Eosinophil-derived IFN-gamma induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes.

[1]  A. Klion Hypereosinophilic syndrome: current approach to diagnosis and treatment. , 2009, Annual review of medicine.

[2]  A. Billiau,et al.  How interferon-gamma keeps autoimmune diseases in check. , 2008, Trends in immunology.

[3]  A. August,et al.  Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma , 2008, The Journal of experimental medicine.

[4]  A. Kanda,et al.  Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis. , 2008, The Journal of allergy and clinical immunology.

[5]  J. Parkin,et al.  Treatment of patients with the hypereosinophilic syndrome with mepolizumab. , 2008, The New England journal of medicine.

[6]  James J. Lee,et al.  Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells , 2008, The Journal of experimental medicine.

[7]  V. Verhasselt,et al.  Breast milk–mediated transfer of an antigen induces tolerance and protection from allergic asthma , 2008, Nature Medicine.

[8]  M. Capron,et al.  Innate immune function of eosinophils: from antiparasite to antitumor cells. , 2008, Methods in molecular biology.

[9]  P. O'Byrne The demise of anti IL-5 for asthma, or not. , 2007, American journal of respiratory and critical care medicine.

[10]  Toshio Tanaka,et al.  T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-γ and IL-13 production , 2007, Proceedings of the National Academy of Sciences.

[11]  J. Mcghee,et al.  Th1 and Th2 cells are required for both eosinophil- and neutrophil-associated airway inflammatory responses in mice. , 2007, Biochemical and biophysical research communications.

[12]  Satoru Takahashi,et al.  Transcription factors T-bet and GATA-3 regulate development of airway remodeling. , 2006, American journal of respiratory and critical care medicine.

[13]  D. Voehringer,et al.  Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system , 2006, The Journal of experimental medicine.

[14]  C. Bogdan,et al.  Production of interferon-γ by myeloid cells – fact or fancy? , 2006 .

[15]  J. Goldblatt,et al.  An immunoepidemiological approach to asthma: identification of in-vitro T cell response patterns associated with different wheezing phenotypes in children , 2005, The Lancet.

[16]  Rakesh K. Kumar,et al.  Effects of anticytokine therapy in a mouse model of chronic asthma. , 2004, American journal of respiratory and critical care medicine.

[17]  S. Orkin,et al.  A Critical Role for Eosinophils in Allergic Airways Remodeling , 2004, Science.

[18]  E. Lenkiewicz,et al.  Defining a Link with Asthma in Mice Congenitally Deficient in Eosinophils , 2004, Science.

[19]  S. Phipps,et al.  A role for eosinophils in airway remodelling in asthma. , 2004, Trends in immunology.

[20]  K. Schroder,et al.  Interferon- : an overview of signals, mechanisms and functions , 2004 .

[21]  H. Kita,et al.  Marked Airway Eosinophilia Prevents Development of Airway Hyper-responsiveness During an Allergic Response in IL-5 Transgenic Mice1 , 2003, The Journal of Immunology.

[22]  James J. Lee,et al.  A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies , 2003 .

[23]  P. O'Byrne,et al.  Effect of Interferon-γ on Allergic Airway Responses in Interferon-γ–deficient Mice , 2002 .

[24]  S. Pestka,et al.  Interferon‐γ receptor 2 expression as the deciding factor in human T, B, and myeloid cell proliferation or death , 2001, Journal of leukocyte biology.

[25]  K. Chung,et al.  Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response , 2000, The Lancet.

[26]  P. Weller,et al.  Lymph node trafficking and antigen presentation by endobronchial eosinophils. , 2000, The Journal of clinical investigation.

[27]  Ochiai,et al.  Role of JAK2 signal transductional pathway in activation and survival of human peripheral eosinophils by interferon‐gamma (IFN‐γ) , 1999, Clinical and experimental immunology.

[28]  A. Capron,et al.  Expression of Cd28 and Cd86 by Human Eosinophils and Role in the Secretion of Type 1 Cytokines (Interleukin 2 and Interferon γ) , 1999, The Journal of experimental medicine.

[29]  T. Sandström,et al.  Interleukin-5 production by human airway epithelial cells. , 1999, American journal of respiratory cell and molecular biology.

[30]  I. van Ark,et al.  Differential Effects of Endogenous and Exogenous Interferon- γ on Immunoglobulin E, Cellular Infiltration, and Airway Responsiveness in a Murine Model of Allergic Asthma , 1998 .

[31]  S. Yoshida,et al.  Human peripheral eosinophils express functional interferon‐gamma receptors (IFN‐γR) , 1997, Clinical and experimental immunology.

[32]  C. Bertrand,et al.  Mice lacking the IFN-gamma receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile. , 1996, Journal of immunology.

[33]  A. Bradley,et al.  Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. , 1993, Science.

[34]  H. Nakajima,et al.  Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells , 1993, The Journal of experimental medicine.

[35]  J. Kalden,et al.  Effects of IFN on human eosinophils in comparison with other cytokines. A novel class of eosinophil activators with delayed onset of action. , 1990, Journal of immunology.

[36]  M. Strath,et al.  Eosinophilia in transgenic mice expressing interleukin 5 , 1990, The Journal of experimental medicine.

[37]  W. Rutter,et al.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. , 1979, Biochemistry.