Di(2-ethylhexyl) phthalate-induced toxicity and peroxisome proliferator-activated receptor alpha: a review

[1]  Han-Bin Huang,et al.  Prenatal and childhood exposure to phthalate diesters and neurobehavioral development in a 15-year follow-up birth cohort study. , 2019, Environmental research.

[2]  F. Gonzalez,et al.  In utero exposure to di(2-ethylhexyl)phthalate suppresses blood glucose and leptin levels in the offspring of wild-type mice. , 2019, Toxicology.

[3]  V. Cogliano.  International Agency for Research on Cancer (IARC) , 2018, The Grants Register 2019.

[4]  M. Murata.  Inflammation and cancer , 2018, Environmental Health and Preventive Medicine.

[5]  Sai Sandeep Singh Rowdhwal,et al.  Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview , 2018, BioMed research international.

[6]  R. Kishi,et al.  Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido study on Environment and Children's Health , 2018, Environmental research.

[7]  Virunya S Bhat,et al.  Derivation of an oral reference dose (RfD) for di 2-ethylhexyl cyclohexan-1,4-dicarboxylate (DEHCH), an alternative to phthalate plasticizers. , 2018, Regulatory toxicology and pharmacology : RTP.

[8]  J. Corton,et al.  The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions , 2017, Archives of Toxicology.

[9]  G. Wei,et al.  Protective effects of vitamin E against reproductive toxicity induced by di(2-ethylhexyl) phthalate via PPAR-dependent mechanisms , 2017, Toxicology mechanisms and methods.

[10]  C. Hsiung,et al.  Prenatal and childhood exposure to phthalate diesters and sex steroid hormones in 2-, 5-, 8-, and 11-year-old children: A pilot study of the Taiwan Maternal and Infant Cohort Study , 2017, Journal of epidemiology.

[11]  S. Kersten,et al.  The role and regulation of the peroxisome proliferator activated receptor alpha in human liver. , 2017, Biochimie.

[12]  Prenatal di(2-ethylhexyl) phthalate exposure and disruption of adrenal androgens and glucocorticoids levels in cord blood: The Hokkaido Study. , 2017, The Science of the total environment.

[13]  Richard C. Thompson,et al.  Relative importance of microplastics as a pathway for the transfer of hydrophobic organic chemicals to marine life. , 2016, Environmental pollution.

[14]  Warren Mallon.  Occupational exposure limits , 2016 .

[15]  C. Hsiung,et al.  Intake of phthalate-tainted foods and microalbuminuria in children: The 2011 Taiwan food scandal. , 2016, Environment international.

[16]  Yuki Ito,et al.  Prenatal Exposure to Di(2-ethylhexyl) phthalate and Subsequent Infant and Child Health Effects , 2015 .

[17]  F. Galgani,et al.  Global Distribution, Composition and Abundance of Marine Litter , 2015 .

[18]  R. Kishi,et al.  Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study , 2015, Environmental Health and Preventive Medicine.

[19]  Lucas Smith,et al.  Classification, packaging and labelling of dangerous substances , 2014 .

[20]  M. Maríc,et al.  Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure , 2014, Applied Microbiology and Biotechnology.

[21]  D. Bourdeaux,et al.  Analytical methods for the determination of DEHP plasticizer alternatives present in medical devices: a review. , 2014, Talanta.

[22]  T. Mitsui,et al.  Association between Maternal Exposure to di(2-ethylhexyl) Phthalate and Reproductive Hormone Levels in Fetal Blood: The Hokkaido Study on Environment and Children's Health , 2014, PloS one.

[23]  M. Kamijima,et al.  Fenitrothion action at the endocannabinoid system leading to spermatotoxicity in Wistar rats. , 2014, Toxicology and applied pharmacology.

[24]  M. Bloom,et al.  Reproductive and developmental effects of phthalate diesters in males , 2014, Critical reviews in toxicology.

[25]  Yuki Ito,et al.  Effects of exposure to Di(2-ethylhexyl)phthalate 
during fetal period on next generation. , 2014, Nihon eiseigaku zasshi. Japanese journal of hygiene.

[26]  A. Malekirad,et al.  Occupational Exposure Limits , 2014 .

[27]  M. Kamijima,et al.  Species and inter-individual differences in metabolic capacity of di(2-ethylhexyl)phthalate (DEHP) between human and mouse livers , 2014, Environmental Health and Preventive Medicine.

[28]  Martin Ebert,et al.  Identification of polymer types and additives in marine microplastic particles using pyrolysis-GC/MS and scanning electron microscopy. , 2013, Environmental science. Processes & impacts.

[29]  M. Kamijima,et al.  Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice. , 2013, Toxicology.

[30]  이창훈,et al.  Bis(2-ethylhexyl)phthalate (DEHP)에 대한 매체통합 생태위해성평가 , 2013 .

[31]  C. Chambers,et al.  Reproductive and developmental effects of phthalate diesters in females , 2013, Critical reviews in toxicology.

[32]  Some chemicals present in industrial and consumer products, food and drinking-water. , 2013, IARC monographs on the evaluation of carcinogenic risks to humans.

[33]  Doni Hikmat Ramdhan,et al.  Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver , 2012, PPAR research.

[34]  Yuki Ito,et al.  胎生期フタル酸ジ-2-エチルヘキシル曝露による低栄養環境と生活習慣病 , 2012 .

[35]  Yuki Ito,et al.  [Relationship of maternal malnutrition caused by Di(2-ethylhexyl) phthalate exposure with lifestyle disease in offspring]. , 2012, Nihon eiseigaku zasshi. Japanese journal of hygiene.

[36]  M. Kamijima,et al.  Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice , 2011, Archives of Toxicology.

[37]  D. H. Ramdhan,et al.  Hepatic peroxisome proliferator-activated receptor α may have an important role in the toxic effects of di(2-ethylhexyl)phthalate on offspring of mice. , 2011, Toxicology.

[38]  Bung-Nyun Kim,et al.  Prenatal Exposure to Phthalates and Infant Development at 6 Months: Prospective Mothers and Children’s Environmental Health (MOCEH) Study , 2011, Environmental health perspectives.

[39]  A. Calafat,et al.  Prenatal exposure to bisphenol A and phthalates and infant neurobehavior. , 2011, Neurotoxicology and teratology.

[40]  J. Angerer,et al.  Phthalate exposure in pregnant women and their children in central Taiwan. , 2011, Chemosphere.

[41]  Droits civils,et al.  Consumer Product Safety Improvement Act , 2010 .

[42]  Paul A. Schulte,et al.  Research Recommendations for Selected IARC-Classified Agents , 2010, Environmental health perspectives.

[43]  J. Corton,et al.  Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.

[44]  D. H. Ramdhan,et al.  Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor alpha, but not human PPARalpha. , 2009, Toxicology.

[45]  Weihsueh A. Chiu,et al.  A Reexamination of the PPAR-α Activation Mode of Action as a Basis for Assessing Human Cancer Risks of Environmental Contaminants , 2009, Environmental health perspectives.

[46]  Yuki Ito,et al.  PPARα- and DEHP-Induced Cancers , 2008, PPAR research.

[47]  Yuki Ito,et al.  Different Mechanisms of DEHP‐induced Hepatocellular Adenoma Tumorigenesis in Wild‐type and Pparα‐null Mice , 2008, Journal of occupational health.

[48]  F. Gonzalez,et al.  The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha. , 2008, Toxicological sciences : an official journal of the Society of Toxicology.

[49]  F. Gonzalez,et al.  The PPARα-Humanized Mouse: A Model to Investigate Species Differences in Liver Toxicity Mediated by PPARα , 2008 .

[50]  Yuki Ito,et al.  Di(2‐ethylhexyl)phthalate Induces Hepatic Tumorigenesis through a Peroxisome Proliferator‐activated Receptor α‐independent Pathway , 2007 .

[51]  F. Gonzalez,et al.  Peroxisome proliferator-activated receptor alpha protects against glomerulonephritis induced by long-term exposure to the plasticizer di-(2-ethylhexyl)phthalate. , 2007, Journal of the American Society of Nephrology : JASN.

[52]  Yuki Ito,et al.  Di(2-ethylhexyl)phthalate induces hepatic tumorigenesis through a peroxisome proliferator-activated receptor alpha-independent pathway. , 2007, Journal of occupational health.

[53]  F. Gonzalez,et al.  Peroxisome Proliferator–Activated Receptor α Protects against Glomerulonephritis Induced by Long-Term Exposure to the Plasticizer Di-(2-Ethylhexyl)Phthalate , 2007 .

[54]  M. Kamijima,et al.  Induction of peroxisome proliferator-activated receptor alpha (PPARα)-related enzymes by di(2-ethylhexyl) phthalate (DEHP) treatment in mice and rats, but not marmosets , 2007, Archives of Toxicology.

[55]  M. Shelby.  NTP-CERHR monograph on the potential human reproductive and developmental effects of di (2-ethylhexyl) phthalate (DEHP). , 2006, NTP CERHR MON.

[56]  Ivan Rusyn,et al.  Modes of Action and Species-Specific Effects of Di-(2-ethylhexyl)Phthalate in the Liver , 2006, Critical reviews in toxicology.

[57]  H. Horiguchi.  P3032 The effect of cadmium exposure to renal function in female Japanese farmers(Poster Presentation,Occupational Health in the Age of Decentralization Reform in Japan,The 79th Annual Meeting of Japan Society for Occupational Health) , 2006 .

[58]  M. Berger,et al.  Lifelong exposure to di-(2-ethylhexyl)-phthalate induces tumors in liver and testes of Sprague-Dawley rats. , 2005, Toxicology.

[59]  K. Takagi,et al.  Species differences in the metabolism of di(2-ethylhexyl) phthalate (DEHP) in several organs of mice, rats, and marmosets , 2005, Archives of Toxicology.

[60]  Benson T Akingbemi,et al.  Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[61]  S. Kersten,et al.  Peroxisome proliferator-activated receptor α target genes , 2004, Cellular and Molecular Life Sciences CMLS.

[62]  J. Huff,et al.  The IARC evaluation of DEHP excludes key papers demonstrating carcinogenic effects. , 2003, International journal of occupational and environmental health.

[63]  R. Melnick.  Suppression of Crucial Information in the IARC Evaluation of DEHP , 2003, International journal of occupational and environmental health.

[64]  R. Melnick.  The IARC Evaluation of Di(2-ethylhexyl)phthalate (DEHP): A Flawed Decision Based on an Untested Hypothesis , 2002, International journal of occupational and environmental health.

[65]  M. Manns,et al.  Developmental aspects of human hepatic drug glucuronidation in young children and adults , 2002, Gut.

[66]  R. Melnick,et al.  Is peroxisome proliferation an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl)phthalate (DEHP)? , 2001, Environmental health perspectives.

[67]  J. Furr,et al.  Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[68]  J. Klaunig,et al.  Effects of di-isononyl phthalate, di-2-ethylhexyl phthalate, and clofibrate in cynomolgus monkeys. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[69]  R. M. David,et al.  Chronic toxicity of di(2-ethylhexyl)phthalate in rats. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[70]  Sander Kersten,et al.  Roles of PPARs in health and disease , 2000, Nature.

[71]  N. Macdonald,et al.  Species differences in response to diethylhexylphthalate: suppression of apoptosis, induction of DNA synthesis and peroxisome proliferator activated receptor alpha-mediated gene expression , 2000, Archives of Toxicology.

[72]  David J. Waxman,et al.  trans-activation of PPARα and PPARγ by structurally diverse environmental chemicals , 1999 .

[73]  B. Lake,et al.  A cancer risk assessment of di(2-ethylhexyl)phthalate: application of the new U.S. EPA Risk Assessment Guidelines. , 1999, Regulatory toxicology and pharmacology : RTP.

[74]  K. Henriksen,et al.  Degradation of Phthalate and Di-(2-Ethylhexyl)phthalate by Indigenous and Inoculated Microorganisms in Sludge-Amended Soil , 1998, Applied and Environmental Microbiology.

[75]  J M Ward,et al.  Receptor and Nonreceptor-Mediated Organ-Specific Toxicity of Di(2-ethylhexyl)phthalate (DEHP) in Peroxisome Proliferator-Activated Receptorα-Null Mice , 1998, Toxicologic pathology.

[76]  J. Peters,et al.  Di(2-ethylhexyl) phthalate induces a functional zinc deficiency during pregnancy and teratogenesis that is independent of peroxisome proliferator-activated receptor-α , 1997 .

[77]  J. Peters,et al.  Di(2-ethylhexyl) phthalate induces a functional zinc deficiency during pregnancy and teratogenesis that is independent of peroxisome proliferator-activated receptor-alpha. , 1997, Teratology.

[78]  J J Heindel,et al.  Di-(2-ethylhexyl) phthalate suppresses estradiol and ovulation in cycling rats. , 1994, Toxicology and applied pharmacology.

[79]  N. Chandar,et al.  DI(2‐ethylhexyl)phthalate‐induced changes in liver estrogen metabolism and hyperplasia , 1994, International journal of cancer.

[80]  E. Berman,et al.  Steroidogenic assessment using ovary culture in cycling rats: effects of bis(2-diethylhexyl)phthalate on ovarian steroid production. , 1993, Reproductive toxicology.

[81]  Caleb Stewart.  Chlorinated drinking-water. , 1981, IARC monographs on the evaluation of carcinogenic risks to humans.

[82]  I. Issemann,et al.  Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators , 1990, Nature.

[83]  P. Albro,et al.  Metabolism of di(2-ethylhexyl)phthalate. , 1989, Drug metabolism reviews.

[84]  C. Kimmel,et al.  Developmental toxicity evaluation of dietary di(2-ethylhexyl)phthalate in Fischer 344 rats and CD-1 mice. , 1988, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[85]  R. Melnick,et al.  Studies By the National Toxicology Program On Di(2-Ethylhexyl)Phthalate , 1987, Toxicology and industrial health.

[86]  J. Teague,et al.  Reproductive effects of four phthalic acid esters in the mouse. , 1987, Toxicology and applied pharmacology.

[87]  P. Albro,et al.  Absorption, metabolism, and excretion of di(2-ethylhexyl) phthalate by rats and mice. , 1986, Environmental health perspectives.

[88]  Thomas Ja,et al.  Biological effects of di-(2-ethylhexyl) phthalate and other phthalic acid esters. , 1984 .

[89]  J. A. Thomas,et al.  Biological effects of di-(2-ethylhexyl) phthalate and other phthalic acid esters. , 1984, Critical reviews in toxicology.

[90]  W. Fritz,et al.  WHO‐IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans. Voi. 29: Some Industrial Chemicals and Dyestuffs. 416 Seiten. International Agency for Research on Cancer, Lyon 1982. Preis: 60,‐ sfrs; 30,– US$ , 1983 .

[91]  P. Albro,et al.  Pharmacokinetics, interactions with macromolecules and species differences in metabolism of DEHP. , 1982, Environmental health perspectives.

[92]  J. F. Douglas,et al.  The carcinogenicity of dietary di(2-ethylhexyl) phthalate (DEHP) in Fischer 344 rats and B6C3F1 mice. , 1982, Journal of toxicology and environmental health.

[93]  Carcinogenesis Bioassay of Di(2-ethylhexyl)phthalate (CAS No. 117-81-7) in F344 Rats and B6C3F1 Mice (Feed Studies). , 1982, National Toxicology Program technical report series.

[94]  R. L. Carter,et al.  IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans , 1980, IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans.