The multiplicity of mutations in human cancers.

[1]  N. Rahman,et al.  Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B , 2004, Nature Genetics.

[2]  R. Weinberg,et al.  Species- and cell type-specific requirements for cellular transformation. , 2004, Cancer cell.

[3]  Juno Choe,et al.  Protein tolerance to random amino acid change. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[4]  T. Kunkel.  DNA Replication Fidelity* , 2004, Journal of Biological Chemistry.

[5]  T. Hubbard,et al.  A census of human cancer genes , 2004, Nature Reviews Cancer.

[6]  D. Wodarz,et al.  Evolutionary dynamics of mutator phenotypes in cancer: implications for chemotherapy. , 2003, Cancer research.

[7]  Martin A. Nowak,et al.  The significance of unstable chromosomes in colorectal cancer , 2003, Nature Reviews Cancer.

[8]  O. Sieber,et al.  Genomic instability — the engine of tumorigenesis? , 2003, Nature Reviews Cancer.

[9]  K. Loeb,et al.  Multiple mutations and cancer , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[10]  Jean Marx,et al.  Debate Surges Over the Origins of Genomic Defects in Cancer , 2002, Science.

[11]  M. Neuberger,et al.  AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification , 2002, Nature.

[12]  Monique Albert,et al.  Parallel analysis of sporadic primary ovarian carcinomas by spectral karyotyping, comparative genomic hybridization, and expression microarrays. , 2002, Cancer research.

[13]  M. Radman,et al.  Specialized DNA Polymerases, Cellular Survival, and the Genesis of Mutations , 2002, Science.

[14]  W. Bodmer,et al.  How many mutations in a cancer? , 2002, The American journal of pathology.

[15]  Giovanni Parmigiani,et al.  Prevalence of somatic alterations in the colorectal cancer cell genome , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Alberto Martin,et al.  Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas , 2002, Nature.

[17]  R. Fishel,et al.  The selection for mismatch repair defects in hereditary nonpolyposis colorectal cancer: revising the mutator hypothesis. , 2001, Cancer research.

[18]  Z. Livneh.  DNA Damage Control by Novel DNA Polymerases: Translesion Replication and Mutagenesis* , 2001, The Journal of Biological Chemistry.

[19]  A. Jackson,et al.  The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. , 2001, Mutation research.

[20]  Robert E. Johnson,et al.  Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites. , 2001, Genes & development.

[21]  S. Markowitz,et al.  DNA repair defects inactivate tumor suppressor genes and induce hereditary and sporadic colon cancers. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[22]  M. Goodman,et al.  The expanding polymerase universe , 2000, Nature Reviews Molecular Cell Biology.

[23]  F. Hanaoka,et al.  Mechanisms of accurate translesion synthesis by human DNA polymerase η , 2000, The EMBO journal.

[24]  P H Patel,et al.  DNA polymerase active site is highly mutable: evolutionary consequences. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[25]  Chikahide Masutani,et al.  Low fidelity DNA synthesis by human DNA polymerase-η , 2000, Nature.

[26]  J. Jen,et al.  Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. , 2000, Science.

[27]  N. Petrelli,et al.  The onset and extent of genomic instability in sporadic colorectal tumor progression. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[28]  M. Bronner,et al.  Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis. , 1999, Cancer research.

[29]  T. Honjo,et al.  Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells* , 1999, The Journal of Biological Chemistry.

[30]  Carissa A. Sanchez,et al.  Evolution of neoplastic cell lineages in Barrett oesophagus , 1999, Nature Genetics.

[31]  M. Speicher,et al.  Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[32]  G. Marsischky,et al.  Eukaryotic DNA mismatch repair. , 1999, Current opinion in genetics & development.

[33]  K. Kinzler,et al.  Genetic instabilities in human cancers , 1998, Nature.

[34]  P. Duesberg,et al.  Genetic instability of cancer cells is proportional to their degree of aneuploidy. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[35]  S. Knuutila,et al.  DNA copy number changes in development and progression in leiomyosarcomas of soft tissues. , 1998, The American journal of pathology.

[36]  A. Jackson,et al.  On the origin of multiple mutations in human cancers. , 1998, Seminars in cancer biology.

[37]  A. Jackson,et al.  The mutation rate and cancer. , 1998, Genetics.

[38]  J. Miller,et al.  Proliferation of mutators in A cell population , 1997, Journal of bacteriology.

[39]  M. Perucho.  Cancer of the microsatellite mutator phenotype. , 1996, Biological chemistry.

[40]  L. Aaltonen,et al.  Somatic microsatellite mutations as molecular tumor clocks , 1996, Nature Medicine.

[41]  F. Mitelman,et al.  Catalog of Chromosome Aberrations in Cancer , 1996, British Journal of Cancer.

[42]  D. Pinkel,et al.  Genetic analysis of benign, low-grade, and high-grade ovarian tumors. , 1995, Cancer research.

[43]  J. Taylor,et al.  Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[44]  P. Modrich.  Mismatch repair, genetic stability and tumour avoidance. , 1995, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[45]  Ware Jl.  Prostate cancer progression. Implications of histopathology. , 1994 .

[46]  J Piper,et al.  Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[47]  S N Thibodeau,et al.  Microsatellite instability in cancer of the proximal colon. , 1993, Science.

[48]  E. E. Gresch.  Genetic Alterations During Colorectal-Tumor Development , 1989 .

[49]  Y. Nakamura,et al.  Genetic alterations during colorectal-tumor development. , 1988, The New England journal of medicine.

[50]  A. Knudson.  Hereditary cancer, oncogenes, and antioncogenes. , 1985, Cancer research.

[51]  D. Comings.  Metabolic basis of inherited disease , 1983 .

[52]  T. Kunkel,et al.  Fidelity of mammalian DNA polymerases. , 1981, Science.

[53]  P. Nowell.  The clonal evolution of tumor cell populations. , 1976, Science.

[54]  L. Loeb,et al.  Errors in DNA replication as a basis of malignant changes. , 1974, Cancer research.

[55]  A. Knudson.  Mutation and cancer: statistical study of retinoblastoma. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[56]  Ian Tomlinson,et al.  Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog , 1999, Nature medicine.

[57]  村松 正道.  Specific expression of activation-induced cytidine deaminase (AID) , a novel member of the RNA editing deaminase family in germinal center B cells , 1999 .

[58]  A. Rowan,et al.  Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumours , 1998, Human mutation.

[59]  B. Singer.  DNA damage: chemistry, repair, and mutagenic potential. , 1996, Regulatory toxicology and pharmacology : RTP.

[60]  J. Miller.  The relevance of bacterial mutators to understanding human cancer. , 1996, Cancer surveys.

[61]  P. Nowell.  Foundations in cancer research. Chromosomes and cancer: the evolution of an idea. , 1993, Advances in cancer research.

[62]  Charles R.scriver.  The Metabolic basis of inherited disease , 1989 .