论文信息 - Agricultural pest control with CRISPR‐based gene drive: time for public debate

Agricultural pest control with CRISPR‐based gene drive: time for public debate

Gene drive technology to control disease vectors or pests has great potential for addressing humanitarian and public health problems. Its application for pest control in agriculture, however, raises important environmental, social and ethical issues.

[1] Austin Burt,et al. Site-specific selfish genes as tools for the control and genetic engineering of natural populations , 2003, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[2] Division on Earth. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values , 2016 .

[3] Andrea Crisanti,et al. A CRISPR-Cas 9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae , 2015 .

[4] Andrea Crisanti,et al. A CRISPR-Cas9 Gene Drive System Targeting Female Reproduction in the Malaria Mosquito vector Anopheles gambiae , 2015, Nature Biotechnology.

[5] Ethan Bier,et al. The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations , 2015, Science.

[6] Ethan Bier,et al. Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi , 2015, Proceedings of the National Academy of Sciences.

[7] George M Church,et al. Concerning RNA-guided gene drives for the alteration of wild populations , 2014, bioRxiv.