Quantitative Ultrasound and Trabecular Architecture in the Human Calcaneus *

Relationships between quantitative ultrasound (QUS), density (bone volume density [BV/TV]), and trabecular architecture were investigated in 69 calcaneal cancellous bone cubes. Ultrasound signal velocity, phase velocity, attenuation, and broadband ultrasonic attenuation (BUA) measurements were made along the mediolateral axis. Density and architectural parameters were measured using microcomputed tomography (μCT). Density yielded the best correlations with QUS (r2 = 73–77%). Of the individual architectural parameters, correlations with QUS were highest for the Structure Model Index (SMI), a parameter quantifying the relative proportion of rods and plates (r2 = 57–63%). After adjustment for density, significant associations with QUS remained for SMI, trabecular spacing (Tb.Sp), and trabecular number (Tb.N), although the variance in QUS attributable uniquely to individual architectural parameters was at best 4%. In multivariate regression models, combinations of density and architectural parameters explained 76–82% of the variance in QUS, representing an r2 increase of, at most, 8% compared with using density alone. However, multivariate models using combinations of architectural parameters alone (i.e., density excluded) also had a good predictive ability for QUS (r2 = 73–81%). Thus, although these data show modest but significant density‐independent relationships between QUS and trabecular architecture in the human calcaneus for the first time, the causal relationships behind the variation in acoustic properties remain obscure. Given the relative weakness and complexity of the emerging associations between QUS and architecture, it is prudent to regard QUS measurements in calcaneal bone primarily as an indicator of bone density.

[1]  M. Kleerekoper,et al.  Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss. , 1983, The Journal of clinical investigation.

[2]  S. B. Palmer,et al.  Prediction of hip fracture in elderly women: a prospective study. , 1990, BMJ.

[3]  J. A. Evans,et al.  The effect of bone structure on ultrasonic attenuation and velocity. , 1992, Ultrasonics.

[4]  C. Langton,et al.  P29. Dependence of ultrasonic and mechanical properties of vertebral bone on orientation , 1994 .

[5]  J Dequeker,et al.  Assessment of quality of bone in osteoporosis--BIOMED I: fundamental study of relevant bone. , 1994, Clinical rheumatology.

[6]  P. Nicholson,et al.  The dependence of ultrasonic properties on orientation in human vertebral bone. , 1994, Physics in medicine and biology.

[7]  C M Langton,et al.  The role of ultrasound in the assessment of osteoporosis. , 1994, Clinical rheumatology.

[8]  A M Schott,et al.  Do ultrasound measurements on the os calcis reflect more the bone microarchitecture than the bone mass?: a two-dimensional histomorphometric study. , 1995, Bone.

[9]  G. Breart,et al.  Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study , 1996, The Lancet.

[10]  C F Njeh,et al.  The non-linear relationship between BUA and porosity in cancellous bone. , 1996, Physics in medicine and biology.

[11]  J. Currey,et al.  Prediction of mechanical properties of the human calcaneus by broadband ultrasonic attenuation. , 1996, Bone.

[12]  G Lowet,et al.  Assessment of the strength of the proximal femur in vitro: relationship with ultrasonic measurements of the calcaneus. , 1997, Bone.

[13]  P. Rüegsegger,et al.  A new method for the model‐independent assessment of thickness in three‐dimensional images , 1997 .

[14]  P Rüegsegger,et al.  Micro-tomographic imaging for the nondestructive evaluation of trabecular bone architecture. , 1997, Studies in health technology and informatics.

[15]  TOR Hildebrand,et al.  Quantification of Bone Microarchitecture with the Structure Model Index. , 1997, Computer methods in biomechanics and biomedical engineering.

[16]  G Berger,et al.  In vitro assessment of the relationship between acoustic properties and bone mass density of the calcaneus by comparison of ultrasound parametric imaging and quantitative computed tomography. , 1997, Bone.

[17]  J. Cauley,et al.  Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women. A prospective study. Study of Osteoporotic Fractures Research Group. , 1997, Archives of Internal Medicine.

[18]  Fractal dimension predicts broadband ultrasound attenuation in stereolithography models of cancellous bone. , 1998, Physics in medicine and biology.

[19]  H. K. Genant,et al.  Ultrasound Characterization of Bone Demineralization , 1998, Calcified Tissue International.

[20]  P Rüegsegger,et al.  Do quantitative ultrasound measurements reflect structure independently of density in human vertebral cancellous bone? , 1998, Bone.

[21]  K. Wear.  Frequency dependence of ultrasonic backscatter from human trabecular bone: theory and experiment. , 1999, The Journal of the Acoustical Society of America.

[22]  P. Rüegsegger,et al.  Direct Three‐Dimensional Morphometric Analysis of Human Cancellous Bone: Microstructural Data from Spine, Femur, Iliac Crest, and Calcaneus , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[23]  M. Bouxsein,et al.  Scattering of ultrasound in cancellous bone: predictions from a theoretical model. , 2000, Journal of biomechanics.

[24]  P. Nicholson,et al.  Quantitative Ultrasound Does Not Reflect Mechanically Induced Damage in Human Cancellous Bone , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.