The chosen few? Positive selection and the generation of naive B lymphocytes.
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[1] S. Pillai,et al. Accelerated emigration of B lymphocytes in the Xid mouse. , 1999, Journal of immunology.
[2] J. Monroe,et al. Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter. , 1999, Immunity.
[3] F. Alt,et al. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. , 1999, Science.
[4] Y. Yazaki,et al. Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. , 1999, Science.
[5] L. Glimcher,et al. Transcription Factors in Lymphocyte Development— T and B Cells Get Together , 1999, Cell.
[6] F. Alt,et al. Activated Ras Signals Developmental Progression of Recombinase-activating Gene (RAG)-deficient Pro-B Lymphocytes , 1999, The Journal of experimental medicine.
[7] A. Rolink,et al. Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity , 1998, European journal of immunology.
[8] B. Morgan,et al. Aiolos regulates B cell activation and maturation to effector state. , 1998, Immunity.
[9] S. Clarke,et al. B-1 Cell Development: Evidence for an Uncommitted Immunoglobulin (Ig)M+ B Cell Precursor in B-1 Cell Differentiation , 1998, The Journal of experimental medicine.
[10] Wei Wei Wu,et al. Transgene Expression of bcl-xL Permits Anti-immunoglobulin (Ig)–induced Proliferation in xid B Cells , 1998, The Journal of experimental medicine.
[11] I. Maclennan. B-cell receptor regulation of peripheral B cells. , 1998, Current opinion in immunology.
[12] F. Melchers,et al. Murine B lymphopoiesis: towards a unified model. , 1998, Immunology today.
[13] A. Rolink,et al. Precursor B cells showing H chain allelic inclusion display allelic exclusion at the level of pre-B cell receptor surface expression. , 1998, Immunity.
[14] W. Sha. Regulation of Immune Responses by NF-κB/Rel Transcription Factors , 1998, The Journal of experimental medicine.
[15] D. Campana,et al. Mutations in the Human λ5/14.1 Gene Result in B Cell Deficiency and Agammaglobulinemia , 1998, The Journal of experimental medicine.
[16] M. Tomayko,et al. Long-lived B cells are distinguished by elevated expression of A1. , 1998, Journal of immunology.
[17] Ulrich Siebenlist,et al. Requirement for NF-κB in osteoclast and B-cell development , 1997 .
[18] M. Turner,et al. Syk Tyrosine Kinase Is Required for the Positive Selection of Immature B Cells into the Recirculating B Cell Pool , 1997, The Journal of experimental medicine.
[19] L. Corcoran,et al. oct-2 gene disruption eliminates the peritoneal B-1 lymphocyte lineage and attenuates B-2 cell maturation and function. , 1997, Journal of immunology.
[20] K. Rajewsky,et al. Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification. , 1997, Immunity.
[21] C. Atkins,et al. A re‐evaluation of the effects of X‐linked immunodeficiency (xid) mutation on B cell differentiation and function in the mouse , 1997, European journal of immunology.
[22] R. Geha,et al. Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[23] K. Rajewsky,et al. In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death , 1997, Cell.
[24] M. Neuberger. Antigen Receptor Signaling Gives Lymphocytes a Long Life , 1997, Cell.
[25] J. Kearney,et al. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses , 1997, European journal of immunology.
[26] M. Cook,et al. Outer Periarteriolar Lymphoid Sheath Arrest and Subsequent Differentiation of Both Naive and Tolerant Immunoglobulin Transgenic B Cells Is Determined by B Cell Receptor Occupancy , 1997, The Journal of experimental medicine.
[27] A. Shaffer,et al. A truncated heavy chain protein relieves the requirement for surrogate light chains in early B cell development. , 1997, Journal of immunology.
[28] K. Campbell,et al. Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81 , 1997, The EMBO journal.
[29] Philippe Soriano,et al. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. , 1997, Immunity.
[30] F. Lemonnier,et al. Differential requirements for survival and proliferation of CD8 naïve or memory T cells. , 1997, Science.
[31] A. Basten,et al. Influences on the lifespan of B cell subpopulations defined by different phenotypes , 1997, European journal of immunology.
[32] S. Levy,et al. Normal Lymphocyte Development but Delayed Humoral Immune Response in CD81-null Mice , 1997, The Journal of experimental medicine.
[33] D. Nemazee,et al. BCR ligation induces receptor editing in IgM+IgD- bone marrow B cells in vitro. , 1997, Immunity.
[34] A. Tarakhovsky. Bar Mitzvah for B-1 Cells: How Will They Grow Up? , 1997, The Journal of experimental medicine.
[35] J. Karras,et al. Signal Transducer and Activator of Transcription-3 (STAT3) Is Constitutively Activated in Normal, Self-renewing B-1 Cells but Only Inducibly Expressed in Conventional B Lymphocytes , 1997, The Journal of experimental medicine.
[36] R. Perlmutter,et al. Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone. , 1997, International immunology.
[37] R. Perlmutter,et al. CD22 regulates thymus-independent responses and the lifespan of B cells , 1996, Nature.
[38] S. Bondada,et al. CD5-Mediated Negative Regulation of Antigen Receptor-Induced Growth Signals in B-1 B Cells , 1996, Science.
[39] A. Miller,et al. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. , 1996, Immunity.
[40] W. Schaffner,et al. B lymphocytes are impaired in mice lacking the transcriptional co‐activator Bob1/OCA‐B/OBF1 , 1996, European journal of immunology.
[41] D. Campana,et al. Mutations in the mu heavy-chain gene in patients with agammaglobulinemia. , 1996, The New England journal of medicine.
[42] M. Neuberger,et al. Hyperresponsive B Cells in CD22-Deficient Mice , 1996, Science.
[43] Shiaoching Gong,et al. The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes , 1996, Nature.
[44] A. Rolink,et al. B-cell-specif ic coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation , 1996, Nature.
[45] H. Wortis,et al. An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[46] F. Grosveld,et al. Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre‐B cell stage. , 1996, The EMBO journal.
[47] T. Watanabe,et al. Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice , 1996, The Journal of experimental medicine.
[48] A. Tarakhovsky,et al. Immunodeficiency in Protein Kinase Cβ-Deficient Mice , 1996, Science.
[49] T. Kurosaki,et al. A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2 , 1996, The Journal of experimental medicine.
[50] K. Rajewsky. Clonal selection and learning in the antibody system , 1996, Nature.
[51] K. Rajewsky,et al. Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex , 1996, Science.
[52] T. Mak,et al. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45 , 1996, Nature.
[53] J. Miyazaki,et al. Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice. , 1996, Immunity.
[54] Michel C. Nussenzweig,et al. Regulation of an Early Developmental Checkpoint in the B Cell Pathway by Igβ , 1996, Science.
[55] R. Karr,et al. Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[56] S. Clarke,et al. The transition of pre‐BI to pre‐BII cells is dependent on the VH structure of the mu/surrogate L chain receptor. , 1996, The EMBO journal.
[57] D. Alexander,et al. CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation , 1996, The Journal of experimental medicine.
[58] C. Goodnow. Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[59] J. Ahearn,et al. Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. , 1996, Immunity.
[60] R. Hardy,et al. Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgene. , 1996, Immunity.
[61] A. Rolink,et al. Surrogate light chain in B cell development. , 1993, Advances in immunology.
[62] P. Hodgkin,et al. IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. , 1996, Immunity.
[63] D. Baltimore,et al. B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching. , 1996, Journal of immunology.
[64] H. Jäck,et al. Surrogate light chain-dependent selection of Ig heavy chain V regions. , 1995, Journal of immunology.
[65] Tony Pawson,et al. Syk tyrosine kinase required for mouse viability and B-cell development , 1995, Nature.
[66] Victor L. J. Tybulewicz,et al. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk , 1995, Nature.
[67] T. Yamamoto,et al. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. , 1995, Immunity.
[68] S. Stacker,et al. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease , 1995, Cell.
[69] J. Cesbron,et al. Pre-B-cell development in the absence of λ5 in transgenic mice expressing a heavy-chain disease protein , 1995, Current Biology.
[70] R. Perlmutter,et al. Impaired expansion of mouse B cell progenitors lacking Btk. , 1995, Immunity.
[71] F. Alt,et al. Defective B cell development and function in Btk-deficient mice. , 1995, Immunity.
[72] Klaus Rajewsky,et al. Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice , 1995, Nature.
[73] B. Koller,et al. Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. , 1995, Immunity.
[74] G. Köhler,et al. Transitional B cells are the target of negative selection in the B cell compartment , 1995, The Journal of experimental medicine.
[75] F. Alt,et al. Bclx regulates the survival of double-positive thymocytes. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[76] F. Alt,et al. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene , 1995, Nature.
[77] K. Rajewsky,et al. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav , 1995, Nature.
[78] al. et,et al. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice , 1995, Science.
[79] David Baltimore,et al. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses , 1995, Cell.
[80] J. Cyster,et al. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. , 1995, Immunity.
[81] L. Corcoran,et al. Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation. , 1994, Immunity.
[82] J. Cyster,et al. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire , 1994, Nature.
[83] K. Isselbacher,et al. Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[84] L. Ding,et al. Developmental regulation of the Bcl‐2 protein and susceptibility to cell death in B lymphocytes. , 1994, The EMBO journal.
[85] M. Cancro,et al. Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. , 1993, Journal of immunology.
[86] S. Korsmeyer,et al. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair , 1993, Cell.
[87] V. Stewart,et al. Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. , 1993, Science.
[88] F. Alt,et al. Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. , 1993, International immunology.
[89] J. Cambier,et al. The B‐Cell Antigen Receptor: Structure and Function of Primary, Secondary, Tertiary and Quaternary Components , 1993, Immunological reviews.
[90] J Erikson,et al. B lymphocytes may escape tolerance by revising their antigen receptors , 1993, The Journal of experimental medicine.
[91] D. Nemazee,et al. Receptor editing in self-reactive bone marrow B cells , 1993, The Journal of experimental medicine.
[92] K. Rajewsky,et al. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development , 1993, Cell.
[93] A. Whitmore,et al. B-1 cells are made, not born. , 1993, Immunology today.
[94] Ornella Parolini,et al. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia , 1993, Cell.
[95] D. Bentley,et al. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases , 1993, Nature.
[96] L. Herzenberg,et al. Origin of murine B cell lineages. , 1993, Annual review of immunology.
[97] K. Rajewsky,et al. A critical role of λ5 protein in B cell development , 1992, Cell.
[98] M. Reth. Antigen receptors on B lymphocytes. , 1992, Annual review of immunology.
[99] H. Wortis. Surface markers, heavy chain sequences and B cell lineages. , 1992, International reviews of immunology.
[100] R. Hardy,et al. A developmental switch in B lymphopoiesis. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[101] C. Goodnow,et al. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens , 1991, Nature.
[102] K. Rajewsky,et al. Most peripheral B cells in mice are ligand selected , 1991, The Journal of experimental medicine.
[103] H. Wortis,et al. Treatment of murine CD5- B cells with anti-Ig, but not LPS, induces surface CD5: two B-cell activation pathways. , 1991, International immunology.
[104] J D Kemp,et al. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow , 1991, The Journal of experimental medicine.
[105] Klaus Rajewsky,et al. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene , 1991, Nature.
[106] S. Pillai. Immunoglobulin transport in B cell development. , 1991, International review of cytology.
[107] K. Rajewsky,et al. The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[108] D. Nemazee,et al. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes , 1989, Nature.
[109] S. Smith‐Gill,et al. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice , 1988, Nature.
[110] L. Herzenberg,et al. The LY‐1B Cell Lineage , 1986 .
[111] D. G. Osmond,et al. Population Dynamics of Bone Marrow B Lymphocytes , 1986, Immunological reviews.
[112] R. Hardy,et al. The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice , 1983, The Journal of experimental medicine.
[113] D. Gray,et al. The lymphocytes of splenic marginal zones: a distinct B-cell lineage. , 1982, Immunology today.