2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors.

To the Editor: I have a question about the article by Massad et al in the April 2013 issue of the journal. On page 840, the authors state, "For women aged 21–24 years with CIN 1 after ASC-H or HSIL cytology, observation for up to 24 months using both colposcopy and cytology at 6-month intervals is recommended, provided the colposcopic examination is adequate and endocervical assessment is negative (BIII).” Yet, on the same page, under the heading "Management of Women With CIN 1 or No Lesion Preceded by ASCH or HSIL," the recommendation is, "When CIN 2+ is not identified histologically, either a diagnostic excisional procedure or observation with co-testing at 12 months and 24 months is recommended, provided in the latter case that the colposcopic examination is adequate and the endocervical sampling is negative." Why is the recommended management for women aged 21–24 years more aggressive than for older women?

[1]  Richard G. Moore,et al.  Evaluation of the Diagnostic Accuracy of the Risk of Ovarian Malignancy Algorithm in Women With a Pelvic Mass , 2011, Obstetrics and gynecology.

[2]  Joy Anderson,et al.  Effect of maternal body mass index on serum magnesium levels given for seizure prophylaxis. , 2013, Obstetrics and gynecology.

[3]  A. Jazaeri,et al.  A nomogram for estimating the probability of ovarian cancer. , 2011, Gynecologic oncology.

[4]  Steven J Skates,et al.  A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass. , 2009, Gynecologic oncology.

[5]  I. Hellstrom,et al.  SMRP and HE4 as biomarkers for ovarian carcinoma when used alone and in combination with CA125 and/or each other. , 2008, Advances in experimental medicine and biology.

[6]  M. Schiffman,et al.  2012 Updated Consensus Guidelines for the Management of Abnormal Cervical Cancer Screening Tests and Cancer Precursors , 2013, Journal of lower genital tract disease.

[7]  S. Thylan Prospective multicenter study on CA 125 in postmenopausal pelvic masses. , 1995, Gynecologic oncology.

[8]  R. Kryscio,et al.  Preoperative differentiation of malignant from benign ovarian tumors: the efficacy of morphology indexing and Doppler flow sonography. , 2003, Gynecologic oncology.

[9]  Zhen Zhang,et al.  Effectiveness of a Multivariate Index Assay in the Preoperative Assessment of Ovarian Tumors , 2011, Obstetrics and gynecology.

[10]  R. Bast,et al.  The CA 125 tumour-associated antigen: a review of the literature. , 1989, Human reproduction.