of neuropathology and experimental neurology.

[19]  A. Albright.  Pediatric brain tumors. , 1993, CA: a cancer journal for clinicians.