The Human Brain in a Dish: The Promise of iPSC-Derived Neurons

Induced pluripotent stem cell-derived neurons from patients promise to fill an important niche between studies in humans and model organisms in deciphering mechanisms and identifying therapeutic avenues for neurologic and psychiatric diseases. Recent work begins to tap this potential and also highlights challenges that must be overcome to be fully realized.

[1]  Pasko Rakic,et al.  Renewed focus on the developing human neocortex , 2010, Journal of anatomy.

[2]  Leonard I Zon,et al.  Cell stem cell. , 2007, Cell stem cell.

[3]  D. Geschwind.  Autism: Many Genes, Common Pathways? , 2008, Cell.

[4]  M. Dragunow.  The adult human brain in preclinical drug development , 2008, Nature Reviews Drug Discovery.

[5]  Fred H. Gage,et al.  A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells , 2010, Cell.

[6]  Fred H. Gage,et al.  Modelling schizophrenia using human induced pluripotent stem cells , 2011, Nature.

[7]  Thomas Vierbuchen,et al.  Direct conversion of fibroblasts to functional neurons by defined factors , 2010, Nature.

[8]  Hynek Wichterle,et al.  A functionally characterized test set of human induced pluripotent stem cells , 2011, Nature Biotechnology.

[9]  A. Viale,et al.  Modeling Pathogenesis and Treatment of Familial Dysautonomia using Patient Specific iPSCs , 2009, Nature.

[10]  Daniel H. Geschwind,et al.  Neuroscience in the era of functional genomics and systems biology , 2009, Nature.

[11]  Riitta Lahesmaa,et al.  Copy number variation and selection during reprogramming to pluripotency , 2011, Nature.

[12]  Jonathan A. Bernstein,et al.  Using iPS cells to investigate cardiac phenotypes in patients with Timothy Syndrome , 2011, Nature.

[13]  D. Rujescu,et al.  Penetrance for copy number variants associated with schizophrenia. , 2010, Human molecular genetics.

[14]  E. Kirkness,et al.  Somatic coding mutations in human induced pluripotent stem cells , 2011, Nature.

[15]  R. Rosenfeld.  Nature , 2009, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[16]  G. Daley,et al.  Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. , 2010, Cell stem cell.

[17]  George Q. Daley,et al.  Disease-Specific Induced Pluripotent Stem Cells , 2008, Cell.

[18]  Soyoung Q. Park,et al.  The von economo neurons in apes and humans , 2011, American journal of human biology : the official journal of the Human Biology Council.

[19]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[20]  R. Weksberg,et al.  Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation , 2011, Human molecular genetics.

[21]  Michael J. Ziller,et al.  Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines , 2011, Cell.

[22]  Blake Byers,et al.  LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. , 2011, Cell stem cell.