Does Paget's disease exist in India?: A series of 21 patients.

OBJECTIVE Paget's disease of bone has been described as a few case reports from India. The aim of the present study is to document the existence of Paget's disease (PD) in India. MATERIAL AND METHODS We describe demography, clinical manifestations, biochemical and radiological profile and the treatment outcome of 21 patients of PD. RESULTS Mean (+/-SD) age of these patients at presentation was 49.2 +/- 17.6 years and the male to female ratio was 2.5:1. Common clinical manifestations included backache, headache and bone pains. Others were fracture, joint pain, deafness, gait ataxia, visual impairment and difficulty in biting. Two patients presented with hydrocephalus and one had recurrent paraparesis. Fifteen (71.4%) patients had polyostotic and six (28.6%) had monoostotic Paget's disease. More commonly involved bones were skull and spine (61.9%) followed by pelvis (38.1%), femur (33.3%), tibia (9%) and ulna (9%). Mean (+/-SD) serum alkaline phosphatase at diagnosis was 1514 +/- 1168 IU/L and nine months after treatment with bisphosphonates decreased to 454 +/- 406 IU/ L(P<0.03). CONCLUSION This illustrates that Paget's disease does exist in India and a high index of suspicion is required to clinch the diagnosis.

[1]  V. Ramesh,et al.  Vertex extradural hematoma in association with Paget's disease of the skull. , 2005, Neurology India.

[2]  Yuk-Kwan Chen,et al.  Paget's disease of bone in a Chinese patient: a case report and review of the literature. , 2005, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[3]  G. Gamble,et al.  Paget’s Disease of Bone in New Zealand: Continued Decline in Disease Severity , 2004, Calcified Tissue International.

[4]  E. Monsell.  The Mechanism of Hearing Loss in Paget's Disease of Bone , 2004, The Laryngoscope.

[5]  O. ÓscarContreras,et al.  Enfermedad de Paget en Chile: una serie de 15 pacientes , 2003 .

[6]  A. Saifuddin,et al.  Paget's disease of the spine: unusual features and complications. , 2003, Clinical radiology.

[7]  S. Jacobelli,et al.  [Paget disease of bone in Chile: report of 15 cases]. , 2003, Revista medica de Chile.

[8]  J. Windle,et al.  Paget disease of bone. , 2005, Radiographics : a review publication of the Radiological Society of North America, Inc.

[9]  Jordi Carbonell,et al.  Enfermedad ósea de Paget: estudio de 314 pacientes , 2002 .

[10]  A. Olivé,et al.  [Paget's disease of bone: study of 314 patients]. , 2002, Medicina clinica.

[11]  J. Tucci,et al.  Intravenously administered pamidronate in the treatment of Paget's disease of bone. , 2001, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[12]  J. Kanis,et al.  Atypical familial Paget's disease of bone. , 2001, Joint, bone, spine : revue du rhumatisme.

[13]  F. Singer,et al.  Genetics of endocrine disease: The genetics of paget's disease of the bone , 2001 .

[14]  F. Singer,et al.  The Genetics of Paget’s Disease of the Bone , 2001 .

[15]  H. Gruber,et al.  Thirty Cases of Concurrent Paget's Disease and Primary Hyperparathyroidism: Sex Distribution, Histomorphometry, and Prediction of the Skeletal Response to Parathyroidectomy , 1999, Calcified Tissue International.

[16]  A. Poncelet.  The neurologic complications of paget's disease , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[17]  M. Hansen,et al.  Common mechanisms of osteosarcoma and paget's disease , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[18]  P. Delmas,et al.  MANAGEMENT OF PAGET’S DISEASE OF BONE , 1978 .

[19]  H. Schuknecht,et al.  In search of pathologic correlates for hearing loss and vertigo in Paget's disease. A clinical and histopathologic study of 26 temporal bones. , 1990, The Annals of otology, rhinology & laryngology. Supplement.

[20]  K. Kumar.  Paget's disease of bone. , 1986, Calcified tissue international.

[21]  A. Emery,et al.  A family study of Paget's disease of bone. , 1983, Journal of epidemiology and community health.

[22]  A. Emery,et al.  A family study ofPaget's disease ofbone , 1983 .

[23]  J. Kanis,et al.  Spinal cord dysfunction in Paget's disease of bone. Has medical treatment a vascular basis? , 1981, The Journal of bone and joint surgery. British volume.

[24]  N. Chakravorty.  Triradiate deformity of the pelvis in Paget's disease of bone. , 1980, Postgraduate medical journal.

[25]  D H COLLINS,et al.  PAGET'S DISEASE OF BONE: INCIDENCE AND SUBCLINICAL FORMS , 1956 .