Immunoglobulin‐bearing B cells reconstitute and maintain the murine Ly‐1 B cell lineage

Previous reconstitution studies in irradiated mice distinguished Ly‐1 B from other B cells. The predominant B cell populations in spleen and lymph node are readily reconstituted from progenitors present in adult bone marrow. Ly‐1 B cells, in contrast, are reconstituted from cells in peritoneum rather than bone marrow. Further studies, presented here, demonstrate that Ly‐1 B populations are reconstituted from peritoneal cells that already express both surface immunoglobulin (IgM) and Ly‐1, that is, Ly‐1 B. Such cells reconstitute and maintain the Ly‐1 B population in irradiated recipients for at least 6 months.

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