The expression of stem cell factor and c‐kit receptor in human asthmatic airways

Background Asthmatic airways are characterized by infiltration with a variety of inflammatory cells such as mast cells and eosinophils. Stem cell factor (SCF) is an important activating and chemotactic factor for both mast cells and eosinophils. In addition, it is a critical growth and differentiation factor for mast cells.

[1]  D. Taub,et al.  Stem cell factor induces eosinophil activation and degranulation: mediator release and gene array analysis. , 2002, Blood.

[2]  D. Metcalf,et al.  Stem Cell Factor Can Stimulate the Formation of Eosinophils by Two Types of Murine Eosinophil Progenitor Cells , 2002, Stem cells.

[3]  I. Pavord,et al.  Mast-cell infiltration of airway smooth muscle in asthma. , 2002, The New England journal of medicine.

[4]  T. Ishizuka,et al.  Sensitized Mast Cells Migrate Toward the Agen: A Response Regulated by p38 Mitogen-Activated Protein Kinase and Rho-Associated Coiled-Coil-Forming Protein Kinase1 , 2001, The Journal of Immunology.

[5]  F. Levi-Schaffer,et al.  Human peripheral blood eosinophils express stem cell factor. , 2001, Blood.

[6]  M. Neurath,et al.  Local administration of antisense phosphorothioate oligonucleotides to the c-kit ligand, stem cell factor, suppresses airway inflammation and IL-4 production in a murine model of asthma. , 2001, The Journal of allergy and clinical immunology.

[7]  S. Galli,et al.  Mast Cells Can Amplify Airway Reactivity and Features of Chronic Inflammation in an Asthma Model in Mice , 2000, The Journal of experimental medicine.

[8]  Jansen,et al.  Lung epithelial H292 cells induce differentiation of immature human HMC‐1 mast cells by interleukin‐6 and stem cell factor , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[9]  Xuliang Jiang,et al.  Structure of the active core of human stem cell factor and analysis of binding to its receptor Kit , 2000, The EMBO journal.

[10]  G. Nilsson,et al.  Demonstration of mast cell chemotactic activity in bronchoalveolar lavage fluid collected from asthmatic patients before and during pollen season. , 2000, The Journal of allergy and clinical immunology.

[11]  D. C. Cara,et al.  Stem Cell Factor Plays a Major Role in the Recruitment of Eosinophils in Allergic Pleurisy in Mice Via the Production of Leukotriene B4 , 2000 .

[12]  T. Zuberbier,et al.  Mast cell and myeloid marker expression during early in vitro mast cell differentiation from human peripheral blood mononuclear cells. , 2000, The Journal of investigative dermatology.

[13]  C. Hogaboam,et al.  Stem cell factor-induced airway hyperreactivity in allergic and normal mice. , 1999, The American journal of pathology.

[14]  N. Frossard,et al.  Up- and down-regulation by glucocorticoids of the constitutive expression of the mast cell growth factor stem cell factor by human lung fibroblasts in culture. , 1998, Molecular pharmacology.

[15]  R. Takizawa,et al.  Stem cell factor mRNA expression and production in human nasal epithelial cells: contribution to the accumulation of mast cells in the nasal epithelium of allergy. , 1998, The Journal of allergy and clinical immunology.

[16]  S. Holgate,et al.  Human mast cells express stem cell factor , 1998, The Journal of pathology.

[17]  J. Denburg,et al.  Stem cell factor in nasal polyposis and allergic rhinitis: increased expression by structural cells is suppressed by in vivo topical corticosteroids. , 1997, The Journal of allergy and clinical immunology.

[18]  D. Olivieri,et al.  Does the mast cell still have a key role in asthma? , 1997, Chest.

[19]  M. Heidtman,et al.  Human Peripheral Blood Eosinophils Express a Functional c-kit Receptor for Stem Cell Factor that Stimulates Very Late Antigen 4 (VLA-4)–mediated Cell Adhesion to Fibronectin and Vascular Cell Adhesion Molecule 1 (VCAM-1) , 1997, The Journal of experimental medicine.

[20]  D. Metcalfe,et al.  Glucocorticoids decrease tissue mast cell number by reducing the production of the c-kit ligand, stem cell factor, by resident cells: in vitro and in vivo evidence in murine systems. , 1997, The Journal of clinical investigation.

[21]  G. Rosen,et al.  Airway epithelial cells produce stem cell factor. , 1996, Biochimica et biophysica acta.

[22]  P. Howarth,et al.  CYTOKINE PRODUCTION BY CELL CULTURES FROM BRONCHIAL SUBEPITHELIAL MYOFIBROBLASTS , 1996, The Journal of pathology.

[23]  D. Taub,et al.  Stem cell factor (c-kit ligand) influences eosinophil recruitment and histamine levels in allergic airway inflammation. , 1996, Journal of immunology.

[24]  D. Taub,et al.  The role of stem cell factor (c-kit ligand) and inflammatory cytokines in pulmonary mast cell activation. , 1996, Blood.

[25]  P. Bradding.  Human mast cell cytokines , 1996, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[26]  S. Holgate,et al.  IgE-dependent expression of mRNA for IL-4 and IL-5 in human lung mast cells. , 1995, Journal of immunology.

[27]  R. Egan,et al.  Mast cells modulate allergic pulmonary eosinophilia in mice. , 1995, American journal of respiratory cell and molecular biology.

[28]  F. Mills,et al.  Activated mast cells produce interleukin 13 , 1995, The Journal of experimental medicine.

[29]  B. Make,et al.  Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. American Thoracic Society. , 1995, American journal of respiratory and critical care medicine.

[30]  S. Wasserman,et al.  Mast cells and airway inflammation in asthma. , 1994, American journal of respiratory and critical care medicine.

[31]  G. Nilsson,et al.  Stem cell factor is a chemotactic factor for human mast cells. , 1994, Journal of immunology.

[32]  V. Broudy,et al.  Human umbilical vein endothelial cells display high-affinity c-kit receptors and produce a soluble form of the c-kit receptor. , 1994, Blood.

[33]  D. Metcalfe,et al.  IL-3-dependent murine mast cells undergo apoptosis on removal of IL-3. Prevention of apoptosis by c-kit ligand. , 1993, Journal of immunology.

[34]  K. Ohta,et al.  Stem cell factor has histamine releasing activity in rat connective tissue-type mast cells. , 1992, Biochemical and Biophysical Research Communications - BBRC.

[35]  K. Zsebo,et al.  Effect of IL-3 and stem cell factor on the appearance of human basophils and mast cells from CD34+ pluripotent progenitor cells. , 1992, Journal of immunology.

[36]  R. Hoffman,et al.  Role of c-kit ligand in the expansion of human hematopoietic progenitor cells. , 1992, Blood.

[37]  S. Nishikawa,et al.  Necessity of extracellular domain of W (c-kit) receptors for attachment of murine cultured mast cells to fibroblasts. , 1992, Blood.

[38]  S. Bischoff,et al.  c-kit ligand: a unique potentiator of mediator release by human lung mast cells , 1992, The Journal of experimental medicine.

[39]  J. Abrams,et al.  Human eosinophils synthesize and secrete interleukin-6, in vitro. , 1992, Blood.

[40]  S. Durham,et al.  Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. , 1991, The Journal of allergy and clinical immunology.

[41]  C. Croce,et al.  Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24. , 1991, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[42]  E. Bleecker,et al.  Immediate and late inflammatory responses to ragweed antigen challenge of the peripheral airways in allergic asthmatics. Cellular, mediator, and permeability changes. , 1991, The American review of respiratory disease.

[43]  A. B. Kay,et al.  Asthma and inflammation. , 1991, The Journal of allergy and clinical immunology.

[44]  D. Williams,et al.  The effect of recombinant mast cell growth factor on purified murine hematopoietic stem cells , 1991, The Journal of experimental medicine.

[45]  P. Leder,et al.  Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant , 1991, Cell.

[46]  W. Paul,et al.  Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores , 1989, Nature.

[47]  W. Paul,et al.  Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores. , 1989, Nature.

[48]  A. Kay,et al.  The relationship between infiltrating CD4+ lymphocytes, activated eosinophils, and the magnitude of the allergen-induced late phase cutaneous reaction in man. , 1988, Journal of immunology.

[49]  S. Wenzel,et al.  Activation of pulmonary mast cells by bronchoalveolar allergen challenge. In vivo release of histamine and tryptase in atopic subjects with and without asthma. , 1988, The American review of respiratory disease.

[50]  J. Dixon,et al.  Localization of atrial natriuretic peptide mRNA and immunoreactivity in the rat heart and human atrial appendage. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[51]  P. Frith,et al.  Determinants of allergen-induced asthma: dose of allergen, circulating IgE antibody concentration, and bronchial responsiveness to inhaled histamine. , 1979, The American review of respiratory disease.