Association Between Maternal Caffeine Consumption and Metabolism and Neonatal Anthropometry

Key Points Question Is maternal caffeine intake associated with neonatal anthropometry? Findings In this cohort study of 2055 women from 12 clinical sites, measures of caffeine consumption (plasma caffeine and paraxanthine and self-reported consumption) were associated with neonatal size at birth. Increasing caffeine measures were significantly associated with lower birth weight, shorter length, and smaller head, arm, and thigh circumference. Meaning In this study, caffeine consumption during pregnancy, even in amounts less than the recommended 200 mg per day, was associated with smaller neonatal anthropometric measurements.

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