Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation
暂无分享,去创建一个
Bin Fang | Weiwei Zhu | Charlene Rivera | Y. Ann Chen | John Koomen | Domenico Coppola | Ernst Schönbrunn | D. Coppola | J. Cheng | R. Engelman | K. Mahajan | E. Schönbrunn | S. Sebti | N. Mahajan | Weiwei Zhu | J. Koomen | H. Earp | B. Fang | S. Challa | H. Shelton Earp | Alexis S. Lopez | Y. A. Chen | Said M. Sebti | Jin Q. Cheng | Kiran Mahajan | Nupam P. Mahajan | Sridevi Challa | Robert W. Engelman | Rebecca S. Muraoka-Cook | R. Muraoka-Cook | C. Rivera | H. Shelton Earp | Ernst Schö Nbrunn | Chris Jones | H. Shelton Earp
[1] Yiling Lu,et al. Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery , 2005, Nature Reviews Drug Discovery.
[2] D. Tindall,et al. Dynamic FoxO transcription factors , 2007, Journal of Cell Science.
[3] T. Ono,et al. Infrequent Genetic Alterations of the PTEN/MMAC1 Gene in Japanese Patients with Primary Cancers of the Breast, Lung, Pancreas, Kidney, and Ovary , 1997, Japanese journal of cancer research : Gann.
[4] Activated AKT/PKB signaling in C. elegans uncouples temporally distinct outputs of DAF-2/insulin-like signaling , 2006, BMC Developmental Biology.
[5] J. Testa,et al. Activation of AKT kinases in cancer: implications for therapeutic targeting. , 2005, Advances in cancer research.
[6] J. Mohler,et al. Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation , 2007, Proceedings of the National Academy of Sciences.
[7] L. Cantley,et al. PI3K pathway alterations in cancer: variations on a theme , 2008, Oncogene.
[8] N. Mahajan,et al. An SH2 Domain-dependent, Phosphotyrosine-independent Interaction between Vav1 and the Mer Receptor Tyrosine Kinase , 2003, Journal of Biological Chemistry.
[9] Huan Yang,et al. The Akt/PKB pathway: molecular target for cancer drug discovery , 2005, Oncogene.
[10] Lewis C. Cantley,et al. AKT/PKB Signaling: Navigating Downstream , 2007, Cell.
[11] Jerónimo Bravo,et al. Binding of the PX domain of p47phox to phosphatidylinositol 3,4‐bisphosphate and phosphatidic acid is masked by an intramolecular interaction , 2002, The EMBO journal.
[12] Spyro Mousses,et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer , 2007, Nature.
[13] F. McCormick,et al. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. , 1998, Science.
[14] W. Miller,et al. Biochemical Properties of the Cdc42-associated Tyrosine Kinase ACK1 , 2003, Journal of Biological Chemistry.
[15] D. Coppola,et al. Effect of Ack1 tyrosine kinase inhibitor on ligand‐independent androgen receptor activity , 2010, The Prostate.
[16] L. Beckett,et al. Incidence, mechanism and prognostic value of activated AKT in pancreas cancer , 2003, British Journal of Cancer.
[17] Hoyun Lee,et al. The Akt isoforms are present at distinct subcellular locations. , 2010, American journal of physiology. Cell physiology.
[18] J. Carpten,et al. PI3K/AKT pathway activation in acute myeloid leukaemias is not associated with AKT1 pleckstrin homology domain mutation , 2008, British journal of haematology.
[19] D. Guertin,et al. Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex , 2005, Science.
[20] R. Pearson,et al. Direct Identification of Tyrosine 474 as a Regulatory Phosphorylation Site for the Akt Protein Kinase* 210 , 2002, The Journal of Biological Chemistry.
[21] Yiling Lu,et al. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. , 2009, Cancer cell.
[22] B. Burgering,et al. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction , 1995, Nature.
[23] S. Powers,et al. Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[24] F. McCormick,et al. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. , 1997, Science.
[25] Y. Qiu,et al. Regulation of Akt/PKB Activation by Tyrosine Phosphorylation* , 2001, The Journal of Biological Chemistry.
[26] Hailing Cheng,et al. The p110α isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation , 2006, Proceedings of the National Academy of Sciences.
[27] Carmen Blanco-Aparicio,et al. PTEN, more than the AKT pathway. , 2007, Carcinogenesis.
[28] M. Tada,et al. Differential Mechanisms of Constitutive Akt/PKB Activation and Its Influence on Gene Expression in Pancreatic Cancer Cells , 2002, Japanese journal of cancer research : Gann.
[29] L. Lim,et al. A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42 , 1993, Nature.
[30] F. Liu,et al. PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle. , 2005, American journal of physiology. Endocrinology and metabolism.
[31] J. Ptak,et al. High Frequency of Mutations of the PIK3CA Gene in Human Cancers , 2004, Science.
[32] C. Sawyers,et al. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.
[33] Zhi Hu,et al. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. , 2008, Cancer research.
[34] T. Kataoka,et al. Stimulation of Ras Guanine Nucleotide Exchange Activity of Ras-GRF1/CDC25Mm upon Tyrosine Phosphorylation by the Cdc42-regulated Kinase ACK1* , 2000, Journal of Biological Chemistry.
[35] E. Greer,et al. FOXO transcription factors at the interface between longevity and tumor suppression , 2005, Oncogene.
[36] J. Schlessinger,et al. Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[37] S. Pinder,et al. The role of PTEN and its signalling pathways, including AKT, in breast cancer; an assessment of relationships with other prognostic factors and with outcome , 2004, The Journal of pathology.
[38] Terry L. Smith,et al. Activation of the Akt/Mammalian Target of Rapamycin/4E-BP1 Pathway by ErbB2 Overexpression Predicts Tumor Progression in Breast Cancers , 2004, Clinical Cancer Research.
[39] D. Bar-Sagi,et al. Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos , 2007, Nature Cell Biology.
[40] P. Cohen,et al. Mechanism of activation of protein kinase B by insulin and IGF‐1. , 1996, The EMBO journal.
[41] James L Mohler,et al. Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox. , 2005, Cancer research.
[42] Wannian Yang,et al. Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation. , 2007, Molecular biology of the cell.
[43] Andrius Kazlauskas,et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase , 1995, Cell.
[44] J E Paciga,et al. AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. , 2001, The American journal of pathology.
[45] S. Bose,et al. The Akt pathway in human breast cancer: a tissue-array-based analysis , 2006, Modern Pathology.