A putative mechanism for downregulation of the catalytic activity of the EGF receptor via direct contact between its kinase and C-terminal domains.

[1]  Sarel J. Fleishman,et al.  A Cα model for the transmembrane α helices of gap junction intercellular channels , 2004 .

[2]  Krystal J Alligood,et al.  A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib) , 2004, Cancer Research.

[3]  C. Heldin,et al.  Autoinhibition of the Platelet-derived Growth Factor β-Receptor Tyrosine Kinase by Its C-terminal Tail* , 2004, Journal of Biological Chemistry.

[4]  Sarel J Fleishman,et al.  An evolutionarily conserved network of amino acids mediates gating in voltage-dependent potassium channels. , 2004, Journal of molecular biology.

[5]  J. Dancey.  Predictive factors for epidermal growth factor receptor inhibitors--the bull's-eye hits the arrow. , 2004, Cancer cell.

[6]  F. Lu,et al.  The structural basis for autoinhibition of FLT3 by the juxtamembrane domain. , 2004, Molecular cell.

[7]  M. Sliwkowski,et al.  An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. , 2003, Molecular cell.

[8]  J. Boerner,et al.  Ligand-independent oncogenic signaling by the epidermal growth factor receptor: v-ErbB as a paradigm. , 2003, Experimental cell research.

[9]  Antony W Burgess,et al.  Epidermal growth factor receptor: mechanisms of activation and signalling. , 2003, Experimental cell research.

[10]  A. M. Stanley,et al.  Structure of the extracellular region of HER 2 alone and in complex with the Herceptin Fab , 2022 .

[11]  Hyun-soo Cho,et al.  EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. , 2003, Molecular cell.

[12]  J. Boerner,et al.  Ligand-independent oncogenic signaling by the epidermal growth factor receptor , 2003 .

[13]  R. Jorissen,et al.  Epidermal growth factor receptor , 2003 .

[14]  Tal Pupko,et al.  Structural Genomics , 2005 .

[15]  Sarel J. Fleishman,et al.  A putative molecular-activation switch in the transmembrane domain of erbB2 , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[16]  M. Sliwkowski,et al.  Structure of the Epidermal Growth Factor Receptor Kinase Domain Alone and in Complex with a 4-Anilinoquinazoline Inhibitor* , 2002, The Journal of Biological Chemistry.

[17]  Jae-Hoon Kim,et al.  Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains , 2002, Cell.

[18]  E. Mekada,et al.  Ligand-independent dimer formation of epidermal growth factor receptor (EGFR) is a step separable from ligand-induced EGFR signaling. , 2002, Molecular biology of the cell.

[19]  Itay Mayrose,et al.  Rate4Site: an algorithmic tool for the identification of functional regions in proteins by surface mapping of evolutionary determinants within their homologues , 2002, ISMB.

[20]  J. Kuriyan,et al.  The Conformational Plasticity of Protein Kinases , 2002, Cell.

[21]  B Honig,et al.  Combining multiple structure and sequence alignments to improve sequence detection and alignment: Application to the SH2 domains of Janus kinases , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[22]  I. Maruyama,et al.  Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain. , 2001, Journal of molecular biology.

[23]  Y. Yarden,et al.  Untangling the ErbB signalling network , 2001, Nature Reviews Molecular Cell Biology.

[24]  A M Hassell,et al.  Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail. , 2000, Structure.

[25]  J. Schlessinger.  Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.

[26]  N. Tennagels,et al.  A single substitution of the insulin receptor kinase inhibits serine autophosphorylation in vitro: evidence for an interaction between the C-terminus and the activation loop. , 2000, Biochemistry.

[27]  R. Norel,et al.  Electrostatic aspects of protein-protein interactions. , 2000, Current opinion in structural biology.

[28]  C. James,et al.  Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. , 2000, Cancer research.

[29]  Tony Hunter,et al.  Receptor signaling: When dimerization is not enough , 1999, Current Biology.

[30]  Alexander Levitzki,et al.  Activation of the Ras/Mitogen-Activated Protein Kinase Pathway by Kinase-Defective Epidermal Growth Factor Receptors Results in Cell Survival but Not Proliferation , 1998, Molecular and Cellular Biology.

[31]  J. Massagué.  TGF-beta signal transduction. , 1998, Annual review of biochemistry.

[32]  E A Merritt,et al.  Raster3D: photorealistic molecular graphics. , 1997, Methods in enzymology.

[33]  S. Jones,et al.  Principles of protein-protein interactions. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[34]  T M Jovin,et al.  Oligomerization of epidermal growth factor receptors on A431 cells studied by time-resolved fluorescence imaging microscopy. A stereochemical model for tyrosine kinase receptor activation , 1995, The Journal of cell biology.

[35]  A. Chantry.  The kinase domain and membrane localization determine intracellular interactions between epidermal growth factor receptors. , 1995, The Journal of biological chemistry.

[36]  H. Kung,et al.  A minor tyrosine phosphorylation site located within the CAIN domain plays a critical role in regulating tissue-specific transformation by erbB kinase , 1995, Journal of virology.

[37]  C. Chan,et al.  The intracellular tyrosine kinase domain of the epidermal growth factor receptor undergoes a conformational change upon autophosphorylation. , 1994, The Journal of biological chemistry.

[38]  J. Schlessinger,et al.  Signaling by Receptor Tyrosine Kinases , 1993 .

[39]  H. L. Robinson,et al.  Characterization of an angiosarcoma-inducing mutation in the erbB oncogene. , 1992, Oncogene.

[40]  M. Shibuya,et al.  A highly conserved tyrosine residue at codon 845 within the kinase domain is not required for the transforming activity of human epidermal growth factor receptor. , 1992, Biochemical and biophysical research communications.

[41]  P. Wedegaertner,et al.  Effect of carboxyl terminal truncation on the tyrosine kinase activity of the epidermal growth factor receptor. , 1992, Archives of biochemistry and biophysics.

[42]  K. Sharp,et al.  Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons , 1991, Proteins.

[43]  P. Kraulis.  A program to produce both detailed and schematic plots of protein structures , 1991 .

[44]  A. Fersht,et al.  Estimating the contribution of engineered surface electrostatic interactions to protein stability by using double-mutant cycles. , 1990, Biochemistry.

[45]  A. Ullrich,et al.  Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation , 1990, Molecular and cellular biology.

[46]  H. Kung,et al.  Disease tropism of c-erbB: effects of carboxyl-terminal tyrosine and internal mutations on tissue-specific transformation. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[47]  H. Kung,et al.  Molecular characterization of three erbB transducing viruses generated during avian leukosis virus-induced erythroleukemia: extensive internal deletion near the kinase domain activates the fibrosarcoma- and hemangioma-inducing potentials of erbB , 1988, Journal of virology.

[48]  A. Ullrich,et al.  A chimeric, ligand-binding v-erbB/EGF receptor retains transforming potential. , 1987, Science.

[49]  Y. Yarden,et al.  Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor. , 1987, Biochemistry.

[50]  H. Robinson,et al.  Differences in sequences encoding the carboxyl-terminal domain of the epidermal growth factor receptor correlate with differences in the disease potential of viral erbB genes. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[51]  M. Das,et al.  Intrapeptide autophosphorylation of the epidermal growth factor receptor: regulation of kinase catalytic function by receptor dimerization. , 1985, Biochemistry.