Quantum coherence in ion channels: resonances, transport and verification

Recently it was demonstrated that long-lived quantum coherence exists during excitation energy transport in photosynthesis. It is a valid question up to which length, time and mass scales quantum coherence may extend, how one may detect this coherence and what, if any, role it plays in the dynamics of the system. Here we suggest that the selectivity filter of ion channels may exhibit quantum coherence, which might be relevant for the process of ion selectivity and conduction. We show that quantum resonances could provide an alternative approach to ultrafast two-dimensional (2D) spectroscopy to probe these quantum coherences. We demonstrate that the emergence of resonances in the conduction of ion channels that are modulated periodically by time-dependent external electric fields can serve as signatures of quantum coherence in such a system. Assessments of experimental feasibility and specific paths towards the experimental realization of such experiments are presented.

[1]  Anne-Marie Welling,et al.  Work in progress. , 2012, Nursing standard (Royal College of Nursing (Great Britain) : 1987).

[2]  Maira Amezcua,et al.  Quantum Optics , 2012 .

[3]  Animesh Datta,et al.  Entanglement and entangling power of the dynamics in light-harvesting complexes , 2009, 0912.0122.

[4]  Animesh Datta,et al.  Noise-assisted energy transfer in quantum networks and light-harvesting complexes , 2009, 0910.4153.

[5]  R. Silbey,et al.  Optimization of exciton trapping in energy transfer processes. , 2009, The journal of physical chemistry. A.

[6]  Emma Springate,et al.  Instantaneous mapping of coherently coupled electronic transitions and energy transfers in a photosynthetic complex using angle-resolved coherent optical wave-mixing. , 2009, Physical review letters.

[7]  Animesh Datta,et al.  Highly efficient energy excitation transfer in light-harvesting complexes: The fundamental role of n , 2009, 0901.4454.

[8]  G. Scholes,et al.  Coherent Intrachain Energy Migration in a Conjugated Polymer at Room Temperature , 2009, Science.

[9]  M. B. Plenio,et al.  Dephasing-assisted transport: quantum networks and biomolecules , 2008, 0807.4902.

[10]  S. Lloyd,et al.  Environment-assisted quantum walks in photosynthetic energy transfer. , 2008, The Journal of chemical physics.

[11]  Neil F. Johnson,et al.  Efficiency of energy transfer in a light-harvesting system under quantum coherence , 2007, 0708.1159.

[12]  R. Hochstrasser,et al.  Two-dimensional spectroscopy at infrared and optical frequencies , 2007, Proceedings of the National Academy of Sciences.

[13]  P. Hamm,et al.  Ultrafast 2D-IR spectroscopy of transient species. , 2007, Chemphyschem : a European journal of chemical physics and physical chemistry.

[14]  A. Baumgaertner,et al.  Cooperative transport in a potassium ion channel. , 2007, The Journal of chemical physics.

[15]  A. Tokmakoff.  Shining Light on the Rapidly Evolving Structure of Water , 2007, Science.

[16]  T. Mančal,et al.  Evidence for wavelike energy transfer through quantum coherence in photosynthetic systems , 2007, Nature.

[17]  Ilya J. Finkelstein,et al.  Probing dynamics of complex molecular systems with ultrafast 2D IR vibrational echo spectroscopy. , 2007, Physical chemistry chemical physics : PCCP.

[18]  M. Cetron,et al.  Biodiesel production : a preliminary study from Jatropha Curcas , 2013 .

[19]  K. Eckert,et al.  Efficient quantum state transfer in spin chains via adiabatic passage , 2007, quant-ph/0702082.

[20]  Energy distribution and ion selectivity of the bacterial potassium channel , 2006, Biofizika.

[21]  D. Triggle,et al.  Voltage-Gated Ion Channels as Drug Targets: TRIGGLE: VOLTAGE-GATED ION CHANNELS AS DRUG TARGETS O-BK , 2006 .

[22]  R. MacKinnon,et al.  Principles of Selective Ion Transport in Channels and Pumps , 2005, Science.

[23]  P. Hānggi,et al.  Driven quantum transport on the nanoscale , 2004, cond-mat/0409251.

[24]  P. Davies,et al.  Does quantum mechanics play a non-trivial role in life? , 2004, Bio Systems.

[25]  B. Roux,et al.  Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands , 2004, Nature.

[26]  K. Schulten,et al.  Computational studies of membrane channels. , 2004, Structure.

[27]  Ashraf Kitmitto,et al.  The Three-dimensional Structure of the Cardiac L-type Voltage-gated Calcium Channel , 2004, Journal of Biological Chemistry.

[28]  Peter C. Jordan,et al.  Modeling permeation energetics in the KcsA potassium channel. , 2003, Biophysical journal.

[29]  N. Demirdöven,et al.  Correlated vibrational dynamics revealed by two-dimensional infrared spectroscopy. , 2002, Physical review letters.

[30]  G. Yellen.  The voltage-gated potassium channels and their relatives , 2002, Nature.

[31]  Youxing Jiang,et al.  Crystal structure and mechanism of a calcium-gated potassium channel , 2002, Nature.

[32]  R. Dutzler,et al.  X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity , 2002, Nature.

[33]  Roderick MacKinnon,et al.  Energetic optimization of ion conduction rate by the K+ selectivity filter , 2001, Nature.

[34]  B. Roux,et al.  Energetics of ion conduction through the K + channel , 2022 .

[35]  A. Tokmakoff,et al.  Signatures of vibrational interactions in coherent two-dimensional infrared spectroscopy , 2001 .

[36]  J. Adelman,et al.  Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin , 2001, Nature.

[37]  N. Grigorieff,et al.  Three-dimensional structure of a voltage-gated potassium channel at 2.5 nm resolution. , 2001, Structure.

[38]  Max Tegmark,et al.  The importance of quantum decoherence in brain processes , 1999, ArXiv.

[39]  R. Hochstrasser,et al.  STRUCTURE OF THE AMIDE I BAND OF PEPTIDES MEASURED BY FEMTOSECOND NONLINEAR-INFRARED SPECTROSCOPY , 1998 .

[40]  B. Chait,et al.  The structure of the potassium channel: molecular basis of K+ conduction and selectivity. , 1998, Science.

[41]  M. Holthaus,et al.  Localization effects in ac-driven tight-binding lattices , 1996, cond-mat/9603015.

[42]  B. Sakmann,et al.  Single-Channel Recording , 1995, Springer US.

[43]  R A Mathies,et al.  Vibrationally coherent photochemistry in the femtosecond primary event of vision. , 1994, Science.

[44]  R A Levis,et al.  Glass technology for patch clamp electrodes. , 1992, Methods in enzymology.

[45]  R A Mathies,et al.  The first step in vision: femtosecond isomerization of rhodopsin. , 1991, Science.

[46]  T Hoshi,et al.  Biophysical and molecular mechanisms of Shaker potassium channel inactivation , 1990, Science.

[47]  Dunlap,et al.  Dynamic localization of a charged particle moving under the influence of an electric field. , 1986, Physical review. B, Condensed matter.

[48]  Christopher Miller,et al.  Ion Channel Reconstitution , 1986, Springer US.

[49]  D. Baylor,et al.  Responses of retinal rods to single photons. , 1979, The Journal of physiology.

[50]  D. Fayuk,et al.  The Journal of Physiology , 1978, Medical History.

[51]  S. Mikhlin,et al.  Variational Methods in Mathematical Physics , 1965 .

[52]  S. Hecht,et al.  ENERGY, QUANTA, AND VISION , 1942, The Journal of general physiology.

[53]  E. Ball,et al.  Proceedings of the NATIONAL ACADEMY OF SCIENCES , 2022 .