Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1

[1]  D. Gutmann,et al.  Developmental regulation of a neuron‐specific neurofibromatosis 1 isoform , 1999, Annals of neurology.

[2]  S. Ozonoff,et al.  Cognitive impairment in neurofibromatosis type 1. , 1999, American journal of medical genetics.

[3]  M. Nordlund,et al.  Region-specific astrogliosis in brains of mice heterozygous for mutations in the neurofibromatosis type 1 (Nf1) tumor suppressor , 1999, Brain Research.

[4]  Alcino J. Silva,et al.  Ibotenate lesions of the hippocampus impair spatial learning but not contextual fear conditioning in mice , 1998, Behavioural Brain Research.

[5]  J. Kogan,et al.  A mouse model for learning and memory defects associated with neurofibromatosis type I. , 1998, Pathologie-biologie.

[6]  J. David Sweatt,et al.  The MAPK cascade is required for mammalian associative learning , 1998, Nature Neuroscience.

[7]  Y. Shim.  Gene Structure and Function , 1998 .

[8]  A. Wittinghofer,et al.  Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1. , 1998, Human molecular genetics.

[9]  Alcino J. Silva,et al.  The dorsal hippocampus is essential for context discrimination but not for contextual conditioning. , 1998, Behavioral neuroscience.

[10]  D. Cooper,et al.  Neurofibromatosis Type 1:: From Genotype to Phenotype , 1998 .

[11]  S. Grant,et al.  A role for the Ras signalling pathway in synaptic transmission and long-term memory , 1997, Nature.

[12]  Richard Paylor,et al.  Social Interaction and Sensorimotor Gating Abnormalities in Mice Lacking Dvl1 , 1997, Cell.

[13]  Paul W. Frankland,et al.  A mouse model for the learning and memory deficits associated with neurofibromatosis type I , 1997, Nature Genetics.

[14]  Alcino J. Silva,et al.  Spaced training induces normal long-term memory in CREB mutant mice , 1997, Current Biology.

[15]  G. Skuse,et al.  NF1 mRNA isoform expression in PC12 cells: modulation by extrinsic factors. , 1996, Experimental cell research.

[16]  Francis Collins,et al.  Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia , 1996, Cell.

[17]  T. Jacks,et al.  Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells , 1996, Nature Genetics.

[18]  D. Largaespada,et al.  Nf1 deficiency causes Ras-Dediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia , 1996, Nature Genetics.

[19]  Richard F. Thompson,et al.  Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKCγ mutant mice , 1995, Cell.

[20]  K. Thomas,et al.  A mouse model for the delta F508 allele of cystic fibrosis. , 1995, The Journal of clinical investigation.

[21]  M. Nordlund,et al.  Neurofibromin Expression and Astrogliosis in Neurofibromatosis (Type 1) Brains , 1995, Journal of neuropathology and experimental neurology.

[22]  Alcino J. Silva,et al.  Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein , 1994, Cell.

[23]  Alastair Compston,et al.  The Neurofibromatoses. A pathogenetic and clinical overview , 1994 .

[24]  Robert A. Weinberg,et al.  Tumour predisposition in mice heterozygous for a targeted mutation in Nf1 , 1994, Nature Genetics.

[25]  N. Copeland,et al.  Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. , 1994, Genes & development.

[26]  S. Pulst,et al.  Differential expression and tissue distribution of type I and type II neurofibromins during mouse fetal development. , 1994, Developmental biology.

[27]  P. Swiatek,et al.  Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. , 1993, Genes & development.

[28]  M. Wigler,et al.  A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity , 1993, Molecular and cellular biology.

[29]  M. Rudnicki,et al.  Simplified mammalian DNA isolation procedure. , 1991, Nucleic acids research.

[30]  M. Wigler,et al.  The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins , 1990, Cell.

[31]  F. Tamanoi,et al.  The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae , 1990, Cell.

[32]  P. O’Connell,et al.  The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21 , 1990, Cell.

[33]  S. Yehuda,et al.  The use of the Morris Water Maze in the study of memory and learning. , 1989, The International journal of neuroscience.

[34]  V. M. Riccardi,et al.  Von Recklinghausen neurofibromatosis. , 1981, The New England journal of medicine.

[35]  F. Collins,et al.  Expression of the neurofibromatosis type 1 (NF1) gene during mouse embryonic development. , 1995, Progress in brain research.

[36]  H Eichenbaum,et al.  Selective damage to the hippocampal region blocks long‐term retention of a natural and nonspatial stimulus‐stimulus association , 1995, Hippocampus.

[37]  E. Robertson.  Teratocarcinomas and embryonic stem cells : a practical approach , 1987 .

[38]  B. Hogan,et al.  Manipulating the mouse embryo: A laboratory manual , 1986 .