MaizeGDB 2018: the maize multi-genome genetics and genomics database

Abstract Since its 2015 update, MaizeGDB, the Maize Genetics and Genomics database, has expanded to support the sequenced genomes of many maize inbred lines in addition to the B73 reference genome assembly. Curation and development efforts have targeted high quality datasets and tools to support maize trait analysis, germplasm analysis, genetic studies, and breeding. MaizeGDB hosts a wide range of data including recent support of new data types including genome metadata, RNA-seq, proteomics, synteny, and large-scale diversity. To improve access and visualization of data types several new tools have been implemented to: access large-scale maize diversity data (SNPversity), download and compare gene expression data (qTeller), visualize pedigree data (Pedigree Viewer), link genes with phenotype images (MaizeDIG), and enable flexible user-specified queries to the MaizeGDB database (MaizeMine). MaizeGDB also continues to be the community hub for maize research, coordinating activities and providing technical support to the maize research community. Here we report the changes MaizeGDB has made within the last three years to keep pace with recent software and research advances, as well as the pan-genomic landscape that cheaper and better sequencing technologies have made possible. MaizeGDB is accessible online at https://www.maizegdb.org.

[1]  Lisa C. Harper,et al.  Surveying the Maize community for their diversity and pedigree visualization needs to prioritize tool development and curation , 2017, Database J. Biol. Databases Curation.

[2]  Stephen P. Ficklin,et al.  AgBioData consortium recommendations for sustainable genomics and genetics databases for agriculture , 2018, Database J. Biol. Databases Curation.

[3]  M. McMullen,et al.  Genetic Design and Statistical Power of Nested Association Mapping in Maize , 2008, Genetics.

[4]  Peter D. Karp,et al.  Pathway Tools version 13.0: integrated software for pathway/genome informatics and systems biology , 2015, Briefings Bioinform..

[5]  John Quackenbush,et al.  POPcorn: An Online Resource Providing Access to Distributed and Diverse Maize Project Data , 2011, International journal of plant genomics.

[6]  W. Williams,et al.  Characterization of the Maize Chitinase Genes and Their Effect on Aspergillus flavus and Aflatoxin Accumulation Resistance , 2015, PloS one.

[7]  Maureen C. McCann,et al.  Genetic Resources for Maize Cell Wall Biology1[C][W][OA] , 2009, Plant Physiology.

[8]  N. Carpita,et al.  Maize and sorghum: genetic resources for bioenergy grasses. , 2008, Trends in plant science.

[9]  Lisa C. Harper,et al.  Choosing a genome browser for a Model Organism Database: surveying the Maize community , 2010, Database J. Biol. Databases Curation.

[10]  Julie A. Dickerson,et al.  The quality of metabolic pathway resources depends on initial enzymatic function assignments: a case for maize , 2016, BMC Systems Biology.

[11]  Robert J. Elshire,et al.  Comprehensive genotyping of the USA national maize inbred seed bank , 2013, Genome Biology.

[12]  James C. Schnable,et al.  Integration of omic networks in a developmental atlas of maize , 2016, Science.

[13]  G. Beadle,et al.  The Relation of Crossing over to Chromosome Association in Zea-Euchlaena Hybrids. , 1932, Genetics.

[14]  Taner Z. Sen,et al.  SNPversity: a web-based tool for visualizing diversity , 2018, Database J. Biol. Databases Curation.

[15]  L. Stadler,et al.  Genetic Effects of X-Rays in Maize. , 1928, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Iain S. Donnison,et al.  Identification of genes involved in cell wall biogenesis in grasses by differential gene expression profiling of elongating and non-elongating maize internodes , 2011, Journal of experimental botany.

[17]  Qunfeng Dong,et al.  MaizeGDB, the community database for maize genetics and genomics , 2004, Nucleic Acids Res..

[18]  Lisa C. Harper,et al.  MaizeGDB's new data types, resources and activities , 2007, Nucleic Acids Res..

[19]  M. Rhoades,et al.  The early years of maize genetics. , 1984, Annual review of genetics.

[20]  G. Shull The composition of a field of maize , 1908 .

[21]  Iddo Friedberg,et al.  Biological Database of Images and Genomes: tools for community annotations linking image and genomic information , 2013, Database J. Biol. Databases Curation.

[22]  Jack Gardiner,et al.  MaizeGDB: The Maize Genetics and Genomics Database. , 2016, Methods in molecular biology.

[23]  Kevin L. Childs,et al.  Draft Assembly of Elite Inbred Line PH207 Provides Insights into Genomic and Transcriptome Diversity in Maize[OPEN] , 2016, Plant Cell.

[24]  Carolyn J. Lawrence,et al.  MaizeGDB: The Maize Model Organism Database for Basic, Translational, and Applied Research , 2008, International journal of plant genomics.

[25]  Seung Y. Rhee,et al.  Genomic Signatures of Specialized Metabolism in Plants , 2014, Science.

[26]  Sergio Contrino,et al.  InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data , 2012, Bioinform..

[27]  Jianbing Yan,et al.  Contributions of Zea mays subspecies mexicana haplotypes to modern maize , 2017, Nature Communications.

[28]  Peter J. Bradbury,et al.  High-resolution genetic mapping of maize pan-genome sequence anchors , 2015, Nature Communications.

[29]  Steven B. Cannon,et al.  Chromosome Visualization Tool: A Whole Genome Viewer , 2011, International journal of plant genomics.

[30]  Robert J. Elshire,et al.  A First-Generation Haplotype Map of Maize , 2009, Science.

[31]  E. Myers,et al.  Basic local alignment search tool. , 1990, Journal of molecular biology.

[32]  Peter D. Karp,et al.  Pathway Tools version 19.0 update: software for pathway/genome informatics and systems biology , 2016, Briefings Bioinform..

[33]  Volker Brendel,et al.  MaizeGDB becomes ‘sequence-centric’ , 2009, Database J. Biol. Databases Curation.

[34]  Lisa C. Harper,et al.  MaizeGDB update: new tools, data and interface for the maize model organism database , 2015, Nucleic Acids Res..

[35]  P. Schnable,et al.  Extensive intraspecific gene order and gene structural variations between Mo17 and other maize genomes , 2018, Nature Genetics.

[36]  Josh Strable,et al.  Maize (Zea mays): a model organism for basic and applied research in plant biology. , 2009, Cold Spring Harbor protocols.

[37]  M. Freeling,et al.  How to usefully compare homologous plant genes and chromosomes as DNA sequences. , 2008, The Plant journal : for cell and molecular biology.

[38]  Lincoln Stein,et al.  Using GBrowse 2.0 to visualize and share next-generation sequence data , 2013, Briefings Bioinform..

[39]  Hector Sanchez-Villeda,et al.  MaizeDB – A Functional Genomics Perspective , 2002, Comparative and functional genomics.

[40]  H. Creighton,et al.  A Correlation of Cytological and Genetical Crossing-Over in Zea Mays. , 1931, Proceedings of the National Academy of Sciences of the United States of America.

[41]  R. Sekhon,et al.  An Expanded Maize Gene Expression Atlas based on RNA Sequencing and its Use to Explore Root Development , 2016, The plant genome.

[42]  Jianbing Yan,et al.  KRN4 Controls Quantitative Variation in Maize Kernel Row Number , 2015, PLoS genetics.

[43]  Daniel L. Vera,et al.  The maize W22 genome provides a foundation for functional genomics and transposon biology , 2018, Nature Genetics.

[44]  Virginia Walbot,et al.  Translational Genomics for Bioenergy Production from Fuelstock Grasses: Maize as the Model Species , 2007, The Plant Cell Online.