Rutin attenuates H2O2-induced oxidation damage and apoptosis in Leydig cells by activating PI3K/Akt signal pathways.

[1]  B. Guo,et al.  Protective Effect of Rutin Against H2O2-Induced Oxidative Stress and Apoptosis in Human Lens Epithelial Cells , 2016, Current eye research.

[2]  Jiaxiang Chen,et al.  Involvement of oxidative stress in tri-ortho–cresyl phosphate-induced autophagy of mouse Leydig TM3 cells in vitro , 2016, Reproductive Biology and Endocrinology.

[3]  Haitian Ma,et al.  Dehydroepiandrosterone ameliorates H2O2-induced Leydig cells oxidation damage and apoptosis through inhibition of ROS production and activation of PI3K/Akt pathways. , 2016, The international journal of biochemistry & cell biology.

[4]  Sunil Kumar,et al.  Role of Oxidative Stress in Male Reproductive Dysfunctions with Reference to Phthalate Compounds. , 2015, Urology journal.

[5]  I. Huhtaniemi,et al.  Morphological and functional maturation of Leydig cells: from rodent models to primates. , 2015, Human reproduction update.

[6]  Ashok Agarwal,et al.  A unique view on male infertility around the globe , 2015, Reproductive Biology and Endocrinology.

[7]  Ram B Singh,et al.  Coenzyme Q10, α-Tocopherol, and Oxidative Stress Could Be Important Metabolic Biomarkers of Male Infertility , 2015, Disease markers.

[8]  R. Ge,et al.  Basic fibroblast growth factor promotes stem Leydig cell development and inhibits LH-stimulated androgen production by regulating microRNA expression , 2014, The Journal of Steroid Biochemistry and Molecular Biology.

[9]  S. Hekimi,et al.  The Intrinsic Apoptosis Pathway Mediates the Pro-Longevity Response to Mitochondrial ROS in C. elegans , 2014, Cell.

[10]  L. S. Chua A review on plant-based rutin extraction methods and its pharmacological activities. , 2013, Journal of ethnopharmacology.

[11]  J. Słowikowska-Hilczer,et al.  The role of oxidative stress and antioxidants in male fertility , 2013, Central European journal of urology.

[12]  Guo Ji-me Advances in Causes and Treatment of Male Infertility , 2013 .

[13]  F. H. Mollah,et al.  Effect of oxidative stress in male infertility. , 2013, Mymensingh Medical Journal.

[14]  Seth R. Flaxman,et al.  National, Regional, and Global Trends in Infertility Prevalence Since 1990: A Systematic Analysis of 277 Health Surveys , 2012, PLoS medicine.

[15]  Aleksander Giwercman,et al.  European Association of Urology guidelines on Male Infertility: the 2012 update. , 2012, European urology.

[16]  Wei Wu,et al.  Methylenetetrahydrofolate reductase C677T polymorphism and the risk of male infertility: a meta-analysis. , 2012, International journal of andrology.

[17]  K. Yeum,et al.  Lutein and zeaxanthin supplementation reduces H2O2-induced oxidative damage in human lens epithelial cells , 2011, Molecular vision.

[18]  A. Frigo,et al.  Toward a pharmacogenetic approach to male infertility: polymorphism of follicle-stimulating hormone beta-subunit promoter. , 2011, Fertility and sterility.

[19]  A. Agarwal,et al.  Epigenetics, spermatogenesis and male infertility. , 2011, Mutation research.

[20]  K. Tremellen,et al.  Impact of body mass index on seminal oxidative stress , 2011, Andrologia.

[21]  A. Coomarasamy,et al.  A systematic review of the effect of oral antioxidants on male infertility. , 2010, Reproductive biomedicine online.

[22]  Guohua Gong,et al.  Rutin inhibits hydrogen peroxide-induced apoptosis through regulating reactive oxygen species mediated mitochondrial dysfunction pathway in human umbilical vein endothelial cells. , 2010, European journal of pharmacology.

[23]  Jae Heun Lee,et al.  Rutin from Lonicera japonica inhibits myocardial ischemia/reperfusion-induced apoptosis in vivo and protects H9c2 cells against hydrogen peroxide-mediated injury via ERK1/2 and PI3K/Akt signals in vitro. , 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[24]  J. Oh,et al.  Cytoprotective effects of Morinda officinalis against hydrogen peroxide-induced oxidative stress in Leydig TM3 cells. , 2008, Asian journal of andrology.

[25]  W. Wätjen,et al.  Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans. , 2007, Toxicology.

[26]  J. Sánchez-Yagüe,et al.  Membrane cholesterol contents influence the protective effects of quercetin and rutin in erythrocytes damaged by oxidative stress. , 2006, Chemico-biological interactions.

[27]  N. Seyhan,et al.  In Vivo Effects of ELF MFs on Collagen Synthesis, Free Radical Processes, Natural Antioxidant System, Respiratory Burst System, Immune System Activities, and Electrolytes in the Skin, Plasma, Spleen, Lung, Kidney, and Brain Tissues , 2006, Electromagnetic biology and medicine.

[28]  D. Gautam,et al.  H2O2 at physiological concentrations modulates Leydig cell function inducing oxidative stress and apoptosis , 2006, Apoptosis.

[29]  G. Thomas,et al.  Lipid peroxidation and the thiobarbituric acid assay: standardization of the assay when using saturated and unsaturated fatty acids. , 2004, Journal of biochemistry and molecular biology.

[30]  David Handelsman,et al.  Sertoli and germ cell development in hypogonadal (hpg) mice expressing transgenic follicle-stimulating hormone alone or in combination with testosterone. , 2003, Endocrinology.

[31]  A. Jungwirth,et al.  EAU guidelines on male infertility. , 2002, European urology.

[32]  C. Shaha,et al.  Role of glutathione S-transferases in oxidative stress-induced male germ cell apoptosis. , 2000, Free radical biology & medicine.

[33]  B. Buszewski,et al.  Simultaneous isolation of Rutin and Esculin from plant material and drugs using solid-phase extraction. , 1993, Journal of pharmaceutical and biomedical analysis.

[34]  L. Johnson,et al.  Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. , 1984, The Journal of clinical endocrinology and metabolism.