EVIDENCE OF A GENETIC BASIS FOR KELOID DISEASE

Copyright © 2012 The Korean Society of Plastic and Reconstructive Surgeons This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. www.e-aps.org INTRODUCTION

[1]  J. Jiang,et al.  Analyses of CDC2L1 gene mutations in keloid tissue , 2012, Clinical and experimental dermatology.

[2]  A. Bayat,et al.  Extracellular matrix molecules implicated in hypertrophic and keloid scarring , 2012, Journal of the European Academy of Dermatology and Venereology : JEADV.

[3]  Yusuke Nakamura,et al.  Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production , 2011, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

[4]  R. Chalmers.  The evidence for the role of transforming growth factor‐beta in the formation of abnormal scarring , 2011, International wound journal.

[5]  A. Bayat,et al.  A Clinical Characterization of Familial Keloid Disease in Unique African Tribes Reveals Distinct Keloid Phenotypes , 2011, Plastic and reconstructive surgery.

[6]  Scott M. Williams,et al.  Epigenetically altered wound healing in keloid fibroblasts. , 2010, The Journal of investigative dermatology.

[7]  Yusuke Nakamura,et al.  A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population , 2010, Nature Genetics.

[8]  Liangdan Sun,et al.  Association of HLA-DRB1 alleles with keloids in Chinese Han individuals. , 2010, Tissue antigens.

[9]  A. Bayat,et al.  Genetics of keloid scarring , 2010, Archives of Dermatological Research.

[10]  A. Aloysius,et al.  Natural history of Ullrich congenital muscular dystrophy , 2009, Neurology.

[11]  W. Thomson,et al.  Positive association of HLA‐DRB1*15 with keloid disease in Caucasians , 2008, International journal of immunogenetics.

[12]  J. Lamb,et al.  Genetic susceptibility to Keloid scarring: SMAD gene SNP frequencies in Afro‐Caribbeans , 2008, Experimental dermatology.

[13]  Youxin Jin,et al.  Inhibition of Smad3 expression decreases collagen synthesis in keloid disease fibroblasts. , 2007, Journal of plastic, reconstructive & aesthetic surgery : JPRAS.

[14]  Q. Zhuang,et al.  [Association between p53 gene codon 72 polymorphism and keloid in Chinese population]. , 2007, Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery.

[15]  Jian-hua Gao,et al.  [Location of predisposing gene for one Han Chinese keloid pedigree]. , 2007, Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery.

[16]  Jian-hua Gao,et al.  Characteristics of occurrence for Han Chinese familial keloids. , 2006, Burns : journal of the International Society for Burn Injuries.

[17]  Youxin Jin,et al.  Modulation of Collagen Synthesis in Keloid Fibroblasts by Silencing Smad2 with siRNA , 2006, Plastic and reconstructive surgery.

[18]  R. W. Miller,et al.  Keloids and neoplasms in the Rubinstein-Taybi syndrome. , 2006, Medical and pediatric oncology.

[19]  Jian-hua Gao,et al.  [Linkage analysis of keloid susceptibility loci on chromosome 7p11 in a Chinese pedigree]. , 2006, Nan fang yi ke da xue xue bao = Journal of Southern Medical University.

[20]  A. Bayat,et al.  Genetic susceptibility to keloid disease: mutation screening of the TGFbeta3 gene. , 2005, British journal of plastic surgery.

[21]  A. Ooshima,et al.  Upregulation of transforming growth factor-β1 and vascular endothelial growth factor in cultured keloid fibroblasts: relevance to angiogenic activity , 2005, Archives of Dermatological Research.

[22]  A. P. Kelly.  Medical and surgical therapies for keloids , 2004, Dermatologic therapy.

[23]  B. Olsen,et al.  Genome scans provide evidence for keloid susceptibility loci on chromosomes 2q23 and 7p11. , 2004, The Journal of investigative dermatology.

[24]  A. Bayat,et al.  Genetic susceptibility to keloid disease: Transforming growth factor β receptor gene polymorphisms are not associated with keloid disease , 2004, Experimental dermatology.

[25]  A. Bayat,et al.  "Aggressive keloid": a severe variant of familial keloid scarring. , 2003, Journal of the Royal Society of Medicine.

[26]  Ardeshir Bayat,et al.  Genetic Susceptibility to Keloid Disease and Hypertrophic Scarring: Transforming Growth Factor &bgr;1 Common Polymorphisms and Plasma Levels , 2003, Plastic and reconstructive surgery.

[27]  A Bayat,et al.  Genetic susceptibility to keloid disease and transforming growth factor beta 2 polymorphisms. , 2002, British journal of plastic surgery.

[28]  Susan C. Taylor,et al.  Keloidal scars: a review with a critical look at therapeutic options. , 2002, Journal of the American Academy of Dermatology.

[29]  B. Olsen,et al.  Clinical genetics of familial keloids. , 2001, Archives of dermatology.

[30]  J. Canady,et al.  Effects of TGFbeta2 on collagen synthesis in cultured normal and wounded fetal mouse palates. , 1999, The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.

[31]  Child,et al.  A study of the spectrum of skin disease occurring in a black population in south‐east London , 1999, The British journal of dermatology.

[32]  G. Huang,et al.  Effect of TGF-beta 1 on PDGF receptors expression in human scar fibroblasts. , 1998, Frontiers in bioscience : a journal and virtual library.

[33]  I. K. Cohen,et al.  The effect of TGF-beta on keloid fibroblast proliferation and collagen synthesis. , 1996, Plastic and reconstructive surgery.

[34]  Raoul C. M. Hennekam,et al.  Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP , 1995, Nature.

[35]  R. Timpl,et al.  Activation of collagen gene expression in keloids: co-localization of type I and VI collagen and transforming growth factor-beta 1 mRNA. , 1991, The Journal of investigative dermatology.

[36]  I. LeFlore.  Misconceptions regarding elective plastic surgery in the black patient. , 1980, Journal of the National Medical Association.

[37]  P. Omo-Dare.  Genetic studies on keloid. , 1975, Journal of the National Medical Association.

[38]  K. Thomas,et al.  STUDY OF 1,000 PATIENTS WITH KELOIDS IN SOUTH INDIA , 1974, Plastic and reconstructive surgery.

[39]  S. M. Alhady.  KELOIDS IN VARIOUS RACES A Review of 175 Cases , 1969, Plastic and reconstructive surgery.

[40]  L. Goeminne.  A new probably X-linked inherited syndrome: congenital muscular torticollis, multiple keloids cryptorchidism and renal dysplasia. , 1968, Acta geneticae medicae et gemellologiae.

[41]  A. Bayat,et al.  Comparative genomic hybridisation analysis of keloid tissue in Caucasians suggests possible involvement of HLA-DRB5 in disease pathogenesis , 2012, Archives of dermatological research.

[42]  Jian-hua Gao,et al.  [Preliminary linkage analysis and mapping of keloid susceptibility locus in a Chinese pedigree]. , 2007, Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery.

[43]  T. Spector,et al.  Genetic control of the circulating concentration of transforming growth factor type beta1. , 1999, Human molecular genetics.

[44]  H. Murata,et al.  TGF-beta3 stimulates and regulates collagen synthesis through TGF-beta1-dependent and independent mechanisms. , 1997, The Journal of investigative dermatology.