T cell function in children with acute lymphoblastic leukaemia

Summary. Modern intensive chemotherapy has dramatically improved the prognosis of acute lymphoblastic leukaemia (ALL) in children. However, once remission has been established, quality of life and even survival may be threatened by exacerbation of viral infections in the prolonged period of continuation therapy necessary to prevent relapse. Often the viruses involved in the most severe infections are from the herpesvirus and paramyxovirus groups, suggesting that patients suffer from a defect in the cellular immunity thought essential to control such cell‐associated infections. This may result from a T cell defect and, in this study, T cell responsiveness of patients under therapy for leukaemia has been investigated.

[1]  S. Richards,et al.  MRC UKALL X. The UK protocol for childhood ALL: 1985-1990. The Medical Research Council Working Party on Childhood Leukaemia. , 1992, Leukemia.

[2]  J. Peto,et al.  Results of Medical Research Council Childhood Leukaemia Trial UKALL VIII (Report to the Medical Research Council on behalf of the Working Party on Leukaemia in Childhood) , 1991, British journal of haematology.

[3]  R. Millman,et al.  Local antibody production and respiratory syncytial virus infection in children with leukaemia , 1990, Journal of medical virology.

[4]  M. Borzy,et al.  Prolonged defects of interleukin-2 production, responsiveness, and receptor expression in patients with acute lymphoblastic leukemia. , 1989, Blood.

[5]  O. Eden,et al.  Mortality and morbidity caused by measles in children with malignant disease attending four major treatment centres: a retrospective review. , 1987, British medical journal.

[6]  A. Craft,et al.  Measles in children who have malignant disease. , 1987, British medical journal.

[7]  L. Frenkel,et al.  Ontogeny of phytohemagglutinin-induced gamma interferon by leukocytes of healthy infants and children: evidence for decreased production in infants younger than 2 months of age. , 1987, The Journal of pediatrics.

[8]  A. Craft,et al.  Virus infections in childhood malignant disease. , 1987, Pediatric hematology and oncology.

[9]  A. Craft,et al.  Interferon responses of peripheral blood mononuclear cells from normal and leukaemic children , 1986, British Journal of Haematology.

[10]  M. Levin,et al.  Lysis of varicella zoster virus infected cells by lymphocytes from normal humans and immunosuppressed pediatric leukaemic patients. , 1985, Clinical and experimental immunology.

[11]  A. Craft,et al.  Natural killer cell activity in childhood acute lymphoblastic leukaemia in remission , 1985, British journal of haematology.

[12]  D. Frank.  Culture of Animal Cells: A Manual of Basic Technique , 1984, The Yale Journal of Biology and Medicine.

[13]  D. Wong,et al.  Viral infections in immunocompromised patients. , 1983, The Medical clinics of North America.

[14]  H. Meiselman,et al.  Geometry of Neonatal and Adult Red Blood Cells , 1983, Pediatric Research.

[15]  P. Brunell,et al.  ADMINISTRATION OF LIVE VARICELLA VACCINE TO CHILDREN WITH LEUKAEMIA , 1982, The Lancet.

[16]  J. Ninane,et al.  Serious infections during continuing treatment of acute lymphoblastic leukaemia. , 1981, Archives of disease in childhood.

[17]  A. Craft,et al.  Immunoglobulin concentrations in children receiving treatment for acute lymphoblastic leukaemia. , 1981, Journal of clinical pathology.

[18]  G. Toms,et al.  Cellular and antibody response to respiratory syncytial (rs) virus in human colostrum, maternal blood, and cord blood , 1981, Journal of medical virology.

[19]  A. Freeman,et al.  Interferon production and lymphocyte transformation in lymphocytes of leukemic patients. , 1981, Journal of interferon research.

[20]  A. Craft,et al.  Complement fixing antibody responses to virus infection in children with acute lymphoblastic leukaemia. , 1980, Journal of clinical pathology.

[21]  Y. Ravindranath,et al.  Infections in leukemic children: a prospective analysis. , 1980, The Journal of pediatrics.

[22]  K. Mcintosh,et al.  Cellular response to respiratory viruses with particular reference to children with disorders of cell-mediated immunity. , 1980, The Journal of pediatrics.

[23]  A. Leiper,et al.  Infection during remission induction in childhood leukaemia , 1980, Archives of disease in childhood.

[24]  A. Craft,et al.  Virus infections in children with acute lymphoblastic leukaemia. , 1979, Archives of disease in childhood.

[25]  D. Ilstrup,et al.  Response to influenza virus vaccine in children receiving chemotherapy for malignancy. , 1978, The Journal of pediatrics.

[26]  Y. Chiba,et al.  Development of in vitro correlates of cell-mediated immunity to respiratory syncytial virus infection in humans. , 1978, The Journal of infectious diseases.

[27]  C. Hall,et al.  Influenza immunization in immunosuppressed children. , 1978, The Journal of pediatrics.

[28]  H. Kamiya,et al.  Application of a live varicella vaccine in children with acute leukemia or other malignant diseases. , 1977, Pediatrics.

[29]  A. Craft,et al.  Role of infection in the death of children with acute lymphoblastic leukaemia. , 1977, Archives of disease in childhood.

[30]  J. Todd,et al.  Serial studies of numbers of circulating T and B lymphocytes in children with acute lymphoblastic leukaemia. , 1977, Archives of disease in childhood.

[31]  H. Plüss,et al.  Studies on the immune status of children with acute lymphocytic leukemia (ALL). , 1977, Haematology and blood transfusion.

[32]  H. Plüss,et al.  Studies on the immune status of children with acute lymphocytic leukaemia. I. Early phase before and after first remission. , 1976, Clinical and experimental immunology.

[33]  J. Pauly,et al.  Whole blood microculture assay of human lymphocyte function. , 1976, The Journal of laboratory and clinical medicine.

[34]  W. Zuelzer,et al.  IMMUNOGLOBULINS IN ACUTE LEUKEMIA IN CHILDREN , 1974, Pediatric Research.

[35]  L. Borella,et al.  Expression of cell surface markers on T and B lymphocytes after long-term chemotherapy of acute leukemia. , 1973, Cellular immunology.

[36]  D. Char,et al.  Cutaneous delayed hypersensitivity responses to tumor‐associated and other antigens in acute leukemia , 1973 .

[37]  G. D. de Vaan,et al.  Phytohaemagglutinin stimulation of peripheral lymphocytes in children with acute lymphoblastic leukaemia during remission. , 2009, Scandinavian journal of haematology.

[38]  E. Hersh,et al.  Chemotherapy, immunocompetence, immunosuppression and prognosis in acute leukemia. , 1971, The New England journal of medicine.

[39]  R. Webster,et al.  The immunosuppressive effects of long-term combination chemotherapy in children with acute leukemia in remission. , 1971, Cancer research.

[40]  R. Sutherland,et al.  Phytohemagglutinin (PHA)‐induced transformation of lymphocytes from patients with cancer , 1971, Cancer.

[41]  J. Dausset,et al.  Depression of immunologic reactivity of patients with acute leukemia , 1971, Cancer.

[42]  Sung C. Choi,et al.  Immunoglobulin patterns in childhood leukemia , 1970 .

[43]  N. Finter.  Dye Uptake Methods for Assessing Viral Cytopathogenicity and their Application to Interferon Assays , 1969 .

[44]  S. Gross,et al.  The G-immunoglobulins in acute leukemia in children. Hematologic and immunologic relationships. , 1969, Blood.

[45]  A. Böyum.  Isolation and removal of lymphocytes from bone marrow of rats and guinea-pigs. , 1968, Scandinavian journal of clinical and laboratory investigation. Supplementum.