Three-Dimensional Holographic Electromagnetic Imaging for Accessing Brain Stroke

The authors recently developed a two-dimensional (2D) holographic electromagnetic induction imaging (HEI) for biomedical imaging applications. However, this method was unable to detect small inclusions accurately. For example, only one of two inclusions can be detected in the reconstructed image if the two inclusions were located at the same XY plane but in different Z-directions. This paper provides a theoretical framework of three-dimensional (3D) HEI to accurately and effectively detect inclusions embedded in a biological object. A numerical system, including a realistic head phantom, a 16-element excitation sensor array, a 16-element receiving sensor array, and image processing model has been developed to evaluate the effectiveness of the proposed method for detecting small stroke. The achieved 3D HEI images have been compared with 2D HEI images. Simulation results show that the 3D HEI method can accurately and effectively identify small inclusions even when two inclusions are located at the same XY plane but in different Z-directions. This preliminary study shows that the proposed method has the potential to develop a useful imaging tool for the diagnosis of neurological diseases and injuries in the future.

[1]  Andreas Fhager,et al.  Reconstruction Quality and Spectral Content of an Electromagnetic Time-Domain Inversion Algorithm , 2006, IEEE Transactions on Biomedical Engineering.

[2]  Guobao Wang,et al.  Direct Patlak Reconstruction From Dynamic PET Data Using the Kernel Method With MRI Information Based on Structural Similarity , 2018, IEEE Transactions on Medical Imaging.

[3]  Hermann Scharfetter,et al.  Detection of brain oedema using magnetic induction tomography: a feasibility study of the likely sensitivity and detectability. , 2004, Physiological measurement.

[4]  A Thiagalingam,et al.  A review on electrical impedance tomography for pulmonary perfusion imaging , 2012, Physiological measurement.

[5]  Masaru Ishii,et al.  Non-labeling multiphoton excitation microscopy as a novel diagnostic tool for discriminating normal tissue and colorectal cancer lesions , 2017, Scientific Reports.

[6]  E. Hennessy,et al.  Measurements of gastric emptying during continuous nasogastric infusion of liquid feed: electric impedance tomography versus gamma scintigraphy. , 2006, Clinical nutrition.

[7]  H Griffiths,et al.  Frequency-difference MIT imaging of cerebral haemorrhage with a hemispherical coil array: numerical modelling. , 2010, Physiological measurement.

[8]  Andrea Meyer-Lindenberg,et al.  Electrical impedance tomography for lung ventilation monitoring of the dog , 2017, Tierärztliche Praxis K: Kleintiere/Heimtiere.

[9]  Lulu Wang.  Electromagnetic induction holography imaging for stroke detection. , 2017, Journal of the Optical Society of America. A, Optics, image science, and vision.

[10]  Lulu Wang,et al.  Investigation of Antenna Array Configurations Using Far-Field Holographic Microwave Imaging Technique , 2015 .

[11]  Kyung-Rae Dong,et al.  A study on the dependence of exposure dose reduction and image evaluation on the distance from the dental periapical X-ray machine , 2013 .

[12]  H Griffiths,et al.  Magnetic Induction Tomography: A Measuring System for Biological Tissues , 1999, Annals of the New York Academy of Sciences.

[13]  Ruigang Liu,et al.  Preliminary research on monitoring of cerebral ischemia using electrical impedance tomography technique , 2008, 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[14]  A. S. Daryoush,et al.  Near field microwave brain imaging , 2001 .

[15]  N. H. Saunders,et al.  A feasibility study of in vivo electromagnetic imaging. , 1993, Physics in medicine and biology.

[16]  A Korjenevsky,et al.  Magnetic induction tomography: experimental realization. , 2000, Physiological measurement.

[17]  Richard Bayford,et al.  Bioimpedance imaging: an overview of potential clinical applications. , 2012, The Analyst.

[18]  Amir Leshem,et al.  Synthetic aperture radio telescopes , 2010, IEEE Signal Processing Magazine.

[19]  Joanna M. Wardlaw,et al.  MRI Versus CT for Detection of Acute Vascular Lesions in Patients Presenting With Stroke Symptoms , 2010 .

[20]  R. Merwa,et al.  Numerical simulation of the eddy current problem in magnetic induction tomography for biomedical applications by edge elements , 2004, IEEE Transactions on Magnetics.

[21]  Lulu Wang,et al.  Imaging of 3-D Dielectric Objects Using Far-Field Holographic Microwave Imaging Technique , 2014 .

[22]  Bing Li,et al.  In Vivo Imaging of Twist Drill Drainage for Subdural Hematoma: A Clinical Feasibility Study on Electrical Impedance Tomography for Measuring Intracranial Bleeding in Humans , 2013, PloS one.

[23]  Patricia Brunner,et al.  Reconstruction of the shape of conductivity spectra using differential multi-frequency magnetic induction tomography , 2006, Physiological measurement.

[24]  Thomas C. Ferrée,et al.  Weighted regularization in electrical impedance tomography with applications to acute cerebral stroke , 2002, IEEE Transactions on Medical Imaging.

[25]  Takashi Takenaka,et al.  Two-Dimensional Time-Domain Inverse Scattering for Quantitative Analysis of Breast Composition , 2008, IEEE Transactions on Biomedical Engineering.

[26]  Lulu Wang,et al.  Imaging of Lung Structure Using Holographic Electromagnetic Induction , 2017, IEEE Access.

[27]  Ernst Klotz,et al.  Angiographic Reconstructions From Whole-Brain Perfusion CT for the Detection of Large Vessel Occlusion in Acute Stroke , 2012, Stroke.

[28]  Amin M. Abbosh,et al.  Microwave imaging for brain stroke detection using Born iterative method , 2013 .

[29]  M. Schmid.  Principles Of Optics Electromagnetic Theory Of Propagation Interference And Diffraction Of Light , 2016 .

[30]  F A Wali,et al.  Effect of electromagnetic induction on impulse conduction in the frog nerve-muscle preparation. , 1989, Biochemical Society transactions.

[31]  Mehrnoosh Akhtari-Zavare,et al.  Electrical Impedance Tomography as a Primary Screening Technique for Breast Cancer Detection. , 2015, Asian Pacific journal of cancer prevention : APJCP.

[32]  Yang Liu,et al.  A feasibility study of magnetic resonance electrical impedance tomography for prostate cancer detection , 2014, Physiological measurement.

[33]  Feng Dong,et al.  Multi-frequency difference method for intracranial hemorrhage detection by magnetic induction tomography , 2018, Physiological measurement.

[34]  Lluis Jofre,et al.  Active microwave computed brain tomography: The response to a challenge , 1991, Journal of Neuroscience Methods.

[35]  Bing Li,et al.  Use of Electrical Impedance Tomography to Monitor Regional Cerebral Edema during Clinical Dehydration Treatment , 2014, PloS one.

[36]  N. M. Zain,et al.  Study of Electrical Impedance Tomography as a primary screening technique for breast cancer , 2014, 2014 IEEE Conference on Biomedical Engineering and Sciences (IECBES).

[37]  H Griffiths,et al.  A magnetic induction tomography system for samples with conductivities below 10 S m−1 , 2008 .