Common fragile sites, extremely large genes, neural development and cancer.

[1]  J. Pouysségur,et al.  The gene encoding human retinoic acid-receptor-related orphan receptor alpha is a target for hypoxia-inducible factor 1. , 2004, The Biochemical journal.

[2]  R. Weigel,et al.  Physical and Functional Interactions between the Wwox Tumor Suppressor Protein and the AP-2γ Transcription Factor , 2004, Cancer Research.

[3]  F. Apiou,et al.  Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer , 2004, Oncogene.

[4]  K. Niakan,et al.  IL1RAPL1 is associated with mental retardation in patients with complex glycerol kinase deficiency who have deletions extending telomeric of DAX1 , 2004, Human mutation.

[5]  L. Miraglia,et al.  A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock , 2004, Neuron.

[6]  J. Heath,et al.  Down-regulation of WW Domain-containing Oxidoreductase Induces Tau Phosphorylation in Vitro , 2004, Journal of Biological Chemistry.

[7]  Yonghe Li,et al.  The Low Density Lipoprotein Receptor-related Protein 1B Retains β-Amyloid Precursor Protein at the Cell Surface and Reduces Amyloid-β Peptide Production* , 2004, Journal of Biological Chemistry.

[8]  M. Farrer,et al.  N-myc Regulates Parkin Expression* , 2004, Journal of Biological Chemistry.

[9]  J. Ludes-Meyers,et al.  WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins , 2004, Oncogene.

[10]  Fang Wang,et al.  Parkin gene alterations in hepatocellular carcinoma , 2004, Genes, chromosomes & cancer.

[11]  Y. Pekarsky,et al.  Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[12]  C. Croce,et al.  Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses. , 2004, Current gene therapy.

[13]  D. Smeets,et al.  The most common fragile site in man is 3p14 , 1986, Human Genetics.

[14]  C. Croce,et al.  Common fragile genes. , 2004, European journal of histochemistry : EJH.

[15]  M. Justice,et al.  The neurological mutant quakingviable is Parkin deficient , 2004, Mammalian Genome.

[16]  C. Croce,et al.  Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: Evolutionarily conserved but highly recombinogenic , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[17]  C. Klein,et al.  Alterations in the common fragile site gene Parkin in ovarian and other cancers , 2003, Oncogene.

[18]  David I. Smith,et al.  Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma , 2003, Oncogene.

[19]  J. Heath,et al.  Molecular mechanisms underlying WOX1 activation during apoptotic and stress responses. , 2003, Biochemical pharmacology.

[20]  P. Heutink,et al.  CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder. , 2003, Genomics.

[21]  David I. Smith,et al.  Common fragile sites are preferential targets for HPV16 integrations in cervical tumors , 2003, Oncogene.

[22]  M. Z. Limongi,et al.  Characterization of the human common fragile site FRA2G. , 2003, Genomics.

[23]  David I. Smith,et al.  Evidence that instability within the FRA3B region extends four megabases , 2002, Oncogene.

[24]  David I. Smith,et al.  Cloning and characterization of the common fragile site FRA6F harboring a replicative senescence gene and frequently deleted in human tumors , 2002, Oncogene.

[25]  David I. Smith,et al.  Transcriptional profiling reveals that several common fragile‐site genes are downregulated in ovarian cancer , 2002, Genes, chromosomes & cancer.

[26]  E. Calhoun,et al.  The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1 , 2002, Genes, chromosomes & cancer.

[27]  H. Prydz,et al.  Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors , 2002, Oncogene.

[28]  J. Zucman‐Rossi,et al.  Specific association between alcohol intake, high grade of differentiation and 4q34-q35 deletions in hepatocellular carcinomas identified by high resolution allelotyping , 2002, Oncogene.

[29]  D. Beer,et al.  Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells , 2002, Genes, chromosomes & cancer.

[30]  A. Brenner,et al.  WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. , 2001, Cancer research.

[31]  C. Ross,et al.  Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease , 2001, Nature Medicine.

[32]  L. Roberts,et al.  The characterization of the common fragile site FRA16D and its involvement in multiple myeloma translocations. , 2000, Genomics.

[33]  J. Mariani,et al.  Bax Inactivation in Lurcher Mutants Rescues Cerebellar Granule Cells But Not Purkinje Cells or Inferior Olivary Neurons , 2000, The Journal of Neuroscience.

[34]  R. Richards,et al.  Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells. , 2000, Human molecular genetics.

[35]  S. Korsmeyer,et al.  Neurodegeneration in Lurcher Mice Occurs via Multiple Cell Death Pathways , 2000, The Journal of Neuroscience.

[36]  A. Bednarek,et al.  WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. , 2000, Cancer research.

[37]  R. Richards,et al.  Fragile sites still breaking. , 1998, Trends in genetics : TIG.

[38]  S. Scherer,et al.  Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[39]  A. Wolfson,et al.  Diadenosine oligophosphates (Ap n A), a novel class of signalling molecules? , 1998, FEBS letters.

[40]  S. Minoshima,et al.  Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism , 1998, Nature.

[41]  M. L. Le Beau,et al.  An FHIT tumor suppressor gene? , 1998, Genes, chromosomes & cancer.

[42]  Haojie Huang,et al.  Fish mapping of YAC clones at human chromosomal band 7q31.2: Identification of YACS spanning FRA7G within the common region of LOH in breast and prostate cancer , 1998, Genes, chromosomes & cancer.

[43]  V. Giguère,et al.  Orphan nuclear receptor RORα-deficient mice display the cerebellar defects of staggerer , 1998, Mechanisms of Development.

[44]  K. Huebner,et al.  FHITness and cancer. , 1998, Oncology research.

[45]  T. Glover.  Instability at chromosomal fragile sites. , 1998, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[46]  H. Huang,et al.  Common fragile sites and cancer (review). , 1998, International journal of oncology.

[47]  C. Harris,et al.  FHIT mutations in human primary gastric cancer. , 1997, Cancer research.

[48]  C. Croce,et al.  Structure and expression of the human FHIT gene in normal and tumor cells. , 1997, Cancer research.

[49]  R. Shridhar,et al.  A 350-kb cosmid contig in 3p14.2 that crosses the t(3;8) hereditary renal cell carcinoma translocation breakpoint and 17 aphidicolin-induced FRA3B breakpoints. , 1996, Genomics.

[50]  S. Jacobs,et al.  Hereditary renal-cell carcinoma associated with a chromosomal translocation. , 1979, The New England journal of medicine.