Association of Vitamin E Levels with Metabolic Syndrome, and MRI-Derived Body Fat Volumes and Liver Fat Content

We aimed to relate circulating α- and γ-tocopherol levels to a broad spectrum of adiposity-related traits in a cross-sectional Northern German study. Anthropometric measures were obtained, and adipose tissue volumes and liver fat were quantified by magnetic resonance imaging in 641 individuals (mean age 61 years; 40.6% women). Concentrations of α- and γ-tocopherol were measured using high performance liquid chromatography. Multivariable-adjusted linear and logistic regression were used to assess associations of circulating α- and γ-tocopherol/cholesterol ratio levels with visceral (VAT) and subcutaneous adipose tissue (SAT), liver signal intensity (LSI), fatty liver disease (FLD), metabolic syndrome (MetS), and its individual components. The α-tocopherol/cholesterol ratio was positively associated with VAT (β scaled by interquartile range (IQR): 0.036; 95%Confidence Interval (CI): 0.0003; 0.071) and MetS (Odds Ratio (OR): 1.83; 95% CI: 1.21–2.76 for 3rd vs. 1st tertile), and the γ-tocopherol/cholesterol ratio was positively associated with VAT (β scaled by IQR: 0.066; 95% CI: 0.027; 0.104), SAT (β scaled by IQR: 0.048; 95% CI: 0.010; 0.087) and MetS (OR: 1.87; 95% CI: 1.23–2.84 for 3rd vs. 1st tertile). α- and γ-tocopherol levels were positively associated with high triglycerides and low high density lipoprotein cholesterol levels (all Ptrend < 0.05). No association of α- and γ-tocopherol/cholesterol ratio with LSI/FLD was observed. Circulating vitamin E levels displayed strong associations with VAT and MetS. These observations lay the ground for further investigation in longitudinal studies.

[1]  International Association for the Study of Obesity , 2018, The Grants Register 2019.

[2]  G. Marchesini,et al.  AISF position paper on nonalcoholic fatty liver disease (NAFLD): Updates and future directions. , 2017, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[3]  R. Bruno,et al.  Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial. , 2017, The American journal of clinical nutrition.

[4]  M. Post,et al.  α-Tocopherol transfer protein mediates protective hypercapnia in murine ventilator-induced lung injury , 2017, Thorax.

[5]  D. Moczulski,et al.  Lower Plasma Levels of Antioxidant Vitamins in Patients with Metabolic Syndrome: A Case Control Study. , 2016, Advances in clinical and experimental medicine : official organ Wroclaw Medical University.

[6]  Stefan Lorkowski,et al.  Complexity of vitamin E metabolism. , 2016, World journal of biological chemistry.

[7]  F. Violi,et al.  Oxidative stress: New insights on the association of non-alcoholic fatty liver disease and atherosclerosis. , 2015, World journal of hepatology.

[8]  U. Nöthlings,et al.  MRI-determined total volumes of visceral and subcutaneous abdominal and trunk adipose tissue are differentially and sex-dependently associated with patterns of estimated usual nutrient intake in a northern German population. , 2015, The American journal of clinical nutrition.

[9]  M. Failla,et al.  α‐Tocopherol Bioavailability is Lower in Adults with Metabolic Syndrome Regardless of Dairy Fat Co‐Ingestion , 2015, The American journal of clinical nutrition.

[10]  Luigi Fabrizio Rodella,et al.  Metabolic syndrome, aging and involvement of oxidative stress. , 2015, Aging and disease.

[11]  S. Manti,et al.  Oxidative Stress in Obesity: A Critical Component in Human Diseases , 2014, International journal of molecular sciences.

[12]  U. Nöthlings,et al.  Comparison of two exploratory dietary patterns in association with the metabolic syndrome in a Northern German population , 2014, British Journal of Nutrition.

[13]  Q. Jiang.  Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy. , 2014, Free radical biology & medicine.

[14]  U. Nöthlings,et al.  Dietary patterns associated with magnetic resonance imaging-determined liver fat content in a general population study. , 2014, The American journal of clinical nutrition.

[15]  V. Wiwanitkit.  Oxidative Stress and Metabolic Syndrome , 2014, Korean journal of family medicine.

[16]  M. Traber.  Mechanisms for the prevention of vitamin E excess , 2013, Journal of Lipid Research.

[17]  P. Borel,et al.  Bioavailability of vitamin E in humans: an update. , 2013, Nutrition reviews.

[18]  Yanrong Li,et al.  Serum and dietary antioxidant status is associated with lower prevalence of the metabolic syndrome in a study in Shanghai, China. , 2013, Asia Pacific journal of clinical nutrition.

[19]  E. Klein,et al.  Expression of the α-tocopherol transfer protein gene is regulated by oxidative stress and common single-nucleotide polymorphisms. , 2012, Free radical biology & medicine.

[20]  A. Sanyal,et al.  Vitamin E and nonalcoholic fatty liver disease , 2012, Current opinion in clinical nutrition and metabolic care.

[21]  L. Kolonel,et al.  Predicting Total, Abdominal, Visceral and Hepatic Adiposity with Circulating Biomarkers in Caucasian and Japanese American Women , 2012, PloS one.

[22]  Henry Völzke,et al.  Multicausality in fatty liver disease: is there a rationale to distinguish between alcoholic and non-alcoholic origin? , 2012, World journal of gastroenterology.

[23]  K. Long,et al.  Zinc, vitamin A, and vitamin C status are associated with leptin concentrations and obesity in Mexican women: results from a cross-sectional study , 2012, Nutrition & Metabolism.

[24]  U. Nöthlings,et al.  [PopGen. A population-based biobank with prospective follow-up of a control group]. , 2012, Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz.

[25]  U. Jeschke,et al.  Oxidative stress stimulates α-tocopherol transfer protein in human trophoblast tumor cells BeWo , 2012, Journal of perinatal medicine.

[26]  David R Bassett,et al.  2011 Compendium of Physical Activities: a second update of codes and MET values. , 2011, Medicine and science in sports and exercise.

[27]  A. Zonderman,et al.  Serum antioxidant status is associated with metabolic syndrome among U.S. adults in recent national surveys. , 2011, The Journal of nutrition.

[28]  D. Häussinger,et al.  Plasma levels of vitamin E and carotenoids are decreased in patients with nonalcoholic steatohepatitis (NASH) , 2011, European journal of medical research.

[29]  G. Bray,et al.  The Relationship of Waist Circumference and BMI to Visceral, Subcutaneous, and Total Body Fat: Sex and Race Differences , 2011, Obesity.

[30]  Jan Kassubek,et al.  Quantification of human body fat tissue percentage by MRI , 2011, NMR in biomedicine.

[31]  B. Neuschwander‐Tetri,et al.  Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. , 2010, The New England journal of medicine.

[32]  G. Maskarinec,et al.  Associations between obesity and serum lipid-soluble micronutrients among premenopausal women. , 2010, Nutrition research.

[33]  S. Grundy,et al.  Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International As , 2009, Circulation.

[34]  G. Rimbach,et al.  Dietary green tea polyphenols do not affect vitamin E status, antioxidant capacity and meat quality of growing pigs. , 2008, Journal of animal physiology and animal nutrition.

[35]  Robert L Tanguay,et al.  Fullerene C60 exposure elicits an oxidative stress response in embryonic zebrafish. , 2008, Toxicology and applied pharmacology.

[36]  P. Ravasco,et al.  Blood oxidative stress markers in non-alcoholic steatohepatitis and how it correlates with diet , 2008, Scandinavian journal of gastroenterology.

[37]  U. Nöthlings,et al.  Fitting portion sizes in a self-administered food frequency questionnaire. , 2007, The Journal of nutrition.

[38]  M. Fonseca-Alaniz,et al.  Adipose tissue as an endocrine organ: from theory to practice. , 2007, Jornal de pediatria.

[39]  Julie Takada,et al.  O tecido adiposo como órgão endócrino: da teoria à prática: [revisão] , 2007 .

[40]  M. Traber.  Vitamin E regulatory mechanisms. , 2007, Annual review of nutrition.

[41]  Michael Krawczak,et al.  PopGen: Population-Based Recruitment of Patients and Controls for the Analysis of Complex Genotype-Phenotype Relationships , 2006, Public Health Genomics.

[42]  P. Galan,et al.  Serum concentrations of β-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population , 2005, European Journal of Clinical Nutrition.

[43]  S. Grundy,et al.  Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. , 2005, American journal of physiology. Endocrinology and metabolism.

[44]  N. Ilhan,et al.  Levels of serum vitamin A, alpha‐tocopherol and malondialdehyde in patients with non‐alcoholic steatohepatitis: relationship with histopathologic severity , 2004, International journal of clinical practice.

[45]  A. Mokdad,et al.  The metabolic syndrome and antioxidant concentrations: findings from the Third National Health and Nutrition Examination Survey. , 2003, Diabetes.

[46]  F. Clavel-Chapelon,et al.  Physical activity of subjects aged 50–64 years involved in the European Prospective Investigation into Cancer and Nutrition (EPIC) , 2002, Public Health Nutrition.

[47]  B Gullberg,et al.  Serum concentrations of beta-carotene and alpha-tocopherol are associated with diet, smoking, and general and central adiposity. , 2001, The American journal of clinical nutrition.

[48]  E. Hermann-Kunz,et al.  The German Food Code and Nutrient Data Base (BLS II.2) , 1999, European Journal of Epidemiology.

[49]  Hiroyuki Arai,et al.  Affinity for α‐tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs , 1997, FEBS letters.

[50]  M. Traber,et al.  Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans. , 1993, Journal of lipid research.

[51]  R. D. Situnayake,et al.  The Use of Different Lipids to Express Serum Tocopherol: Lipid Ratios for the Measurement of Vitamin E Status , 1986, Annals of clinical biochemistry.

[52]  J. Ard,et al.  Longitudinal association of measures of adiposity with serum antioxidant concentrations in postmenopausal women , 2016, European Journal of Clinical Nutrition.

[53]  G. Marchesini,et al.  Cardiovascular risk, lipidemic phenotype and steatosis. A comparative analysis of cirrhotic and non-cirrhotic liver disease due to varying etiology. , 2014, Atherosclerosis.

[54]  Manor,et al.  Expression of the Alpha Tocopherol Transfer Protein gene is regulated by Oxidative Stress and Common Single Nucleotide Polymorphisms , 2013 .