Selective downregulation of HLA‐C and HLA‐E in childhood acute lymphoblastic leukaemia

We have recently shown that susceptibility to childhood B-cell acute lymphoblastic leukaemia (B-ALL) is influenced by the presence of HLA-C encoded ligands C1 and C2 for killer cell immunoglobulin-like receptors (KIR), (Babor et al, 2014). B-ALL patients exhibited an increased frequency of the C2 ligand and, moreover, C2 was associated with increased risk of late relapse. The study suggested that the expression of HLA class I-encoded KIR ligands on tumour

[1]  A. Borkhardt,et al.  KIR ligand C2 is associated with increased susceptibility to childhood ALL and confers an elevated risk for late relapse. , 2014, Blood.

[2]  F. Hentges,et al.  NK Cell Killer Ig-like Receptor Repertoire Acquisition and Maturation Are Strongly Modulated by HLA Class I Molecules , 2014, The Journal of Immunology.

[3]  A. McMichael,et al.  Reappraisal of the Relationship between the HIV-1-Protective Single-Nucleotide Polymorphism 35 Kilobases Upstream of the HLA-C Gene and Surface HLA-C Expression , 2011, Journal of Virology.

[4]  D. Ge,et al.  HLA-C cell surface expression and control of HIV / AIDS correlate with a variant upstream of HLA-C , 2009 .

[5]  F. Claas,et al.  Role of the inhibitory KIR ligand HLA-Bw4 and HLA-C expression levels in the recognition of leukemic cells by Natural Killer cells , 2009, Cancer Immunology, Immunotherapy.

[6]  D. Majumder,et al.  Lack of HLA-E surface expression is due to deficiency of HLA-E transcripts in the malignant hematopoietic cells of leukemic patients. , 2006, Leukemia research.

[7]  E. Lanino,et al.  Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112). , 2005, Blood.

[8]  A. McMichael,et al.  TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide , 1998, Current Biology.

[9]  D. Geraghty,et al.  Polymorphism at the HLA-E locus predates most HLA-A and -B polymorphism. , 1992, Human immunology.